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Immunity, v.6 no.6, 1997년, pp.739 - 749
Huang, Shuang (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) , Jiang, Yong (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) , Li, Zhuangjie (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) , Nishida, Eisuke (Institute of Virus Research, Kyoto University, Sakyo-ku, Kyoto, 606–) , Mathias, Patricia (01, Japan,) , Lin, Shengcai (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) , Ulevitch, Richard J (Institute of Molecular and Cell Biology, The National University of Singapore, Singapore, 119260, Singapore) , Nemerow, Glen R (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA) , Han, Jiahuai (Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA)
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AbstractFas/APO-1(CD95) ligation activates programmed cell death, a cellular process that plays an important role in the maturation of the host immune response. We show that activation of a specific MAP kinase kinase (MKK), MKK6b, is necessary and sufficient for Fas-induced apoptosis of Jurkat T cel...
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