[논문]Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats

Kim, Jihee; Kim, Min-Jeong; Lee, Jin-Ho; Woo, Keunjung; Kim, Minah; Kim, Tack-Joong

doi:10.1155/2021/6643345

Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats 원문보기

Evidence-based Complementary and Alternative Medicine : eCAM, v.2021, 2021년, pp.6643345 -

Kim, Jihee (Division of Biological Science and Technology, College of Science and Technology Convergence, Yonsei University, Wonju 26493, Republic of Korea) , Kim, Min-Jeong (Division of Biological Science and Technology, College of Science and Technology Convergence, Yonsei University, Wonju 26493, Republic of Korea) , Lee, Jin-Ho (Division of Biological Science and Technology, College of Science and Technology Convergence, Yonsei University, Wonju 26493, Republic of Korea) , Woo, Keunjung (Division of Biological Science and Technology, College of Science and Technology Convergence, Yonsei University, Wonju 26493, Republic of Korea) , Kim, Minah (Division of Biological Science and Technology, College of Science and Technology Convergence, Yonsei University, Wonju 26493, Republic of Korea) , Kim, Tack-Joong (Division of Biological Science and Technology, College of Science and Technology Convergence, Yonsei University, Wonju 26493, Republic of Korea)

Abstract ▼ AI-Helper

The effects of the Cichorium intybus root extract (Cii) on alcohol-induced liver disease were investigated using Chang liver cells and male Sprague Dawley rats. Silymarin, a liver-protective agent, was used as a positive control. In cell experiments, after 24 h of treatment with the extract, no cytotoxicity was noted, and death by alcohol was avoided. Migration of Chang liver cells increased after exposure to the extract at a concentration of 400 μg/mL. In animal experiments, alcohol was injected into 6-week-old rats for 1, 3, and 50 days. Oral administration of the drug was performed 30 min before alcohol administration. The control was treated with distilled water, and the drug groups were administered EtOH (40% EtOH + 2.5 mL/kg), EtOH + Cii L (low concentration, 2 mg/kg), EtOH + Cii H (high concentration, 10 mg/kg), or EtOH + silymarin (100 mg/kg). Increased liver weight was observed in the alcohol group, as were increased blood-alcohol concentration and liver damage indicators (glutamic oxalacetic transaminase (GOT), glutamic pyruvate transaminase (GPT), and triglycerides (TG)), decreased alcoholysis enzymes (ADH and ALDH), and increased CYP2E1. In the Cii treatment group, liver weight, blood-alcohol concentration, liver damage indicators (GOT, GPT, and TG), and CYP2E1 were decreased, while alcoholysis enzymes (ADH and ALDH) were increased. The degree of histopathological liver damage was compared visually and by staining with hematoxylin and eosin and oil red O. These results indicated that ingestion of Cii inhibited alcohol-induced liver damage, indicating Cii as a useful treatment for alcohol-induced liver injury.

참고문헌 (32)

1 Lee S.-E. Lee J.-H. Kim G.-S. Effect of root extract of Lythrum salicaria L. on liver function of rat acutely administrated with alcohol Korean Journal of Medicinal Crop Science 2012 20 5 345 352
2 Stickel F. Datz C. Hampe J. Bataller R. Pathophysiology and management of alcoholic liver disease: update 2016 Gut and Liver 2017 11 2 p. 173
3 Jameson J. L. Harrison’s Principles of Internal Medicine 2018 New York, NY, USA McGraw-Hill Education
4 Xu L. Yu Y. Sang R. Li J. Ge B. Zhang X. Protective effects of taraxasterol against ethanol-induced liver injury by regulating CYP2E1/Nrf2/HO-1 and NF- κ B signaling pathways in mice Oxidative Medicine and Cellular Longevity 2018 2018 11 8284107 10.1155/2018/8284107 2-s2.0-85055078078

상세보기
5 Du J. He D. Sun L.-N. Semen Hoveniae extract protects against acute alcohol-induced liver injury in mice Pharmaceutical Biology 2020 48 8 953 958
6 Ronis M. Huang J. Crouch J. Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats Journal of Pharmacology And Experimental Therapeutics 1993 264 2 944 950

상세보기
7 Li S. Wang N. Hong M. Tan H.-Y. Pan G. Feng Y. Hepatoprotective effects of a functional formula of three Chinese medicinal herbs: experimental evidence and network pharmacology-based identification of mechanism of action and potential bioactive components Molecules 2019 23 2 p. 352
8 Lieber C. S. Alcohol and the liver: 1984 update Hepatology 1994 4 6 1243 1260
9 Nagappan A. Kim J.-H. Jung D. Y. Jung M. H. Cryptotanshinone from the salvia miltiorrhiza bunge attenuates ethanol-induced liver injury by activation of AMPK/SIRT1 and Nrf2 signaling pathways International Journal Of Molecular Sciences 2019 21 1 p. 265
10 Rouach H. Clément M. Orfanelli M.-T. Janvier B. Nordmann J. Nordmann R. Hepatic lipid peroxidation and mitochondrial susceptibility to peroxidative attacks during ethanol inhalation and withdrawal Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1983 753 3 439 444 6684482

상세보기
11 Moncada C. Torres V. Varghese G. Albano E. Israel Y. Ethanol-derived immunoreactive species formed by free radical mechanisms Molecular Pharmacology 1994 46 4 786 791 7969061

상세보기
12 Nagappan A. Jung D. Y. Kim J.-H. Lee H. Jung M. H. Gomisin N alleviates ethanol-induced liver injury through ameliorating lipid metabolism and oxidative stress International Journal of Molecular Sciences 2018 19 9 p. 2601
13 Shi C. Wang Y. Gao J. Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines Molecular Medicine Reports 2017 16 3 2767 2772 28677809

상세보기
14 Shin S. Park S.-S. Lee H.-M. Hur J.-M. Effects of fermented chicory fiber on the improvement of intestinal function and constipation Journal of the Korean Society of Food Science and Nutrition 2021 43 1 55 59
15 Ohashi K. Pimienta M. Seki E. Alcoholic liver disease: a current molecular and clinical perspective Liver Research 2018 2 4 161 172 31214376

상세보기
16 Kim N. H. Sung S. H. Heo J. D. Jeong E. J. The extract of Limonium tetragonum protected liver against acute alcohol toxicity by enhancing ethanol metabolism and antioxidant enzyme activities Natural Product Sciences 2015 21 1 54 58

원문보기 상세보기
17 Chen C. Wen D. C. Gao S. D. Hu X. Y. Yi C. The protective effects of Buzui on acute alcoholism in mice Evidence-Based Complementary and Alternative Medicine: ECAM 2016 2016 8 3539748 10.1155/2016/3539748 2-s2.0-84958794104

상세보기
18 Lee J.-S. Kim N.-Y. Lee K.-H. Effects of flower of Pueraria lobata on lipid peroxidation and activities of alcohol metabolic enzymes in alcohol-treated rats Joural Korean Society of Food Science and Nutrition 2020 29 5 935 942
19 Louvet A. Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment Nature Reviews. Gastroenterology and Hepatology 2015 12 4 p. 231
20 Lieber C. S. Alcohol and the liver: 1994 update Gastroenterology 1994 106 4 1085 1105 8143977
21 Cha Y.-S. Choi D.-S. Oh S.-H. Effects of Angelica gigas Nakai diet on lipid metabolism, alcohol metabolism and liver function of rats administered with chronic ethanol Applied Biological Chemistry 1999 42 1 29 33
22 Gruchow H. W. Sobocinski K. A. Barboriak J. J. Scheller J. G. Alcohol consumption, nutrient intake and relative body weight among US adults The American Journal of Clinical Nutrition 1985 42 2 289 295 4025199

상세보기
23 Pikaar N. A. Wedel M. Van Der Beek E. J. Effects of moderate alcohol consumption on platelet aggregation, fibrinolysis, and blood lipids Metabolism 1998 36 6 538 543
24 Lieber C. S. Alcohol and the liver: metabolism of ethanol, metabolic effects and pathogenesis of injury Acta Medica Scandinavica 1985 218 S703 11 55
25 Cao Y.-W. Jiang Y. Zhang D.-Y. Protective effects of penthorum Chinense pursh against chronic ethanol-induced liver injury in mice Journal of Ethnopharmacology 2015 161 92 98 25510733

상세보기
26 Mezey E. Alcoholic liver disease: roles of alcohol and malnutrition The American Journal of Clinical Nutrition 1980 33 12 2709 2718 7001889

상세보기
27 Lieber C. S. Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases The Mount Sinai Journal of Medicine 2000 67 1 84 94 10677787

상세보기
28 Zeman F. Liver Disease and Alcoholism in Clinical Nutrition and Dietetics Lexington, MA, USA D. C. Heath 1983
29 Lieber C. S. Cytochrome P-4502E1: its physiological and pathological role Physiological Reviews 1997 77 2 517 544 9114822

상세보기
30 Jimenez-Lopez J. M. Cederbaum A. I. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury Expert Opinion on Drug Metabolism and Toxicology 2003 1 4 671 685
31 Leung T.-M. Nieto N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease Journal of Hepatology 2013 58 2 395 398 22940046

상세보기
32 Kong X. Yang Y. Ren L. Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling Scientific Reports 2017 7 1 1 12 28127051

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Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats 원문보기

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Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats 원문보기

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