[논문]Study on the pharmacodynamics and metabolomics of five medicinal species in Atractylodes DC. on rats with rheumatoid arthritis

Liu, Yuqiang; Zhang, Beixue; Cai, Qian

doi:10.1016/j.biopha.2020.110554

Study on the pharmacodynamics and metabolomics of five medicinal species in Atractylodes DC. on rats with rheumatoid arthritis 원문보기

Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie, v.131, 2020년, pp.110554 -

Liu, Yuqiang (Corresponding author.) , Zhang, Beixue , Cai, Qian

Abstract ▼ AI-Helper

Abstract Atractylodes DC. mainly includes Atractylodis Rhizoma and Atractylodis macrocephalae Rhizoma. According to Chinese Pharmacopoeia, Atractylodis Rhizoma is the rhizome of Atractylodes lancea (Thunb.) DC. (A. lancea) and Atractylodes chinensis (DC.) Koidz. (A. chinensis), while Atractylodis macrocephalae Rhizoma is the rhizome of Atractylodes macrocephala Koidz. (A. macrocephala). Although Atractylodes japonica Koidz. ex Kitam. (A. japonica) and Atractylodes coreana (Nakai) Kitam. (A. coreana) are not included in the Pharmacopoeia, they are often used as Atractylodis Rhizoma in northern China. But in Japan, A. japonica is used as Atractylodis macrocephalae Rhizoma. In order to compare the efficacy of A. japonica and A. coreana with that of Atractylodis Rhizoma and Atractylodis macrocephalae Rhizomain in Pharmacopoeia, this paper studies the anti rheumatism of the five medicinal species in Atractylodes DC., and provides the basis for the rational application of A. japonica and A. coreana. With this purpose, the rheumatoid model of rats was established by Freund's complete adjuvant. Then, Enzyme-linked immunosorbent assay (ELISA) was used to determine the contents of interleukin-6 (IL-6), tumor necrosis factor-α (TNF - α), arthritis factor (RF), anti cyclic citrullinated peptide (anti-CCP), interleukin-1β (IL-1β), Nuclear factor-κB (NF - κB), interleukin-10 (IL-10) and Prostaglandin E2 (PGE2) in rats of each group. Ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) was used to analyze the plasma of each group. After that, multivariate statistical analysis method was used to analyze the data. The results showed that the five medicinal species in Atractylodes DC. can reduce the levels of IL-6, IL-1 β, PGE2 and NF - κB in the plasma of rheumatoid arthritis (RA) rats in varying degrees, among which the regulation of A. macrocephala is relatively weak. A. chinensis, A. lancea, A. coreana and A. japonica can significantly reduce the content of TNF - α, in which A. japonica and A. lancea have better and similar regulatory effects. A. chinensis and A. coreana can significantly reduce the content of RF in arthritis rats. A. coreana, A. lancea and A. japonica can significantly reduce the anti-CCP level, that is, the regulatory effect of A. coreana and A. chinensis is similar. The metabolic disorder of 11-deoxycortisol, taurocholate and other small molecules in the body of rats with RA directly affects the metabolic pathways of primary bile acid biosynthesis and steroid hormone biosynthesis, leading to the decline of immune function and other symptoms. Most of the metabolic pathways tend to be normal after oral administration of five medicinal species in Atractylodes DC. Among them, the regulating effect of A. coreana and A. chinensis is similar, while that of A. japonica and A. lancea are similar. A. macrocephala had little effect of intervention. Highlights In the aspect of anti rheumatism, the effect of A. japonica and A. coreana is closer to that of Atractylodis Rhizoma. A. coreana and A. chinensis have better and similar therapeutic effects on rheumatoid arthritis. A. japonica and A. lancea are more similar in the treatment of rheumatoid arthritis. Rheumatoid arthritis causes changes in two metabolic pathways: primary bile acid biosynthesis and steroid hormone biosynthesis. Graphical abstract [DISPLAY OMISSION]

주제어

참고문헌 (38)

Arthritis Res. Ther. Huffman 19 1 12 2017 10.1186/s13075-016-1215-7 Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

상세보기
Nat. Rev. Rheumatol. Walsh 10 10 581 2014 10.1038/nrrheum.2014.64 Mechanisms, impact and management of pain in rheumatoid arthritis

상세보기
Best Pract. Res. Clin. Rheumatol. Deane 27 4 87 2013 10.1016/j.berh.2013.09.002 Can rheumatoid arthritis be prevented

상세보기
Ann. Rheum. Dis. Ramiro 73 3 529 2014 10.1136/annrheumdis-2013-204575 Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis

상세보기
Shanghai J. Immunol. Sheng 04 2002 The therapeutic and prophylactic effects of Zaocys Dhumnades (Cantor) hydrolysates on collagen-induced arthtitis
Chinese Pharmacopoeia Commission 2015 Pharmacopoeia of the People’s Republic of China
Arch. Pharm. Res. Duan 31 965 2008 10.1007/s12272-001-1252-z A new cytotoxic prenylated dihydrobenzofuran derivative and other chemical constituents from the rhizomes of Atractylodes lancea DC

원문보기 상세보기
J. Ethnopharmacol. Nakai 84 51 2003 10.1016/S0378-8741(02)00260-X Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying

상세보기
Planta Med. Resch 67 437 2001 10.1055/s-2001-15817 Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti inflammatory activity

상세보기
Editorial board of Japan Pharmaceutical Administration 1605 2006 The Japanese Pharmacopoeia Fifteenth Edition
Anal. Chem. Kirwan 84 7064 2012 10.1021/ac301269r Building multivariate systems biology models

상세보기
J. Pharm. Biomed. Anal. Zhou 127 60 2016 10.1016/j.jpba.2016.02.004 Exploration of the serum metabolite signature in patients with rheumatoid arthritis using gas chromatography-mass spectrometry

상세보기
Autoimmun. Rev. Priori 12 1022 2013 10.1016/j.autrev.2013.04.002 Metabolomics in rheumatic diseases: the potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy

상세보기
J. Pharm. Biomed. Anal. Kordalewska 113 121 2015 10.1016/j.jpba.2015.04.021 Metabolomics in cardiovascular diseases

상세보기
World Chin. Med. Wang 13 04 2018 Effect of total flavonoids of Herba Taxilli on adjuvant arthritis in rats
Nat. Protoc. Dunn 6 7 1060 2011 10.1038/nprot.2011.335 Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

상세보기
Anal. Chem. Smith 78 3 779 2006 10.1021/ac051437y XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

상세보기
Chin. J. Clin. Pharm. Ther. J.Y. A 15 05 481 2010 Data processing method of metabonomics - principal component analysis
Acta Pharm. Sin. Xue 50 03 340 2015 UPLC/Q-TOF MS and NMR plant meta bolomics approach in studying the effect of growth year on the quality of Polygala tenuifolia
J. Chin. Pharm. Sci. Liu 21 569 2012 10.5246/jcps.2012.06.072 Characterization of chemical constituents and in vivo metabolites of Kai-Xin-San prescripttion by HPLC/DAD/ESI-MS n
J. Agric. Food Chem. Lee 58 10582 2010 10.1021/jf102415m Geographical and climatic dependencies of green tea (Camellia sinensis) metabolites: a 1 H NMR-based metabolomics study

상세보기
J. Agric. Food Chem. Son 57 1481 2009 10.1021/jf803388w Metabolomic studies on geographical grapes and their wines using 1 H NMR analysis coupled with multivariate statistics

상세보기
J. Pharm. Biomed. Anal. Tarachiwin 48 42 2008 10.1016/j.jpba.2008.04.025 Quality evaluation of Angelica acutiloba Kitagawa roots by 1 H NMR-based metabolic fingerprinting

상세보기
J. Agric. Food Chem. Consonni 57 4506 2009 10.1021/jf804004z Triple concentrated tomato paste: discrimination between Italian and Chinese products

상세보기
Chin. J. Basic Med. Trad. Chin. Med. Li 13 6 428 2007 Effect and mechanism of Tongxinluo Capsule on adjuvant arthritis
Arthritis Rheum. Jacobson 42 10 2060 1999 10.1002/1529-0131(199910)42:10<2060::AID-ANR6>3.0.CO;2-L A new spin on an old model: on vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory and parameters and histo-pathology in the adjuvant arthritis rat

상세보기
Inflamm. Res. Hu 61 8 827 2012 10.1007/s00011-012-0477-z Recombinant human en-dostatin inhibits adjuvant arthritis by down -regulating VEGF expression and suppression of TNF-α, IL-1β production

상세보기
Mediators Inflamm. Yoo 2016 75 2016 10.1155/2016/8742562 Inhibitory effect of Loranthus parasiticus on IgE-mediated allergic responses in RBL-2H3 cells

상세보기
Evid. Based Complement. Altern. Med. Weon 2014 130 2014 10.1155/2014/860180 The effects of loran-thus parasiticus on scopolamine-induced memory impairment in mice

상세보기
J. Nat. Med. Wong 66 3 97 2012 10.1007/s11418-011-0622-y Neuroprotective properties of Loranthus parasiticus aqueous fraction against oxidative stress-induced damage in NG108-15 cells

상세보기
Arthritis Rheum. Deane 62 11 3161 2010 10.1002/art.27638 The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age ‐dependent manner

상세보기
Arthritis Res. Ther. Kokkonen 13 1 R13 2011 10.1186/ar3237 Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

상세보기
Arthritis Rheum. Kokkonen 62 2 383 2010 10.1002/art.27186 Up ‐ regulation of cytokines and chemokines predates the onset of rheumatoid arthritis

상세보기
Pharmacol. Clin. Chin. Mater. Med. Ju 4 04 2014 Study on the rat model of arthritis induced by complete Freund’s adjuvant with cyclic citrulline peptide
Arch. Med. Res. Abdollahzad 46 7 527 2015 10.1016/j.arcmed.2015.08.006 Effects of coenzyme Q10 supplementation on inflammatory cytokines (TNF- α, IL-6) and oxidative stress in rheumatoid arthritis patients: a randomized controlled trial

상세보기
Inner Mongolia Agric. Univ. Cao 2001 Anti inflammatory effect of cholic acid and its pharmacological and histological effects on respiratory system
Zhejiang Chin. Med. Univ. Zhu 2015 A Study of the relationship between kidney- yang deficiency rats induced by adenine and serum steroids hormones
Ann. Rheum. Dis. Cutolo 57 573 1998 10.1136/ard.57.10.573 Relations between steroid hormones and cytokines in rheumatoid arthritis and systemic lupus erythematosus

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Study on the pharmacodynamics and metabolomics of five medicinal species in Atractylodes DC. on rats with rheumatoid arthritis 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (38)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트