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Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway 원문보기

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.23 no.2, 2019년, pp.103 - 111  

Zhang, Qi (Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Anhui Institute of Cardiovascular Disease) ,  Hu, Li-qun (Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Anhui Institute of Cardiovascular Disease) ,  Li, Hong-qi (Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Anhui Institute of Cardiovascular Disease) ,  Wu, Jun (Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Anhui Institute of Cardiovascular Disease) ,  Bian, Na-na (Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Anhui Institute of Cardiovascular Disease) ,  Yan, Guang (Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Tec)

Abstract AI-Helper 아이콘AI-Helper

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-speci...

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  • In this study, we investigated the effects of andrographolide in a rat model of EAM. Treatment with andrographolide reduced mortality rates, improved cardiomyopathology and cardiac functions.
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