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세라미스트 = Ceramist, v.21 no.3, 2018년, pp.249 - 269
박종민 (연세대학교 신소재공학과) , 노주윤 (연세대학교 신소재공학과) , 김문주 (연세대학교 신소재공학과) , 변재철 (연세대학교 신소재공학과)
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In conventional MALDI-TOF mass spectrometry, analyte molecules are known to be ionized by mixing with organic matrix molecules. As the organic matrix molecules are made into small fragments, they generate unreproducible mass peaks such that MALDI-TOF mass spectrometry is nearly impossible in the low...
| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 질량분석을 위해 요구되는 과정은? | 분자량은 물질의 특성이므로 분자량의 측정을 통해 대상물의 동정(identification)이 가능하며, 많은 경우 정량(quantification)이 가능한 기술이다. 질량분석을 위해서는 시료를 이온화하는 과정과 이온화된 시료를 질량에 따라 분리하는 과정이 필요하다. 시료의 이온화 과정은 이온화를 위한 소스종류에 따라 분류된다. | |
| 질량분석기술이란 무엇인가? | 질량분석기술은 분석대상물의 분자량을 측정하는 기술이다. 분자량은 물질의 특성이므로 분자량의 측정을 통해 대상물의 동정(identification)이 가능하며, 많은 경우 정량(quantification)이 가능한 기술이다. | |
| 말디톱 질량분석법이 분자량을 산출하는 방법은 무엇인가? | 즉, 분자량이 큰 무거운 분자는 상대적으로 작고 가벼운 분자에 비해 탐지기에 도달하는데 상대적으로 긴 시간이 걸리게 된다. 따라서, 탐지기에 도달하기 위해 걸리는 비행시간을 측정하여 분자량을 산출하게 된다. 이와 같이 측정된 분자량을 통해 시료분자의 동정이 가능하며, 탐지기에 도달한 이온량에 따라 질량분석 피트의 크기가 결정 되므로 이온량의 정량이 가능하다(Fig. |
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