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NTIS 바로가기韓國家畜衛生學會誌 = Korean journal of veterinary service, v.43 no.2, 2020년, pp.89 - 97
문자영 (전북대학교 수의과대학) , (전북대학교 수의과대학) , 김원경 (전북대학교 수의과대학) , 이준우 (전북대학교 수의과대학) , 조영규 (전북대학교 수의과대학) , 곽길한 (전라북도가축위생시험소) , 박병용 (전북대학교 수의과대학) , 허진 (전북대학교 수의과대학)
This study was carried out to examine a novel inactivated Salmonella Typhimurium (S. Typhimurium) vaccine candidate for protection of mice against salmonellosis by immunization of BALB/c mice using various type adjuvant. The novel type-inactivated vaccine candidate was constructed by adding Chlorhex...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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살모넬라증은 가축에게 어떤 피해를 입히는가? | 이 질병은 건강한 성인의 경우 2, 3일안에 회복되지만 어린이, 노인 및 면역력이 저하된 환자들은 급성 살모넬라증으로 사망의 주요 원인이 될 수 있다(Fàbrega와 Vila, 2013). 또한 돼지 및 닭 등 가축에서의 살모넬라증은 어린 새끼 때 주로 발생하며 패혈증과 설사, 발열, 황달 등 전신증상을 일으키며 사료 효율의 저하와 높은 폐사율 등 사육 농가에 심각한 경제적 피해를 입히고 있는 것으로 알려져 있다(Schwartz 등, 1999; Kim 등, 2014). 또한 회복 후에도 보균 가축으로 장기간 균을 배출하여 주변 가축 및 환경을 오염시키는 것으로 보고 되고 있다 (Schwartz 등, 1999). | |
Water in Oil (W/O) 정제된 용액이 효과적이지 않은 경우는 어떨 때인가? | 국내 농장에서 많이 사용하는 백신의 adjuvant는 ISA70으로 Water in Oil (W/O) 정제된 mannitol/oleic acid 유화제를 합한 미네랄 오일기반 용액으로 가금류, 소 및 반추동물의 병원체에 대한 면역반응을 높이고 안전성 또한 효과적인 것으로 밝혀져 많이 사용되고 있다(Dupuis 등, 2006). 그러나 W/O adjuvant를 사용할 경우 백신 제형이 오일이기 때문에 점막 면역이 중요한 백신에서는 효과적이지 않다, 그러나 IMS1313 은 Oil in Water (O/W)로 면역 자극 성분을 함유하고 상용성인 수성상 액체 나노 입자 분산액으로 점막 전달에 용이 하고 대량 백신 접종을 위해 사용될 수도 있다(Jang 등, 2011; Ismail 등, 2018). | |
Salmonella enterica serovor Typhimurium (S. Typhimurium)란 무엇인가? | Salmonella enterica serovor Typhimurium (S. Typhimurium)은 세포 내에 기생하는 병원성 그람 음성 세균이며 식품 매개 질병의 가장 흔한 원인체 중 하나로 사람에서 식중독을 일으키는 주요 원인균이다(Norimatsu 등, 2004; Fàbrega와 Vila, 2013). 이 질병은 건강한 성인의 경우 2, 3일안에 회복되지만 어린이, 노인 및 면역력이 저하된 환자들은 급성 살모넬라증으로 사망의 주요 원인이 될 수 있다(Fàbrega와 Vila, 2013). |
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