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NTIS 바로가기EMC. Maladies infectieuses, v.1 no.1, 2004년, pp.10 - 20
Lelièvre, J.-D (Service d’immunologie clinique, Inserm U421, Hô) , Morinet, F (pital Henri Mondor,51, avenue du Maré) , Pillet, S (chal-de-Lattre-de-Tassigny, 94010 Cré)
AbstractB19 parvovirus is transmitted via the respiratory route. Its target cells are the erythroid precursors BFU-E, CFU-E. Infection of such cells result in bone marrow suppression, which can be inapparent in normal individuals but may result in transient aplastic crisis in subjects with chronic h...
RésuméLe parvovirus B19 est un virus nu très résistant aux procédés d’inactivation, se transmettant par voie respiratoire, notamment lors d’épidémies saisonnières. Le B19 a un tropisme particulier pour les cellules hématopoïétiques érythroïdes dont l’expression sera variable suivant l'état hémato-immunologique de l'hôte. Les patients présentant une hémolyse chronique, ou le fœtus, présenteront des épisodes d’anémie aiguë du fait d’un taux de renouvellement érythrocytaire plus important que chez l’adulte ; l’infection aboutira, en revanche, à une anémie chronique chez les patients incapables de produire une réponse humorale anti-B19. En l’absence de telles pathologies, l’infection par le B19 peut s’accompagner de signes cutanés, mégalérythème chez l’enfant, ou arthropathies aiguës chez l’adulte, manifestations relevant essentiellement d’un mécanisme immunologique. La responsabilité du B19 dans la survenue d’authentiques connectivites ou vascularites reste à préciser. Il n’en demeure pas moins que l’infection par le B19 peut prendre l’aspect clinique et biologique de telles affections et doit être évoquée devant un tableau aigu associant des signes d’atteintes articulaires et cutanées, et la présence d’autoanticorps. Il n’existe pas de traitement spécifique de l’infection par le B19 qui repose sur l’utilisation de transfusions en cas d’anémie aiguë, et sur la perfusion d’immunoglobulines polyvalentes en cas d’anémie chronique secondaire à un déficit immunitaire.
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