[논문]In vitro anti-junin virus activity of a peptide isolated from Melia azedarach L. leaves

doi:10.1016/S0924-8579(98)00011-9

In vitro anti-junin virus activity of a peptide isolated from Melia azedarach L. leaves

International journal of antimicrobial agents, v.10 no.1, 1998년, pp.67 - 75

Abstract ▼ AI-Helper

AbstractMeliacine, a peptide isolated from leaves of Melia azedarach L. inhibited the multiplication of Junin virus in Vero cells treated with the compound before infection (pre-treatment) or immediately after virus adsorption. Analysis of early events following infection demonstrated that meliacine blocks virus penetration by preventing the uncoating step. The addition of meliacine at different times after infection indicated that meliacine also interferes with the release of infectious particles to the extracellular medium and inhibits the low-pH-induced fusion of infected cells. Intracellular transport of viral glycoproteins to the cell membrane was not affected by meliacine, as revealed by immunofluorescence staining. Taken together, these results suggest that meliacine affects two events of the virus replicative cycle that require membrane fusion: uncoating and budding.

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참고문헌 (30)

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표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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In vitro anti-junin virus activity of a peptide isolated from Melia azedarach L. leaves

Abstract ▼ AI-Helper

주제어

참고문헌 (30)

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