$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma 원문보기

Cell, v.177 no.7, 2019년, pp.1842 - 1857.e21  

Lee, Jake June-Koo (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ,  Park, Seongyeol (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ,  Park, Hansol (Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology) ,  Kim, Sehui (Department of Pathology, Seoul National University College of Medicine) ,  Lee, Jongkeun (Clinical Genomics Analysis Branch, National Cancer Center) ,  Lee, Junehawk (Korea Institute of Science and Technology Information) ,  Youk, Jeonghwan (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ,  Yi, Kijong (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ,  An, Yohan (Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced) ,  Park, In Kyu ,  Kang, Chang Hyun ,  Chung, Doo Hyun ,  Kim, Tae Min ,  Jeon, Yoon Kyung ,  Hong, Dongwan ,  Park, Peter J. ,  Ju, Young Seok ,  Kim, Young Tae

Abstract AI-Helper 아이콘AI-Helper

Summary Mutational processes giving rise to lung adenocarcinomas (LADCs) in non-smokers remain elusive. We analyzed 138 LADC whole genomes, including 83 cases with minimal contribution of smoking-associated mutational signature. Genomic rearrangements were not correlated with smoking-associated mut...

주제어

참고문헌 (69)

  1. Nature Alexandrov 500 415 2013 10.1038/nature12477 Signatures of mutational processes in human cancer 

  2. Nat. Genet. Alexandrov 47 1402 2015 10.1038/ng.3441 Clock-like mutational processes in human somatic cells 

  3. Science Anderson 361 eaam8419 2018 10.1126/science.aam8419 Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors 

  4. Mol. Oncol. Aylon 5 315 2011 10.1016/j.molonc.2011.07.007 p53: guardian of ploidy 

  5. Cell Baca 153 666 2013 10.1016/j.cell.2013.03.021 Punctuated evolution of prostate cancer genomes 

  6. Nature Blokzijl 538 260 2016 10.1038/nature19768 Tissue-specific mutation accumulation in human adult stem cells during life 

  7. bioRxiv Campbell 2017 Pan-cancer analysis of whole genomes 

  8. Nature 511 543 2014 10.1038/nature13385 Comprehensive molecular profiling of lung adenocarcinoma 

  9. Nature 543 378 2017 10.1038/nature21386 Integrated genomic and molecular characterization of cervical cancer 

  10. eLife Carvalho 3 e02482 2014 10.7554/eLife.02482 SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint 

  11. JCO Precis. Oncol. Chakravarty 2017 10.1200/PO.17.00011 OncoKB: A precision oncology knowledge base 

  12. Nat. Genet. Chiang 44 390 2012 10.1038/ng.2202 Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration 

  13. Nat. Biotechnol. Cibulskis 31 213 2013 10.1038/nbt.2514 Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples 

  14. Science Engelman 316 1039 2007 10.1126/science.1141478 MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling 

  15. Ann. Oncol. Favero 26 64 2015 10.1093/annonc/mdu479 Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data 

  16. Cancer Cell Garsed 26 653 2014 10.1016/j.ccell.2014.09.010 The architecture and evolution of cancer neochromosomes 

  17. bioRxiv Gerstung 2017 The evolutionary history of 2,658 cancers 

  18. Cell Govindan 150 1121 2012 10.1016/j.cell.2012.08.024 Genomic landscape of non-small cell lung cancer in smokers and never-smokers 

  19. Nat. Genet. Haffner 42 668 2010 10.1038/ng.613 Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements 

  20. Nat. Rev. Genet. Helleday 15 585 2014 10.1038/nrg3729 Mechanisms underlying mutational signatures in human cancers 

  21. Adv. Anat. Pathol. Hendry 24 235 2017 10.1097/PAP.0000000000000162 

  22. Nature Herbst 553 446 2018 10.1038/nature25183 The biology and management of non-small cell lung cancer 

  23. Cell Imielinski 150 1107 2012 10.1016/j.cell.2012.08.029 Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing 

  24. Genes Dev. Jackson 15 3243 2001 10.1101/gad.943001 Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras 

  25. Cancer Cell Jaiswal 23 603 2013 10.1016/j.ccr.2013.04.012 Oncogenic ERBB3 mutations in human cancers 

  26. N. Engl. J. Med. Jamal-Hanjani 376 2109 2017 10.1056/NEJMoa1616288 Tracking the evolution of non-small-cell lung cancer 

  27. Cancer Cell Ji 9 485 2006 10.1016/j.ccr.2006.04.022 The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies 

  28. Genome Res. Ju 22 436 2012 10.1101/gr.133645.111 A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing 

  29. Sci. Transl. Med. Katayama 4 120ra17 2012 10.1126/scitranslmed.3003316 Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers 

  30. Hum. Mol. Genet. Kloosterman 20 1916 2011 10.1093/hmg/ddr073 Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline 

  31. Genome Res. Koboldt 22 568 2012 10.1101/gr.129684.111 VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing 

  32. Mod. Pathol. Koh 28 1154 2015 10.1038/modpathol.2015.63 Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status 

  33. J. Clin. Oncol. Lee 35 3065 2017 10.1200/JCO.2016.71.9096 Clonal history and genetic predictors of transformation into small-cell carcinomas from lung adenocarcinomas 

  34. Ann. Oncol. Lee 28 890 2017 10.1093/annonc/mdw686 Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma 

  35. Nucleic Acids Res. Lee 46 W1 W102 2018 10.1093/nar/gky406 Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures 

  36. Cell Maciejowski 163 1641 2015 10.1016/j.cell.2015.11.054 Chromothripsis and kataegis induced by telomere crisis 

  37. N. Engl. J. Med. Mehine 369 43 2013 10.1056/NEJMoa1302736 Characterization of uterine leiomyomas by whole-genome sequencing 

  38. Cell Mitchell 173 611 2018 10.1016/j.cell.2018.02.020 Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal 

  39. Nat. Rev. Cancer Mitelman 7 233 2007 10.1038/nrc2091 The impact of translocations and gene fusions on cancer causation 

  40. N. Engl. J. Med. Mok 361 947 2009 10.1056/NEJMoa0810699 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma 

  41. Cell Nik-Zainal 149 994 2012 10.1016/j.cell.2012.04.023 The life history of 21 breast cancers 

  42. Cell Park 166 950 2016 10.1016/j.cell.2016.07.005 Dual chromatin and cytoskeletal remodeling by SETD2 

  43. Cancer Cell Pfister 28 557 2015 10.1016/j.ccell.2015.09.015 Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation 

  44. Cell Rausch 148 59 2012 10.1016/j.cell.2011.12.013 Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations 

  45. Bioinformatics Rausch 28 i333 2012 10.1093/bioinformatics/bts378 DELLY: structural variant discovery by integrated paired-end and split-read analysis 

  46. Nat. Genet. Redin 49 36 2017 10.1038/ng.3720 The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies 

  47. Cancer Res. Saito 75 2264 2015 10.1158/0008-5472.CAN-14-3282 Development of lung adenocarcinomas with exclusive dependence on oncogene fusions 

  48. Cell Rep. Sakofsky 7 1640 2014 10.1016/j.celrep.2014.04.053 Break-induced replication is a source of mutation clusters underlying kataegis 

  49. Dev. Cell Santaguida 41 638 2017 10.1016/j.devcel.2017.05.022 Chromosome mis-segregation generates cell-cycle-arrested cells with complex karyotypes that are eliminated by the immune system 

  50. Bioinformatics Saunders 28 1811 2012 10.1093/bioinformatics/bts271 Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs 

  51. Genome Res. Seo 22 2109 2012 10.1101/gr.145144.112 The transcriptional landscape and mutational profile of lung adenocarcinoma 

  52. N. Engl. J. Med. Shaw 368 2385 2013 10.1056/NEJMoa1214886 Crizotinib versus chemotherapy in advanced ALK-positive lung cancer 

  53. Nat. Rev. Cancer Shaw 13 772 2013 10.1038/nrc3612 Tyrosine kinase gene rearrangements in epithelial malignancies 

  54. N. Engl. J. Med. Shaw 371 1963 2014 10.1056/NEJMoa1406766 Crizotinib in ROS1-rearranged non-small-cell lung cancer 

  55. Nature Soda 448 561 2007 10.1038/nature05945 Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer 

  56. Cell Stephens 144 27 2011 10.1016/j.cell.2010.11.055 Massive genomic rearrangement acquired in a single catastrophic event during cancer development 

  57. Nature Stratton 458 719 2009 10.1038/nature07943 The cancer genome 

  58. Nat. Rev. Cancer Sun 7 778 2007 10.1038/nrc2190 Lung cancer in never smokers--a different disease 

  59. Science Tomasetti 355 1330 2017 10.1126/science.aaf9011 Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention 

  60. Nature Turner 543 122 2017 10.1038/nature21356 Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity 

  61. Cancer Cell Vaz 32 360 2017 10.1016/j.ccell.2017.08.006 Chronic cigarette smoke-induced epigenomic changes precede sensitization of bronchial epithelial cells to single-step transformation by KRAS mutations 

  62. Nat. Commun. Wang 9 2054 2018 10.1038/s41467-018-04492-2 Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients 

  63. Cancer Cell Wilson 27 397 2015 10.1016/j.ccell.2015.02.005 A functional landscape of resistance to ALK inhibition in lung cancer 

  64. Nat. Commun. Wu 6 10131 2015 10.1038/ncomms10131 Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas 

  65. Nature Yokoyama 565 312 2019 10.1038/s41586-018-0811-x Age-related remodelling of oesophageal epithelia by mutated cancer drivers 

  66. Nat. Med. Zehir 23 703 2017 10.1038/nm.4333 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients 

  67. Genes Dev. Zhang 27 2513 2013 10.1101/gad.229559.113 Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements 

  68. Nature Zhang 522 179 2015 10.1038/nature14493 Chromothripsis from DNA damage in micronuclei 

  69. Cell Zhu 166 1132 2016 10.1016/j.cell.2016.07.045 Multi-organ mapping of cancer risk 

LOADING...

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로