[논문]The antihypertensive effect of orally administered nifedipine‐loaded nanoparticles in spontaneously hypertensive rats

Kim, Young Il; Fluckiger, Laurence; Hoffman, Maurice; Lartaud‐; Idjouadiene, Isabelle; Atkinson, Jeffrey; Maincent, Thilippe

doi:10.1038/sj.bjp.0700910

The antihypertensive effect of orally administered nifedipine‐loaded nanoparticles in spontaneously hypertensive rats 원문보기

British journal of pharmacology : BJP, v.120 no.3, 1997년, pp.399 - 404

Kim, Young Il , Fluckiger, Laurence , Hoffman, Maurice , Lartaud‐Idjouadiene, Isabelle , Atkinson, Jeffrey , Maincent, Thilippe

Abstract ▼ AI-Helper

The therapeutic use of nifedipine is limited by the rapidity of the onset of its action and its short biological half‐life. In order to produce a form devoid of these disadvantages we made nanoparticles of nifedipine from three different polymers, poly‐ɛ‐caprolactone (PCL), polylactic and glycolic acid (1:1) copolymers (PLAGA), and Eudragit RL/RS (Eudragit). Nifedipine in polyethylene glycol 400 (PEG) solution was used as a control.The average diameters of the nanoparticles ranged from 0.12 to 0.21 μm; the encapsulation ratio was 82% to 88%.In spontaneously hypertensive rats (SHR), the initial rapid fall in systolic arterial blood pressure following oral administration of nifedipine in PEG solution (from 193 ± 3 to 102 ± 2 mmHg) was not seen following administration of the same dose in Eudragit nanoparticles (from 189 ± 2 to 156 ± 2 mmHg); with PCL and PLAGA nanoparticles the initial fall in blood pressure was significantly reduced (nadirs PCL 124 ± 2 and PLAGA 113 ± 2 mmHg). Ten hours following administration, blood pressure in rats administered the nifedipine/PEG preparation had returned to normal (183 ± 3 mmHg) whereas that of animals given nifedipine in nanoparticles (PCL 170 ±3, PLAGA 168 ± 2, Eudragit 160 ±3 mmHg) was still significantly reduced.All of the nanoparticle dosage forms decreased Cmax and increased Tmax and the mean residence time (MRT) values. Relative bioavailability was significantly increased with Eudragit nanoparticles compared to the nifedipine/PEG solution.There was an inverse linear correlation between the fall in blood pressure and plasma nifedipine concentration with all preparations.The nanoparticle nifedipine preparations represent sustained release forms with increased bioavailability, a less pronounced initial antihypertensive effect and a long‐lasting action.

참고문헌 (28)

Al-Turk, W.A., Majeed, I.A., Murray, W.J., Newton, D.W., Othman, S.. Some factors affecting the photodecomposition of nifedipine. International journal of pharmaceutics, vol.41, no.3, 227-230.

상세보기
Beck, P., Scherer, D., Kreuter, J.. Separation of drug-loaded nanoparticles from free drug by gel filtration. Journal of microencapsulation, vol.7, no.4, 491-496.

상세보기
Bittar, N.. Usefulness of nifedipine for myocardial ischemia and the nifedipine gastrointestinal therapeutic system. The American journal of cardiology, vol.64, no.11, F31-F34.

상세보기
Bodmeier, R., Chen, H., Tyle, P., Jarosz, P.. Spontaneous formation of drug-containing acrylic nanoparticles. Journal of microencapsulation, vol.8, no.2, 161-170.

상세보기
Am. J. Hypertens. Bray L. 246S 4 1991 10.1093/ajh/4.3.246S Effect of angiotensin I converting enzyme inhibitor perindopril on cerebral blood flow in awake hypertensive rats
Chillon, Jean‐Marc, Capdeville‐Atkinson, Christine, Lartaud, Isabelle, Guillou, Joel, Mertès, Paul‐Michel, Atkinson, Jeffrey. Chronic antihypertensive treatment with captopril plus hydrochlorothiazide improves aortic distensibility in the spontaneously hypertensive rat. British journal of pharmacology : BJP, vol.107, no.3, 710-714.

상세보기
Fessi, H., Puisieux, F., Devissaguet, J.P., Ammoury, N., Benita, S.. Nanocapsule formation by interfacial polymer deposition following solvent displacement. International journal of pharmaceutics, vol.55, no.1, R1-R4.

상세보기
Proc. Int. Sym. Control. Rel. Bioac. Mat. Gilley R.M. 123 15 1988 Development of secretory and systemic immunity following oral administration of microencapsulated antigens
Grangier, J.L., Puygrenier, M., Gautier, J.C., Couvreur, P.. Nanoparticles as carriers for growth hormone releasing factor. Journal of controlled release : official journal of the Controlled Release Society, vol.15, no.1, 3-13.

상세보기
Grislain, L., Couvreur, P., Lenaerts, V., Roland, M., Deprez-Decampeneere, D., Speiser, P.. Pharmacokinetics and distribution of a biodegradable drug-carrier. International journal of pharmaceutics, vol.15, no.3, 335-345.

상세보기
Hubert, Brigitte, Atkinson, Jeffrey, Guerret, Madeleine, Hoffman, Maurice, Devissaguet, Jean Philippe, Maincent, Philippe. The Preparation and Acute Antihypertensive Effects of a Nanocapsular Form of Darodipine, a Dihydropyridine Calcium Entry Blocker. Pharmaceutical research, vol.8, no.6, 734-738.

상세보기
Kreuter, J., Muller, U., Munz, K.. Quantitative and microautoradiographic study on mouse intestinal distribution of polycyanoacrylate nanoparticles. International journal of pharmaceutics, vol.55, no.1, 39-45.

상세보기
Lehr, C.-M., Bouwstra, J.A., Tukker, J.J., Junginger, H.E.. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat-A comparative study with copolymers and blends based on poly(acrylic acid). Journal of controlled release : official journal of the Controlled Release Society, vol.13, no.1, 51-62.

상세보기
Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms Lehmann K.O.R. 153 1989
Proc. Int. Sym. Control. Rel. Bioact. Mat. Maincent P. 33 21 1994 Interest of colloidal carriers as vectors of antihypertensive dihydropyridine calcium‐entry blockers to decrease blood pressure in hypertensive rats
Makki, Touria, Talom, Rabelais Tatchum, Niederhoffer, Nathalie, Amin, Fatiha, Tankosic, Pierre, Mertès, Paul‐Michel, Atkinson, Jeffrey. Increased arterial distensibility induced by the angiotensin‐converting enzyme inhibitor, lisinopril, in normotensive rats. British journal of pharmacology : BJP, vol.111, no.2, 555-560.

상세보기
Miyazaki, K., Kohri, N., Arita, T., Shimono, H., Katoh, K., Nomura, A., Yasuda, H.. High-performance liquid chromatographic determination of nifedipine in plasma. Journal of chromatography. biomedical applications, vol.310, 219-222.

상세보기
J. Hypertension Myers M.G. S73 12 8 1994 Dihydropyridine calcium antagonists and the trough: peak ratio: focus on adverse effects
Eur. J. Hosp. Pharm. Ogawa Y. 120 2 1992 Monthly microcapsule‐depot form of LHRH agonist, leuprorelin acetate (Enantone® Depot): Formulation and pharmacokinetics in animals
Arzneim-Forsch/Drug Res. Pabst G. 256 36 1986 Pharmakinetics and bioavailability of three different galenic nifedipine preparations
Raemsch, K D, Sommer, J. Pharmacokinetics and metabolism of nifedipine.. Hypertension, vol.5, no.4,

상세보기
Sorkin, E.M., Clissold, S.P., Brogden, R.N.. Nifedipine A Review of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy, in Ischaemic Heart Disease, Hypertension and Related Cardiovascular Disorders :. Drugs, vol.30, no.3, 182-274.

상세보기
J. Anat. Tilney N.L. 369 109 1971 Patterns of lymphatic drainage in the adult laboratory rat

상세보기
J. Hypertension Van Zwieten P.A. S117 12 8 1994 Trough: peak ratio: measurement limitation and relevance to treatment of hypertension. Closing remarks
10.1016/S1054-3589(08)60188-X
Washington, C.. Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition. International journal of pharmaceutics, vol.56, no.1, 71-74.

상세보기
Washington, C.. Drug release from microdisperse systems: a critical review. International journal of pharmaceutics, vol.58, no.1, 1-12.

상세보기
J. Hypertension Zanchetti A. S97 12 8 1994 Trough: peak ratio of blood pressure response to dihydropyridine calcium antagnoists

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

The antihypertensive effect of orally administered nifedipine‐loaded nanoparticles in spontaneously hypertensive rats 원문보기

Abstract ▼ AI-Helper

참고문헌 (28)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트