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NTIS 바로가기대한한방내과학회지 = The journal of internal Korean medicine, v.41 no.3, 2020년, pp.306 - 325
김윤정 (동의대학교 부속한방병원 한방내과학) , 정유진 (동의대학교 부속한방병원 한방내과학) , 박동일 (동의대학교 부속한방병원 한방내과학)
Objectives: The aim of this study is to investigate the effect of a Dachaihu decoction for hyperlipidemic acute pancreatitis (HLAP) by systematic review and meta-analysis of Chinese clinical studies. Methods: China National Knowledge Infrastructure (CNKI) was utilized as the major search engine. The...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
고지혈성 급성 췌장염이란? | 고지혈성 급성 췌장염은 고지혈증이 원인이 되어 발생하는 췌장의 급성 염증성 질환이다1 . 급성 췌장염은 알코올과 담석이 주요 요인으로 작용하지만, 생활 방식의 서구화(지방 섭취 과다, 과식 및 운동부족)로 인하여 고지혈증이 세 번째 주요 원인이 되고 있다2 . | |
급성 췌장염의 주요 요인들로는 무엇들이 있는가? | 고지혈성 급성 췌장염은 고지혈증이 원인이 되어 발생하는 췌장의 급성 염증성 질환이다1 . 급성 췌장염은 알코올과 담석이 주요 요인으로 작용하지만, 생활 방식의 서구화(지방 섭취 과다, 과식 및 운동부족)로 인하여 고지혈증이 세 번째 주요 원인이 되고 있다2 . 고지혈성 급성 췌장염은 급성 췌장염의 10% 이상을 차지한다3 . | |
고지혈성 급성 췌장염의 기전은 어떻게 보고있는가? | 고지혈성 급성췌장 염의 병태생리학적 기전은 아직 정확하게 밝혀지지 않았다. 중성지방(Triglyceride, TG)의 대사산물인 고농도의 유리 지방산(Free fatty acid, FFA)이 췌장의 선포세포와 혈관 내피의 손상을 유발하여 비활성화된 전구체 형태로 존재해야 하는 췌장 합성 소화효소를 췌장 내에서 활성화시키거나 TG의 분해 증가로 생성된 고농도의 카일로마이크론(Chylomicron) 이 모세혈관의 폐색을 일으켜, 췌장에 염증이 발생하고 췌장 조직 허혈성 괴사가 발생할 것이라고 보고 있다4. |
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