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NTIS 바로가기Journal of Korean Medicine = 대한한의학회지, v.39 no.1, 2018년, pp.44 - 54
김정완 (대전대학교 한의과대학 경락경혈학교실) , 김재홍 (대전대학교 한의과대학 경락경혈학교실) , 임윤경 (대전대학교 한의과대학 경락경혈학교실)
Objectives: The objective of this study is to investigate the effects of drinking alcohol on bio-electrical potential at twelve source points. Methods: Twenty healthy adults were assigned to alcohol and water groups by a random cross-over design. Bio-electrical potential at twelve source points were...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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음주 시 흡수되는 알코올이 인체의 대사장애에 영향을 주는 이유는? | 음주 시 흡수되는 알코올은 인체에서 주로 위, 대장 및 소장에서 흡수되며 간에서 대사되는데, 일반적으로 microsomal ethanol-oxidizing system (MEOS), alcoholdehydrogenase(ADH) 및 catalase의 3가지 효소계에 의해 아세트알데히드로 분해되고, 또 다시 aldehyde degydrogenase에 의해 아세트산으로 대사되는 과정을 거친다12,20,21). 특히 이 중 대사 중간산물인 아세트알데히드는 오심, 구토와 같은 숙취증상을 유발한다고 알려져 있으며11), 알코올이 대사되는 간의 능력에는 한계가 있기 때문에 이 한계를 넘어설 경우 세포 내 NADH/NAD 비율이 증가하여 단백질, 탄수화물, 지질의 대사장애가 발생하게 된다22). 이 외에도 과량의 음주는 지질단백질의 생성을 가중시켜 일반적으로 알코올을 분해하는 ADH에 의한 대사과정이 아닌 MEOS에 의한 에탄올의 산화를 촉진시키는데, 이러한 대사과정은 지질과산화물을 생성하게 되어 간세포 손상, DNA 변이 등의 병리변화를 유발할 수 있다12). | |
음주의 특징은? | 음주는 일반적으로 알코올성 간염 등 간질환 발생의 위험요인이며, 위염을 유발하고, 대소장 점막을 손상시키며, 스트레스와 감정장애(affective disorder) 등과도 높은 관련이 있다1-10). 특히 음주 시 흡수되는 알코올의 대사 중간산물인 아세트알데히드는 체내에서 오심, 구토와 같은 숙취증상을 유발하며, 한 번에 과량의 술을 복용하면 지질단백질의 생성을 가중시켜 간세포 손상이나 DNA 변이, 위점막 손상 등을 유발하게 된다11,12). | |
음주 시 흡수되는 알코올의 대사 중간산물은 인체에 어떠한 영향을 끼치는가? | 음주는 일반적으로 알코올성 간염 등 간질환 발생의 위험요인이며, 위염을 유발하고, 대소장 점막을 손상시키며, 스트레스와 감정장애(affective disorder) 등과도 높은 관련이 있다1-10). 특히 음주 시 흡수되는 알코올의 대사 중간산물인 아세트알데히드는 체내에서 오심, 구토와 같은 숙취증상을 유발하며, 한 번에 과량의 술을 복용하면 지질단백질의 생성을 가중시켜 간세포 손상이나 DNA 변이, 위점막 손상 등을 유발하게 된다11,12). |
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