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NTIS 바로가기대한영양사협회 학술지 = Journal of the Korean dietetic association, v.25 no.2, 2019년, pp.83 - 104
박지연 (서울여자대학교 자연과학대학 식품영양학과) , 김미정 (서울여자대학교 자연과학대학 식품영양학과) , 김정희 (서울여자대학교 자연과학대학 식품영양학과)
Elevated high-sensitivity C reactive protein (hs-CRP) levels and metabolic syndrome are considered important predictors of cardiovascular mortality. This study examined the influence of the alcohol consumption level on the hs-CRP level and the prevalence of metabolic syndrome in South Koreans. The s...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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위장점막의 알코올탈수소효소에 의해 1차적으로 분해한 후 남은 알코올은 간에서 어떻게 되는가? | 알코올은 위장과 소장에서 흡수되어 간에서 대사되며, 일부는 흡수 전에 위장점막의 알코올탈수소효소에 의해 1차적으로 분해된다. 나머지는 간에 도달한 후 알코올탈수소효소에 의해 아세트알데하이드(acetaldehyde)로 산화되고 알데히드탈수소효소에 의해 아세트산(acetic acid)으로 산화된다. 이러한 과정에서 NAD(nicotinamid adenine dinucleotide)의 공급이 필요하기 때문에 장기간의 알코올 섭취 시 세포의 전체적인 산화-환원에 영향을 미친다. | |
hs-CRP 측정법의 개발로 무엇이 가능해졌는가? | C-reactive protein(CRP)은 감염 및 염증 상태에서 증가하는 대표적인 급성기 단백질로 interlukin-6 (IL-6)과 같은 염증성 사이토카인(cytokine)의 자극에 의해 주로 간에서 합성된다(Ridker 등 2001; Ablij & Meinders 2002). 기술의 발달로 hs-CRP 측정법이 개발되어 낮은 농도에서도 높은 정밀도로 CRP 측정이 가능해졌고, 만성염증에 의한 경도의 CRP 상승도 측정이 가능해졌다. 최근 동맥경화증의 발생 및 진행에 만성적인 염증반응이 관여하는 것으로 밝혀지면서(Libby 등 2002) hs-CRP는 건강한 성인에서 관상동맥질환의 위험도를 예측할 수 있는 인자로 주목받고 있다. | |
C-reactive protein(CRP)은 무엇인가? | C-reactive protein(CRP)은 감염 및 염증 상태에서 증가하는 대표적인 급성기 단백질로 interlukin-6 (IL-6)과 같은 염증성 사이토카인(cytokine)의 자극에 의해 주로 간에서 합성된다(Ridker 등 2001; Ablij & Meinders 2002). 기술의 발달로 hs-CRP 측정법이 개발되어 낮은 농도에서도 높은 정밀도로 CRP 측정이 가능해졌고, 만성염증에 의한 경도의 CRP 상승도 측정이 가능해졌다. |
Ablij H, Meinders A (2002): C-reactive protein: history and revival. Eur J Intern Med 13(7):412
Alatalo PI, Koivisto HM, Hietala JP, Puukka KS, Bloigu R, Niemela OJ (2008): Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index. Am J Clin Nutr 88(4):1097-1103
Albert MA, Glynn RJ, Ridker PM (2003): Alcohol consumption and plasma concentration of C-reactive protein. Circulation 107(3):443-447
Averina M, Nilssen O, Arkhipovsky VL, Kalinin AG, Brox J (2006): C-reactive protein and alcohol consumption: is there a U-shaped association? Results from a population-based study in Russia. The Arkhangelsk study. Atherosclerosis 188(2):309-315
Bagnardi V, Blangiardo M, La Vecchia C, Corrao G (2001): A meta-analysis of alcohol drinking and cancer risk. Br J Cancer 85(11):1700-1705
Baik I, Shin C (2008): Prospective study of alcohol consumption and metabolic syndrome. Am J Clin Nutr 87(5):1455-1463
Baliunas DO, Taylor BJ, Irving H, Roerecke M, Patra J, Mohapatra S, Rehm J (2009): Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 32(11):2123-2132
Beaglehole R, Jackson R (1992): Alcohol, cardiovascular diseases and all causes of death: a review of the epidemiological evidence. Drug Alcohol Rev 11(3):275-289
Briasoulis A, Agarwal V, Messerli FH (2012): Alcohol consumption and the risk of hypertension in men and women: a systematic review and meta-analysis. J Clin Hypertens (Greenwich) 14(11):792-798
Chae HB (2009): Alcoholic liver disease. Korean J Gastroenterol 53(5):275-282
Cho YG, Kang JH (2006): C-reactive protein and prevention of cardiovascular disease. Korean J Obes 15(2):81-90
Choudhury SR, Ueshima H, Kita Y, Kobayashi KM, Okayama A, Yamakawa M, Hirao Y, Ishikawa M, Miyoshi Y (1994): Alcohol intake and serum lipids in a Japanese population. Int J Epidemiol 23(5):940-947
Davies MJ, Baer DJ, Judd JT, Brown ED, Campbell WS, Taylor PR (2002): Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA 287(19):2559-2562
Fan AZ, Russell M, Dorn J, Freudenheim JL, Nochajski T, Hovey K, Trevisan M (2006): Lifetime alcohol drinking pattern is related to the prevalence of metabolic syndrome. The Western New York Health Study (WNYHS). Eur J Epidemiol 21(2):129-138
Ford ES (2005): Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 28(7):1769-1778
Frohlich M, Imhof A, Berg G, Hutchinson WL, Pepys MB, Boeing H, Muche R, Brenner H, Koenig W (2000): Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Diabetes Care 23(12):1835-1839
Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, Willett W, Hennekens CH (1993): Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med 329(25):1829-1834
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005): Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112(17):2735-2752
Hannuksela M, Marcel YL, Kesaniemi YA, Savolainen MJ (1992): Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol. J Lipid Res 33(5):737-744
Holbrook TL, Barrett-Connor E, Wingard DL (1990): A prospective population-based study of alcohol use and non-insulin-dependent diabetes mellitus. Am J Epidemiol 132(5):902-909
Imhof A, Froehlich M, Brenner H, Boeing H, Pepys MB, Koenig W (2001): Effect of alcohol consumption on systemic markers of inflammation. Lancet 357(9258):763-767
Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L (2001): Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24(4):683-689
Jang JE, Koh EH (2012): The impacts of alcohol consumption on glucose metabolism. J Korean Diabetes 13(2):81-84
Kang HT, Kim SY, Kim JS, Kim JW, Kim JY, Park HA, Shin JY, Cho SH, Choi YG, Shim JY (2015): Clinical practice guideline of prevention and treatment for metabolic syndrome. Korean J Fam Pract 5(3):375-420
Kao WH, Puddey IB, Boland LL, Watson RL, Brancati FL (2001): Alcohol consumption and the risk of type 2 diabetes mellitus: atherosclerosis risk in communities study. Am J Epidemiol 154(8):748-757
Kim JS(2018). Thirteen people death everyday due to alcohol abuse. Heavy drinkers are 30.5% of Koreans, who are the most all over the world. Available from: http://news.mt.co.kr/mtview.php?no2018111312481571456. Accessed January 23, 2019
Kim KJ, Jung H, Park KT, Kim MT, Oh TK, Lee SH, Kim HW (2015): Relation between healthy drinking habits and metabolic syndrome. Korean J Fam Pract 5(3):361-367
Klatsky AL (2007): Alcohol, cardiovascular diseases and diabetes mellitus. Pharmacol Res 55(3):237-247
Klop B, do Rego AT, Cabezas MC (2013): Alcohol and plasma triglycerides. Curr Opin Lipidol 24(4):321-326
Kweon GY (2005): Factors influencing drinking of employees: focus on the white collar employees. Korean J Soc Welf 57(2):93-118
Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT (2002): The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288(21):2709-2716
Libby P, Ridker PM, Maseri A (2002): Inflammation and atherosclerosis. Circulation 105(9):1135-1143
Lim S, Shin H, Song JH, Kwak SH, Kang SM, Won Yoon J, Choi SH, Cho SI, Park KS, Lee HK, Jang HC, Koh KK (2011): Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007. Diabetes Care 34(6):1323-1328
Linn S, Carroll M, Johnson C, Fulwood R, Kalsbeek W, Briefel R (1993): High-density lipoprotein cholesterol and alcohol consumption in US white and black adults: data from NHANES II. Am J Public Health 83(6):811-816
Mayer EJ, Newman B, Quesenberry CP Jr, Friedman GD, Selby JV (1993): Alcohol consumption and insulin concentrations. Role of insulin in associations of alcohol intake with high-density lipoprotein cholesterol and triglycerides. Circulation 88(5 Pt 1):2190-2197
Murphy A, Roberts B, Stickley A, McKee M (2012): Social factors associated with alcohol consumption in the former Soviet Union: a systematic review. Alcohol Alcohol 47(6):711-718
Nakanishi N, Makino K, Nishina K, Suzuki K, Tatara K (2002): Relationship of light to moderate alcohol consumption and risk of hypertension in Japanese male office workers. Alcohol Clin Exp Res 26(7):988-994
Oliveira A, Rodriguez-Artalejo F, Lopes C (2010): Alcohol intake and systemic markers of inflammation--shape of the association according to sex and body mass index. Alcohol Alcohol 45(2):119-125
Orchard TJ, Temprosa M, Goldberg R, Haffner S, Ratner R, Marcovina S, Fowler S (2005): The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med 142(8):611-619
Park SH, Kang YH, Park HY (2008): Alcohol consumption and the coronary heart disease-related risk factors in Korean adults: the third Korea National Health and Nutrition Examination Survey (KNHANES III), 2005. J Nutr Health 41(3):232-241
Ridker PM, Stampfer MJ, Rifai N (2001): Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 285(19):2481-2485
Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ (1999): Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 319(7224):1523-1528
Sesso HD, Cook NR, Buring JE, Manson JE, Gaziano JM (2008): Alcohol consumption and the risk of hypertension in women and men. Hypertension 51(4):1080-1087
Sierksma A, van der Gaag MS, Kluft C, Hendriks HF (2002): Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. Eur J Clin Nutr 56(11):1130-1136
Suter PM (2005): Is alcohol consumption a risk factor for weight gain and obesity?. Crit Rev Clin Lab Sci 42(3):197-227
Traversy G, Chaput JP (2015): Alcohol consumption and obesity: an update. Curr Obes Rep 4(1):122-130
Wakabayashi I (2010): Cross-sectional relationship between alcohol consumption and prevalence of metabolic syndrome in Japanese men and women. J Atheroscler Thromb 17(7):695-704
Wang L, Lee IM, Manson JE, Buring JE, Sesso HD (2010):Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women. Arch Intern Med 170(5):453-461
Witteman JC, Willett WC, Stampfer MJ, Colditz GA, Kok FJ, Sacks FM, Speizer FE, Rosner B, Hennekens CH (1990): Relation of moderate alcohol consumption and risk of systemic hypertension in women. Am J Cardiol 65(9):633-637
World Health Organization (2014). Global status report on alcohol and health 2014. Available from: http://apps.who.int/iris/bitstream/10665/112736/1/9789240692763_eng.pdf. Accessed January 4, 2018
Yoon YS, Oh SW, Baik HW, Park HS, Kim WY (2004): Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey. Am J Clin Nutr 80(1):217-224
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