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[해외논문] Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b 원문보기

Immunity, v.6 no.6, 1997년, pp.739 - 749  

Huang, Shuang (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Jiang, Yong (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Li, Zhuangjie (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Nishida, Eisuke (Institute of Virus Research, Kyoto University, Sakyo-ku, Kyoto, 606–) ,  Mathias, Patricia (01, Japan,) ,  Lin, Shengcai (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Ulevitch, Richard J (Institute of Molecular and Cell Biology, The National University of Singapore, Singapore, 119260, Singapore) ,  Nemerow, Glen R (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Han, Jiahuai (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractFas/APO-1(CD95) ligation activates programmed cell death, a cellular process that plays an important role in the maturation of the host immune response. We show that activation of a specific MAP kinase kinase (MKK), MKK6b, is necessary and sufficient for Fas-induced apoptosis of Jurkat T cel...

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