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Skin biopsy: an emerging method for small nerve fiber evaluation 원문보기

Annals of clinical neurophysiology : ACN, v.20 no.1, 2018년, pp.3 - 11  

Sohn, Eun Hee (Department of Neurology, Chungnam National University Hospital)

Abstract AI-Helper 아이콘AI-Helper

Skin biopsy and staining the specimens with immuno-reactive markers has been proven to be a useful method to demonstrate the pathologic status of small nerve fibers. Quantification of intraepidermal nerve fiber density using anti-protein gene product 9.5 antibody is a standard method to diagnose sma...

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  • 38 A recent study described phosphorylated α-synuclein deposition which could be a pathophysiological marker of IPD in the skin.39 These studies reporting IPD pathology in the easily accessible skin promote further research about the pathophysiologic mechanism of IPD.
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참고문헌 (40)

  1. Wang L, Hilliges M, Jernberg T, Wiegleb-Edstrom D, Johansson O. Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin. Cell Tissue Res 1990;261:25-33. 

  2. Kennedy WR, Wendelschafer-Crabb G. The innervation of human epidermis. J Neurol Sci 1993;115:184-190. 

  3. McCarthy BG, Hsieh ST, Stocks A, Hauer P, Macko C, Cornblath DR, et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 1995;45:1848-1855. 

  4. Lauria G, Cornblath DR, Johansson O, McArthur JC, Mellgren SI, Nolano M, et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 2005;12:747-758. 

  5. Lauria G, Hsieh ST, Johansson O, Kennedy WR, Leger JM, Mellgren SI, et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol 2010;17:903-912, e44-49. 

  6. Mellgren SI, Nolano M, Sommer C. The cutaneous nerve biopsy: technical aspects, indications, and contribution. Handb Clin Neurol 2013;115:171-188. 

  7. Wang N, Gibbons CH. Skin biopsies in the assessment of the autonomic nervous system. Handb Clin Neurol 2013;117:371-378. 

  8. Braverman IM. The cutaneous microcirculation. J Investig Dermatol Symp Proc 2000;5:3-9. 

  9. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem 2011;59:382-390. 

  10. Pittenger GL, Ray M, Burcus NI, McNulty P, Basta B, Vinik AI. Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care 2004;27:1974-1979. 

  11. Chai J, Herrmann DN, Stanton M, Barbano RL, Logigian EL. Painful small-fiber neuropathy in Sjogren syndrome. Neurology 2005;65:925-927. 

  12. Kennedy WR, Wendelschafer-Crabb G. Utility of skin biopsy in diabetic neuropathy. Semin Neurol 1996;16:163-171. 

  13. Di Leo R, Nolano M, Boman H, Pierangeli G, Provitera V, Knappskog PM, et al. Central and peripheral autonomic failure in cold-induced sweating syndrome type 1. Neurology 2010;75:1567-1569. 

  14. Donadio V, Nolano M, Elam M, Montagna P, Provitera V, Bugiardini E, et al. Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction? Mov Disord 2008;23:885-888. 

  15. Lauria G, Bakkers M, Schmitz C, Lombardi R, Penza P, Devigili G, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst 2010;15:202-207. 

  16. Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 2008;131(Pt 7):1912-1925. 

  17. Nebuchennykh M, Loseth S, Jorde R, Mellgren SI. Idiopathic polyneuropathy and impaired glucose metabolism in a Norwegian patient series. Eur J Neurol 2008;15:810-816. 

  18. Nolano M, Provitera V, Donadio V, Stancanelli A, Saltalamacchia A, Caporaso G, et al. Ross syndrome: a lesson from a monozygotic twin pair. Neurology 2013;80:417-418. 

  19. Nolano M, Provitera V, Perretti A, Stancanelli A, Saltalamacchia AM, Donadio V, et al. Ross syndrome: a rare or a misknown disorder of thermoregulation? A skin innervation study on 12 subjects. Brain 2006;129(Pt 2):2119-2131. 

  20. Smith AG, Ramachandran P, Tripp S, Singleton JR. Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy. Neurology 2001;57:1701-1704. 

  21. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 2003;60:108-111. 

  22. Chao CC, Hsieh ST, Shun CT, Hsieh SC. Skin denervation and cutaneous vasculitis in eosinophilia-associated neuropathy. Arch Neurol 2007;64:959-965. 

  23. Tseng MT, Hsieh SC, Shun CT, Lee KL, Pan CL, Lin WM, et al. Skin denervation and cutaneous vasculitis in systemic lupus erythematosus. Brain 2006;129(Pt 4):977-985. 

  24. Nolano M, Manganelli F, Provitera V, Pisciotta C, Stancanelli A, Caporaso G, et al. Small nerve fiber involvement in CMT1A. Neurology 2015;84:407-414. 

  25. Sghirlanzoni A, Pareyson D, Lauria G. Sensory neuron diseases. Lancet Neurol 2005;4:349-361. 

  26. Nolano M, Provitera V, Caporaso G, Stancanelli A, Vitale DF, Santoro L. Quantification of pilomotor nerves: a new tool to evaluate autonomic involvement in diabetes. Neurology 2010;75:1089-1097. 

  27. Kennedy WR, Wendelschafer-Crabb G, Brelje TC. Innervation and vasculature of human sweat glands: an immunohistochemistry-laser scanning confocal fluorescence microscopy study. J Neurosci 1994;14(11 Pt 2):6825-6833. 

  28. Dabby R, Djaldetti R, Shahmurov M, Treves TA, Gabai B, Melamed E, et al. Skin biopsy for assessment of autonomic denervation in Parkinson's disease. J Neural Transm (Vienna) 2006;113:1169-1176. 

  29. Dabby R, Vaknine H, Gilad R, Djaldetti R, Sadeh M. Evaluation of cutaneous autonomic innervation in idiopathic sensory small-fiber neuropathy. J Peripher Nerv Syst 2007;12:98-101. 

  30. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve 2010;42:112-119. 

  31. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology 2009;72:1479-1486. 

  32. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010;33:2285-2293. 

  33. Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, et al. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 2008;116:277-288. 

  34. Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, et al. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord 2012;27:709-715. 

  35. Pouclet H, Lebouvier T, Coron E, des Varannes SB, Rouaud T, Roy M, et al. A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease. Neurobiol Dis 2012;45:305-309. 

  36. Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008;131(Pt 3):642-650. 

  37. Nolano M, Provitera V, Estraneo A, Selim MM, Caporaso G, Stancanelli A, et al. Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation. Brain 2008;131(Pt 7):1903-1911. 

  38. Wang N, Gibbons CH, Lafo J, Freeman R. ${\alpha}$ -Synuclein in cutaneous autonomic nerves. Neurology 2013;81:1604-1610. 

  39. Schneider SA, Boettner M, Alexoudi A, Zorenkov D, Deuschl G, Wedel T. Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature. Eur J Neurol 2016;23:247-261. 

  40. Shin RK, Galetta SL, Ting TY, Armstrong K, Bird SJ. Ross syndrome plus: beyond horner, Holmes-Adie, and harlequin. Neurology 2000;55:1841-1846. 

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