$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Korean Red Ginseng increases defective pol gene in peripheral blood mononuclear cells of HIV-1-infected patients; inhibition of its detection during ginseng-based combination therapy

Journal of ginseng research = 高麗人參學會誌, v.43 no.4, 2019년, pp.684 - 691  

Cho, Young Keol (Department of Microbiology, University of Ulsan College of Medicine) ,  Kim, Jung-Eun (Department of Microbiology, University of Ulsan College of Medicine) ,  Woo, Jun-Hee (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)

Abstract AI-Helper 아이콘AI-Helper

Background: We have reported that defective nef and gag genes are induced in HIV-1-infected patients treated with Korean Red Ginseng (KRG). Methods: To investigate whether KRG treatment and highly active antiretroviral therapy (HAART) affect genetic defects in the pol gene, we amplified and sequence...

주제어

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

문제 정의

  • To my knowledge, this report is the first documented study on the gross deletion or ID in the pol gene level by a specific treatment. Recently, a significant proportion of the resulting proviruses have revealed large deletions when recombination was blocked [52].

가설 설정

  • In this study, we first confirmed that KRG causes defects in the pol gene, although it is the most conserved gene of HIV-1 and that the defect rate is significantly affected by the size of the PCR amplicon (about 1.2 kb versus 3.0 kb). This study is the first one which has obtained a high defective gene rate of 11.
본문요약 정보가 도움이 되었나요?

참고문헌 (54)

  1. J Virol Li 65 3973 1991 10.1128/JVI.65.8.3973-3985.1991 Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes 

  2. J Virol Sanchez 71 2233 1997 10.1128/JVI.71.3.2233-2240.1997 Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals 

  3. AIDS Res Hum Retroviruses Trabaud 31 142 2015 10.1089/aid.2014.0129 Persistent production of an integrase-deleted HIV-1 variant with no resistance mutation and wild-type proviral DNA in a treated patient 

  4. Cell Ho 155 540 2013 10.1016/j.cell.2013.09.020 Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure 

  5. Nat Med Bruner 22 1043 2016 10.1038/nm.4156 Defective proviruses rapidly accumulate during acute HIV-1 infection 

  6. Cell Rep Hiener 21 813 2017 10.1016/j.celrep.2017.09.081 Identification of genetically intact HIV-1 proviruses in specific CD4+ T cells from effectively treated participants 

  7. Science Coffin 267 483 1995 10.1126/science.7824947 HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy 

  8. Virology Huang 240 36 1998 10.1006/viro.1997.8913 Characterization of gag and pol sequences from long-term survivors of human immunodeficiency virus type 1 infection 

  9. Virology Zhang 228 340 1997 10.1006/viro.1996.8378 Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection 

  10. J Virol Miura 82 8422 2008 10.1128/JVI.00535-08 Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of internal genetic defects or common amino acid changes 

  11. Science Deacon 270 988 1995 10.1126/science.270.5238.988 Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients 

  12. J Virol Churchill 80 1047 2006 10.1128/JVI.80.2.1047-1052.2006 Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source 

  13. Immunity Deeks 27 406 2007 10.1016/j.immuni.2007.08.010 Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy 

  14. Am J Chin Med (Gard City N Y) Li 1 249 1973 10.1142/S0192415X73000279 An introductory note to ginseng 

  15. Vaccine Sakure 26 3387 2008 10.1016/j.vaccine.2008.01.060 Vaccine with herbal adjuvant-a better cocktail to combat the infection 

  16. Vaccine Rivera 23 5411 2005 10.1016/j.vaccine.2005.04.007 The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response 

  17. J Ginseng Res Im 40 4 309 2016 10.1016/j.jgr.2015.09.002 Ginseng, the natural effectual antiviral: protective effects of Korean Red Ginseng against viral infection 

  18. J Korean Soc Microbiol Cho 29 371 1994 The increase of T cell by Korean red ginseng in HIV-infected individuals 

  19. J Korean Soc Microbiol Cho 31 353 1996 The effect of Korean red ginseng (KRG), zidovudine (ZDV), and the combination of KRG and ZDV on HIV-infected patients 

  20. J Korean Soc Microbiol Cho 32 611 1997 Sequence analysis of C2-V3 region of human immunodeficiency virus type 1 gp120 and its correlation with clinical significance: the effect of long-term treatment of Korean red ginseng on env gene variation 

  21. J Ginseng Res Cho 31 175 2007 10.5142/JGR.2007.31.4.175 Effect of Korean red ginseng on serum soluble CD8 in HIV-1- infected patients 

  22. Curr HIV Res Cho 4 447 2006 10.2174/157016206778560072 High proportion of grossly deleted nef genes in HIV-1 infected long-term slow progressors treated with Korean red ginseng 

  23. AIDS Res Hum Retroviruses Cho 25 419 2009 10.1089/aid.2008.0178 Frequent gross deletion in the HIV type 1 nef gene in hemophiliacs treated with Korean Red Ginseng: inhibition of detection by highly active antiretroviral therapy 

  24. J Ginseng Res Cho 41 144 2017 10.1016/j.jgr.2016.02.005 Genetic defects in the nef gene are associated with Korean Red Ginseng treatment: monitoring of nef sequence polymorphisms over 20 years 

  25. N Engl J Med Palella 338 853 1998 10.1056/NEJM199803263381301 Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators 

  26. Int Immunopharmacol Cho 1 1295 2001 10.1016/S1567-5769(01)00061-3 Long-term treatment of Korean red ginseng in HIV-1-infected patients: development of resistance mutation to zidovudine is delayed 

  27. J Ginseng Res Cho 28 173 2004 10.5142/JGR.2004.28.4.173 Korean red ginseng significantly slows CD4 T cell depletion over 10 years in HIV-1 infected patients: association with HLA 

  28. Clin Diagn Lab Immunol Sung 12 497 2005 10.1128/CDLI.12.4.497-501.2005 Korean red ginseng slows depletion of CD4 T cells in human immunodeficiency virus type 1-infected patients 

  29. AIDS Res Hum Retroviruses Cho 24 181 2008 10.1089/aid.2007.0143 High proportion of gross deletions in the 5' LTR and gag regions in HIV type 1-infected long-term survivors treated with Korean Red Ginseng 

  30. AIDS Res Hum Retroviruses Cho 25 535 2009 10.1089/aid.2008.0301 High proportion of gross deletions in 5' LTR/gag and nef genes in patients infected with CRF02_AG of HIV type 1 who survived for over 20 years: an association with Korean red ginseng 

  31. J Ginseng Res Cho 34 219 2010 10.5142/jgr.2010.34.3.219 Dosage and duration effects of KRG treatment on proportion of gross deletions in the nef gene 

  32. J Ginseng Res Cho 35 413 2011 10.5142/jgr.2011.35.4.413 Frequent genetic defects in the HIV-1 5’LTR/gag gene in hemophiliacs treated with Korean red ginseng; decreased detection of genetic defects by highly active antiretroviral therapy 

  33. Virology Sandonís 391 73 2009 10.1016/j.virol.2009.05.022 A combination of defective DNA and protective host factors are found in a set of HIV-1 ancestral LTNPs 

  34. Curr HIV Res Paolucci 9 17 2011 10.2174/157016211794582641 Accumulation of defective HIV-1 variants in a patient with slow disease progression 

  35. Clin Vaccine Immunol Sung 16 1127 2009 10.1128/CVI.00013-09 Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients 

  36. AIDS Res Hum Retroviruses Cho 27 613 2011 10.1089/aid.2010.0174 Phylogenetic analysis of full-length pol gene from Korean hemophiliacs and plasma donors infected with Korean subclade B of HIV-1 

  37. Nature Ho 373 123 1995 10.1038/373123a0 Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection 

  38. Nature Wei 373 117 1995 10.1038/373117a0 Viral dynamics in human immunodeficiency virus type 1 infection 

  39. Proc Natl Acad Sci USA Imamichi 113 8783 2016 10.1073/pnas.1609057113 Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy 

  40. BioTechniques Sanchez 24 400 1998 10.2144/98243bm14 Relative amplification efficiency of differently sized templates by long-distance PCR 

  41. Biochem Pharmacol Attele 58 1685 1999 10.1016/S0006-2952(99)00212-9 Ginseng pharmacology: multiple constituents and multiple actions 

  42. Phytotherapy Res Simões 13 323 1999 10.1002/(SICI)1099-1573(199906)13:4<323::AID-PTR448>3.0.CO;2-C Mechanisms of antiviral activity of triterpenoid saponins 

  43. Phytochem Lett Wei 2 63 2009 10.1016/j.phytol.2008.12.001 Anti-HIV protease triterpenoids from the acid hydrolysate of Panax ginseng 

  44. Tetrahedron Lett Zhang 43 973 2002 10.1016/S0040-4039(01)02310-3 Polyacetylenginseng-Ro, a novel triterpene saponin from Panax ginseng 

  45. Life Sci Lam 70 3049 2002 10.1016/S0024-3205(02)01557-6 A xylanase from roots of sanchi ginseng (Panax notoginseng) with inhibitory effects on human immunodeficiency virus-1 reverse transcriptase 

  46. Immunopharmacology See 35 229 1997 10.1016/S0162-3109(96)00125-7 In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients 

  47. Eur J Immunol Ahn 36 37 2006 10.1002/eji.200535138 The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals 

  48. J Interferon Cytokine Res Nakaya 24 93 2004 10.1089/107999004322813336 Panax ginseng induces production of proinflammatory cytokines via toll-like receptor 

  49. Planta Med Kim 64 110 1998 10.1055/s-2006-957385 Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2 

  50. APMIS Larsen 112 369 2004 10.1111/j.1600-0463.2004.apm1120607.x Ginseng modulates the immune response by induction of interleukin-12 production 

  51. J Ginseng Res Yang 32 315 2008 10.5142/JGR.2008.32.4.315 Compound K rich fractions regulate NF-κB-dependent inflammatory responses and protect mice from endotoxin-induced lethal shock 

  52. Nucleic Acids Res Rawson 16 10535 2018 Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity 

  53. J Virol Chaillon 92 2018 10.1128/JVI.01589-17 Size, composition, and evolution of HIV DNA populations during early antiretroviral therapy and intensification with maraviroc 

  54. Acta Trop Mutabingwa 95 305 2005 10.1016/j.actatropica.2005.06.009 Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy! 

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트