Keratoacanthoma is a rapidly growing tumor, histologically resembling squamous cell carcinoma. Although it may regress spontaneously, keratoacanthoma is routinely treated by excision. Here we report the successful therapeutic use of imiquimod 5% cream for the treatment of keratoacanthoma. The patient was 35-year old Korean man with solitary dome-shaped nodule on his nose. On the basis of clinical and histopathological examination, the diagnosis of solitary keratoacanthoma of mature stage was made. The tumor mass fully regressed under topical treatment with imiquimod 5% cream within 38 days. No recurrence occurred during a six months follow up period. Imiquimod can be an effective non-operative therapeutic modality for keratoacanthoma.
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