Epithelioid hemangioendothelioma is a rare tumor of vascular endothelium that is considered to be of borderline malignancy. Typical sites of involvement include soft tissue and less frequently, liver and lung. A 45-year-old woman had found a nodule on left second finger. There were no specific personal or family history. Physical examination revealed a 0.7x0.7cm sized skin-colored hard nodule on the dorsum of the distal interphalangeal joint of left second finger. There were no lymphadenopathy, hepatosplenomegaly, or bone tenderness. The patient underwent an excision of the lesion. On microscopic examination, a moderately well-circumscribed nodule composed of sheets and cords of epithelioid cells, many of which possessed intracytoplasmic lumina, was noted in the dermis. Erythrocytes were seen within some of the lumina. On immunohistochemical staining, the cells showed positive staining for factor VIII-related antigen and smooth muscle actin, and negative staining for CD31, CD34 and S-100.
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