$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Potential role of environmental genotoxic agents in diabetes mellitus and neurodegenerative diseases

Biochemical pharmacology, v.51 no.12, 1996년, pp.1585 - 1591  

Abstract AI-Helper 아이콘AI-Helper

AbstractEpidemiological data suggest that environmental genotoxins are risk factors for some forms of diabetes mellitus and neurodegenerative diseases. The present commentary focuses on mechanisms involved in genotoxin-induced pancreatic β-cell and neuronal damage. These two cell types seem to ...

주제어

참고문헌 (92)

  1. Hellerström 53 1985 Diabetes Pancreas Growth pattern of pancreatic islets in mammals 

  2. J Neurol Sci Mazzarello 112 4 1992 10.1016/0022-510X(92)90125-5 DNA repair mechanisms in neurological diseases: Facts and hypothesis 

  3. Diabetes Scharfmann 42 1829 1993 10.2337/diab.42.12.1829 Expression of functional nerve growth factor receptors in pancreatic β-cell lines and fetal rat islets in primary culture 

  4. Annu Rev Physiol De Camilli 52 625 1990 10.1146/annurev.ph.52.030190.003205 Pathways to regulated exocytosis in neurons 

  5. News Physiol Sci Rorsman 5 143 1990 ATP-regulated K+ channels and diabetes mellitus 

  6. Diabetes Sorenson 40 1365 1991 10.2337/diab.40.11.1365 Structure and functional considerations of GABA in islets of Langerhans, β-cells and nerves 

  7. Dev Biol Teitelman 142 368 1990 10.1016/0012-1606(90)90357-O Insulin cells of the pancreas extend neurites but do not arise from the neuroectoderm 

  8. Annu Rev Biochem Wallace 61 1175 1992 10.1146/annurev.bi.61.070192.005523 Diseases of the mitochondrial DNA 

  9. Diabetologia Gerbitz 35 1181 1992 10.1007/BF00401375 Does the mitochondrial DNA play a role in the pathogenesis of diabetes? 

  10. Diabetes Koerner 25 1055 1976 10.2337/diab.25.11.1055 Abnormal carbohydrate metabolism in amyotrophic lateral sclerosis and Parkinsonism-dementia on Guam 

  11. Chen 199 1984 Amyotrophic Lateral Sclerosis in Asia and Oceania Amyotrophic lateral sclerosis and Parkinson-dementia in Guam: An update 

  12. Can J Neurol Sci Spencer 14 347 1987 10.1017/S0317167100037732 Guam ALS/Parkinson-dementia: A long-latency neurotoxic disorder caused by “slow toxin(s)” in food? 

  13. Mutat Res Tricker 259 277 1991 10.1016/0165-1218(91)90123-4 Carcinogenic N-nitrosamines in the diet: Occurrence, formation, mechanisms and carcinogenic potential 

  14. Neurology Spencer 41 Suppl 2 62 1991 10.1212/WNL.41.5_Suppl_2.62 Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region 

  15. Diabetes Rev Rossini 1 43 1993 Immunopathogenesis of diabetes mellitus 

  16. Diabetes Metab Rev Dahlquist 11 37 1995 10.1002/dmr.5610110104 Environmental risk factors in human type 1 diabetes-An epidemiological perspective 

  17. Diabete Metab Dahlquist 20 251 1994 Non-genetic risk determinants of type 1 diabetes 

  18. Diabetes Metab Rev Yoon 11 83 1995 10.1002/dmr.5610110202 A new look at viruses in type 1 diabetes 

  19. Lancet Helgason II 716 1981 10.1016/S0140-6736(81)91048-5 Evidence for food additive as a cause of ketosis-prone diabetes 

  20. Lancet Helgason II 1017 1982 10.1016/S0140-6736(82)90052-6 Diabetes produced in mice by smoked/cured mutton 

  21. Br Med J Dahlquist 300 1302 1990 10.1136/bmj.300.6735.1302 Dietary factors and the risk of developing insulin-dependent diabetes mellitus in childhood 

  22. Diabetes Care Kostraba 15 1505 1992 10.2337/diacare.15.11.1505 Nitrate levels in community drinking waters and risk of IDDM 

  23. Diabetologia Boucher 37 49 1994 10.1007/BF00428777 Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CDI mice and in their F1 and F2 offspring 

  24. Biochem Pharmacol Eizirik 50 355 1995 10.1016/0006-2952(95)00150-X Cycad toxin-induced damage of rodent and human pancreatic β-cells 

  25. Curr Top Microbiol Immunol Wilson 156 27 1990 Streptozotocin interactions with pancreatic β-cells and the induction of diabetes 

  26. Wilson 17 1993 Lessons from Animal Diabetes IV Interactions of chemicals with pancreatic β-cells 

  27. Science Like 193 415 1976 10.1126/science.180605 Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus 

  28. Diabetes Rev Kolb 1 116 1993 IDDM-Lessons from the low-dose Streptozotocin model in mice 

  29. Brain Res Mayer 532 95 1990 10.1016/0006-8993(90)91747-5 Effects of changes to peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats 

  30. Int J Dev Neurosci Plaschke 11 477 1993 10.1016/0736-5748(93)90021-5 Action of the diabetogenic drug Streptozotocin on glycolytic and glycogenolytic metabolism of adult brain cortex and hippocampus 

  31. J Cereb Blood Flow Metab Ding 12 103 1992 10.1038/jcbfm.1992.13 Changes in brain monoaminergic neurotransmitter concentrations in rat after intracerebroventricular injection of Streptozotocin 

  32. J Neurosci Res Hellweg 31 479 1992 10.1002/jnr.490310310 Nerve growth factor and choline acetyltransferase activity levels in the rat brain following experimental impairment of cerebral glucose and energy metabolism 

  33. Pharmacol Biochem Behav Blokland 47 833 1994 10.1016/0091-3057(94)90284-4 Behavioral and biochemical effects of an ICV injection of Streptozotocin in old Lewis rats 

  34. Brain Res Prickaerts 674 142 1995 10.1016/0006-8993(95)00006-C Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: Effects of chronic treatment with acetyl-l-carnitine 

  35. J Neural Transm Nitsch 1 109 1989 10.1007/BF02312272 The intracerebroventricular streptozotocin-treated rat: Impairment of cerebral glucose metabolism of the brain in Alzheimer's disease 

  36. Psychiatry Res Davis 1 249 1979 10.1016/0165-1781(79)90006-4 Chronic parkinsonism secondary to intravenous injection of meperidine analogues 

  37. Trends Neurosci Garruto 9 368 1986 10.1016/0166-2236(86)90116-5 Neurodegenerative disorders of the western Pacific: The search for mechanisms of pathogenesis 

  38. Neurology Garruto 35 193 1985 10.1212/WNL.35.2.193 Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam 

  39. Lancet Spencer 2 1273 1987 10.1016/S0140-6736(87)91883-6 Cycad use and motor neurone disease in Irian Jaya 

  40. Lancet Spencer 2 1462 1987 10.1016/S0140-6736(87)91159-7 Cycad use and motor neurone disease in Kii peninsula of Japan 

  41. Gibbs 343 1982 Human Motor Neuron Diseases An update on long-term in vivo and in vitro studies designed to identify a virus as the cause of amyotrophic lateral sclerosis, Parkinsonism dementia, and Parkinson's disease 

  42. Kurland 165 1982 Human Motor Neuron Diseases Hereditary or acquired? 

  43. Neurobiol Aging Spencer 15 265 1994 10.1016/0197-4580(94)90129-5 On the etiology and pathogenesis of chemically induced neurodegenerative disorders 

  44. Neurology Ahlskog 45 1995 1340 Guamanian neurodegenerative disease: Investigations of the calcium metabolism/heavy metal hypothesis 

  45. Am J Epidemiol Reed 125 92 1987 10.1093/oxfordjournals.aje.a114515 A cohort study of amyotrophic lateral sclerosis and Parkinson-dementia on Guam and Rota 

  46. Spencer 263 1990 Amyotrophic Lateral Sclerosis: Concepts in Pathogenesis and Etiology Western Pacific amyotrophic lateral sclerosis: Putative role of cycad toxins 

  47. Kobayashi 31 1476 1972 Cycasin in cycad materials used in Japan 

  48. Endocrinology Eizirik 122 1242 1988 10.1210/endo-122-4-1242 Preferential reduction of insulin production in mouse pancreatic islets maintained in culture after Streptozotocin exposure 

  49. Mol Cell Endocrinol Strandell 59 83 1988 10.1016/0303-7207(88)90198-0 Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations 

  50. Endocrinology Eizirik 123 1001 1988 10.1210/endo-123-2-1001 Defective catabolism of d-glucose and l-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure 

  51. Acta Endocrinol (Copenh) Eizirik 121 849 1989 10.1530/acta.0.1210849 Persistent impairment of the insulin response to glucose both in vivo and in vitro after streptozotocin exposure: Studies with grafted pancreatic islets and islets maintained in culture 

  52. Diabetologia Inoue 37 351 1994 10.1007/BF00408470 Irreversible loss of normal beta-cell regulation by glucose in neonatally streptozotocin diabetic rats 

  53. Pharmacol Toxicol Eizirik 63 396 1988 10.1111/j.1600-0773.1988.tb00975.x Functional restoration of cultured mouse pancreatic islets after in vitro exposure to alloxan 

  54. Diabetes Eizirik 37 916 1988 10.2337/diab.37.7.916 Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin-1 

  55. J Mol Endocrinol Welsh 1 27 1988 10.1677/jme.0.0010027 Heat shock treatment of mouse pancreatic islets results in a partial loss of islet cells but no remaining functional impairment among the surviving β-cells 

  56. Diabetes Svensson 40 771 1991 10.2337/diab.40.6.771 Exhibition of specific alterations in activities and mRNA levels of rat islet glycolytic and mitochondrial enzymes in three different in vitro model systems for attenuated insulin release 

  57. Virchows Arch B Moreira 60 337 1991 10.1007/BF02899565 Decrease of insulin-containing secretory granules and mitochondrial gene expression in mouse pancreatic islets maintained in culture following streptozotocin exposure 

  58. Biochem Pharmacol Eizirik 42 2275 1991 10.1016/0006-2952(91)90230-3 Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of β-cells 

  59. Diabetologia Welsh 34 626 1991 10.1007/BF00400991 Decreased mitochondrial gene expression in isolated islets of rats injected neonatally with streptozotocin 

  60. Endocrinology Rasschaert 130 3522 1992 10.1210/endo.130.6.1534541 Long term in vitro effects of streptozotocin, interleukin-1, and high glucose concentration on the activity of mitochondrial dehydrogenases and the secretion of insulin in pancreatic islets 

  61. Int J Biochem Malaisse 24 693 1992 10.1016/0020-711X(92)90002-I Glucose-sensing by the pancreatic B-cell: The mitochondrial part 

  62. Diabetes LeDoux 37 1015 1988 10.2337/diab.37.8.1015 Mechanisms of nicotinamide protection from alloxan and streptozotocin toxicity 

  63. Diabetes Schnedl 43 1326 1994 10.2337/diab.43.11.1326 STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells 

  64. Cancer Res Bennet 41 2786 1981 Alkylation of DNA in rat tissues following administration of streptozotocin 

  65. Diabetes LeDoux 35 866 1986 10.2337/diab.35.8.866 Mechanisms of nitrosourea-induced B-cell damage. Alterations in DNA 

  66. Nature Yamamoto 294 284 1981 10.1038/294284a0 Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets 

  67. Mutat Res Anisimov 316 173 1995 10.1016/0921-8734(95)90003-9 Effect of aging and interval between primary and secondary treatment in carcinogenesis induced by neonatal exposure to 5-bromodeoxyuridine and subsequent administration of N-nitrosomethylurea in rats 

  68. Soc Neurosci Abstr Kisby 20 1649 1994 Potentiation of cycad toxin-induced DNA damage in brain tissue by DNA repair inhibitors 

  69. J Cell Sci Day 6 333 1987 10.1242/jcs.1984.Supplement_6.22 The role of O6-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis: A review 

  70. Diabetes Nelson 42 1187 1993 10.2337/diab.42.8.1187 Repair of O6-methylguanine in rat pancreatic β-cells after exposure to N-methyl-N-nitrosourea 

  71. J Cell Biochem Kisby 21A 348 1995 Role of DNA repair in protecting mature nervous tissue from DNA damage 

  72. J Cell Biochem Esclaire 21B 97 1995 The cycad toxin MAM enhances neuronal tau mRNA expression produced by glutamate 

  73. Biochem Biophys Res Commun Turk 197 1458 1993 10.1006/bbrc.1993.2641 Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets 

  74. FASEB J Kwon 8 529 1994 10.1096/fasebj.8.8.8181671 Nitric oxide generation from streptozotocin 

  75. Biol Chem Hoppe Seyler Kröncke 376 179 1995 10.1515/bchm3.1995.376.3.179 Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage 

  76. Biochim Biophys Acta Kröncke 1182 221 1993 10.1016/0925-4439(93)90144-P Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide 

  77. Carcinogenesis Ohshima 12 1217 1991 10.1093/carcin/12.7.1217 l-Arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-γ 

  78. Diabetes Corbett 41 897 1992 10.2337/diab.41.8.897 Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM 

  79. Diabetologia Kolb 35 796 1992 10.1007/BF00429103 Type 1 (insulin-dependent) diabetes mellitus and nitric oxide 

  80. Eizirik 91 9253 1994 Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury 

  81. J Clin Invest Eizirik 93 1968 1994 10.1172/JCI117188 Cytokines suppress human islet function irrespective of their effects on nitric oxide generation 

  82. Jpn J Genet Kato 55 99 1980 10.1266/jjg.55.99 Absence of correlation between DNA repair in ultraviolet irradiated mammalian cells and life span of the donor species 

  83. Mol Med Welsh 1 806 1995 10.1007/BF03401895 Differential expression of heat-shock proteins and antioxidant enzymes in isolated human and rodent pancreatic islets. Implications for pathogenesis of insulin-dependent diabetes mellitus 

  84. Diabetes Margulis 40 1418 1991 10.2337/diab.40.11.1418 Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1β-induced impaired β-cell function 

  85. J Clin Invest Bellman 95 2840 1995 10.1172/JCI117989 Heat shock induces resistance in rat pancreatic islets against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro 

  86. Diabetes Eizirik 42 1383 1993 10.2337/diab.42.10.1383 Repair of pancreatic β-cells. A relevant phenomenon in early IDDM? 

  87. Carcinogenesis Harris 10 1563 1989 10.1093/carcin/10.9.1563 Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair 

  88. Diabetologia Karvonen 36 883 1993 10.1007/BF02374468 A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus 

  89. Lancet Berne I 173 1974 10.1016/S0140-6736(74)92474-X Diabetogenic nitrosamines? 

  90. Diabetes Harlan 44 816 1995 10.2337/diab.44.7.816 Very-low dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice 

  91. Diabetes Res Kohnert 5 1 1987 Destruction of pancreatic beta cells in rats by complete Freund's adjuvant combined with non-diabetogenic doses of streptozotocin 

  92. Nature Med Beck 1 433 1995 10.1038/nm0595-433 Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates 

관련 콘텐츠

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트