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Isoliquiritigenin attenuates spinal tuberculosis through inhibiting immune response in a New Zealand white rabbit model 원문보기

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.22 no.4, 2018년, pp.369 - 377  

Wang, Wenjing (Record Room, Jinan Second People's Hospital) ,  Yang, Baozhi (Department of Obstetrics & Gynaecology, Jinan Second People's Hospital) ,  Cui, Yong (Department of Traditional Chinese Medicine, Jinan Second People's Hospital) ,  Zhan, Ying (Department of Orthopedics, Shandong Chest Hospital,)

Abstract AI-Helper 아이콘AI-Helper

Spinal tuberculosis (ST) is the tuberculosis caused by Mycobacterium tuberculosis (Mtb) infections in spinal curds. Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is an anti-inflammatory flavonoid derived from licorice (Glycyrrhiza uralensis), a Chinese traditional medicine. In this study, we e...

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  • We therefore hypothesized that ISL might be a potential drug in attenuating the granulomas formation through downregulating the expression of MCP-1 and NF-κB.
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참고문헌 (44)

  1. 1 Garg RK Somvanshi DS Spinal tuberculosis: a review J Spinal Cord Med 2011 34 440 454 22118251 

  2. 2 Kumar K Spinal tuberculosis, natural history of disease, classifications and principles of management with historical perspective Eur J Orthop Surg Traumatol 2016 26 551 558 27435619 

  3. 3 Danaviah S Sacks JA Kumar KP Taylor LM Fallows DA Naicker T Ndung'u T Govender S Kaplan G Immunohistological characterization of spinal TB granulomas from HIV-negative and -positive patients Tuberculosis (Edinb) 2013 93 432 441 23541388 

  4. 4 Taylor GM Murphy E Hopkins R Rutland P Chistov Y First report of Mycobacterium bovis DNA in human remains from the Iron Age Microbiology 2007 153 1243 1249 17379733 

  5. 5 Rajasekaran S Khandelwal G Drug therapy in spinal tuberculosis Eur Spine J 2013 22 Suppl 4 587 593 22581190 

  6. 6 Pawar UM Kundnani V Agashe V Nene A Nene A Multidrug-resistant tuberculosis of the spine?is it the beginning of the end? A study of twenty-five culture proven multidrug-resistant tuberculosis spine patients Spine (Phila Pa 1976) 2009 34 E806 E810 19829244 

  7. 7 Hoshino A Hanada S Yamada H Mii S Takahashi M Mitarai S Yamamoto K Manome Y Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines Pathog Dis 2014 70 28 39 23929604 

  8. 8 World Health Organization Stop TB Initiative Treatment of tuberculosis: guidelines 4th ed Geneva World Health Organization 2010 

  9. 9 Ramakrishnan L Revisiting the role of the granuloma in tuberculosis Nat Rev Immunol 2012 12 352 366 22517424 

  10. 10 Bold TD Ernst JD Who benefits from granulomas, mycobacteria or host? Cell 2009 136 17 19 19135882 

  11. 11 Rubin EJ The granuloma in tuberculosis?friend or foe? N Engl J Med 2009 360 2471 2473 19494225 

  12. 12 Lin PL Flynn JL Understanding latent tuberculosis: a moving target J Immunol 2010 185 15 22 20562268 

  13. 13 Guirado E Schlesinger LS Modeling the Mycobacterium tuberculosis granuloma - the critical battlefield in host immunity and disease Front Immunol 2013 4 98 23626591 

  14. 14 Carr MW Roth SJ Luther E Rose SS Springer TA Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant Proc Natl Acad Sci U S A 1994 91 3652 3656 8170963 

  15. 15 Mecabih F Sadouki F Bennabi M Salah S Boukouaci W Amroun H Fortier C Marzais F Charron D Djoudi H Abbadi MC Krishnamoorthy R Tamouza R Functional polymorphisms of Monocyte Chemoattractant Protein-1 gene and Pott's disease risk Immunobiology 2016 221 462 467 26626202 

  16. 16 Fallahi-Sichani M El-Kebir M Marino S Kirschner DE Linderman JJ Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation J Immunol 2011 186 3472 3483 21321109 

  17. 17 Clay H Volkman HE Ramakrishnan L Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death Immunity 2008 29 283 294 18691913 

  18. 18 Guo XH Bai Z Qiang B Bu FH Zhao N Roles of monocyte chemotactic protein 1 and nuclear factor-κB in immune response to spinal tuberculosis in a New Zealand white rabbit model Braz J Med Biol Res 2017 50 e5625 28225889 

  19. 19 Kwon HM Choi YJ Choi JS Kang SW Bae JY Kang IJ Jun JG Lee SS Lim SS Kang YH Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption Exp Biol Med (Maywood) 2007 232 235 245 17259331 

  20. 20 Kim JY Park SJ Yun KJ Cho YW Park HJ Lee KT Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages Eur J Pharmacol 2008 584 175 184 18295200 

  21. 21 Watanabe Y Nagai Y Honda H Okamoto N Yamamoto S Hamashima T Ishii Y Tanaka M Suganami T Sasahara M Miyake K Takatsu K Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice Sci Rep 2016 6 23097 26975571 

  22. 22 Du F Gesang Q Cao J Qian M Ma L Wu D Yu H Isoliquiritigenin attenuates atherogenesis in apolipoprotein E-deficient mice Int J Mol Sci 2016 17 

  23. 23 Chokchaisiri R Suaisom C Sriphota S Chindaduang A Chuprajob T Suksamrarn A Bioactive flavonoids of the flowers of Butea monosperma Chem Pharm Bull (Tokyo) 2009 57 428 432 19336944 

  24. 24 Brown AK Papaemmanouil A Bhowruth V Bhatt A Dover LG Besra GS Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II Microbiology 2007 153 3314 3322 17906131 

  25. 25 Gaur R Thakur JP Yadav DK Kapkoti DS Verma RK Gupta N Khan F Saikia D Bhakuni RS Erratum to: Synthesis, antitubercular activity, and molecular modeling studies of analogues of isoliquiritigenin and liquiritigenin, bioactive components from Glycyrrhiza glabra Med Chem Res 2015 24 3772 3774 

  26. 26 Barry CE 3rd Boshoff HI Dartois V Dick T Ehrt S Flynn J Schnappinger D Wilkinson RJ Young D The spectrum of latent tuberculosis: rethinking the biology and intervention strategies Nat Rev Microbiol 2009 7 845 855 19855401 

  27. 27 Kim MJ Wainwright HC Locketz M Bekker LG Walther GB Dittrich C Visser A Wang W Hsu FF Wiehart U Tsenova L Kaplan G Russell DG Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism EMBO Mol Med 2010 2 258 274 20597103 

  28. 28 Kobayashi S Miyamoto T Kimura I Kimura M Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro Biol Pharm Bull 1995 18 1382 1386 8593441 

  29. 29 Wang Z Wang N Han S Wang D Mo S Yu L Huang H Tsui K Shen J Chen J Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway PLoS One 2013 8 e68566 23861918 

  30. 30 Jhanji V Liu H Law K Lee VY Huang SF Pang CP Yam GH Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models Br J Ophthalmol 2011 95 1309 1315 21719569 

  31. 31 Lu B Rutledge BJ Gu L Fiorillo J Lukacs NW Kunkel SL North R Gerard C Rollins BJ Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice J Exp Med 1998 187 601 608 9463410 

  32. 32 Flores-Villanueva PO Ruiz-Morales JA Song CH Flores LM Jo EK Montano M Barnes PF Selman M Granados J A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis J Exp Med 2005 202 1649 1658 16352737 

  33. 33 Fallahi-Sichani M Kirschner DE Linderman JJ NF-κB signaling dynamics play a key role in infection control in tuberculosis Front Physiol 2012 3 170 22685435 

  34. 34 Bai X Feldman NE Chmura K Ovrutsky AR Su WL Griffin L Pyeon D McGibney MT Strand MJ Numata M Murakami S Gaido L Honda JR Kinney WH Oberley-Deegan RE Voelker DR Ordway DJ Chan ED Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages PLoS One 2013 8 e61925 23634218 

  35. 35 Liu S Zhu L Zhang J Yu J Cheng X Peng B Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway Biochem Pharmacol 2016 106 82 93 26947453 

  36. 36 Feldman M Santos J Grenier D Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential J Nat Prod 2011 74 1862 1867 21866899 

  37. 37 Wu Y Chen X Ge X Xia H Wang Y Su S Li W Yang T Wei M Zhang H Gou L Li J Jiang X Yang J Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines J Mol Med (Berl) 2016 94 195 206 26383911 

  38. 38 Yan F Yang F Wang R Yao XJ Bai L Zeng X Huang J Wong VKW Lam CWK Zhou H Su X Liu J Li T Liu L Isoliquiritigenin suppresses human T lymphocyte activation via covalently binding cysteine 46 of IκB kinase Oncotarget 2017 8 34223 34235 27626700 

  39. 39 Rook GA Hernandez-Pando R Dheda K Teng Seah G IL-4 in tuberculosis: implications for vaccine design Trends Immunol 2004 25 483 488 15324741 

  40. 40 Moore KW de Waal Malefyt R Coffman RL O'Garra A Interleukin-10 and the interleukin-10 receptor Annu Rev Immunol 2001 19 683 765 11244051 

  41. 41 Zhang M Gong J Iyer DV Jones BE Modlin RL Barnes PF T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection J Clin Invest 1994 94 2435 2442 7989601 

  42. 42 Zhao H Zhang X Chen X Li Y Ke Z Tang T Chai H Guo AM Chen H Yang J Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6 Toxicol Appl Pharmacol 2014 279 311 321 25026504 

  43. 43 Patil T Garg RK Jain A Goel MM Malhotra HS Verma R Singh GP Sharma PK Serum and CSF cytokines and matrix metalloproteinases in spinal tuberculosis Inflamm Res 2015 64 97 106 25503789 

  44. 44 Goyal N Kashyap B Kaur IR Significance of IFN-γ/IL-2 ratio as a circulating diagnostic biomarker in extrapulmonary tuberculosis Scand J Immunol 2016 83 338 344 26946082 

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