$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Aldosterone Upregulates Connective Tissue Growth Factor Gene Expression via p38 MAPK Pathway and Mineralocorticoid Receptor in Ventricular Myocytes 원문보기

Journal of Korean medical science : JKMS, v.19 no.6 = no.100, 2004년, pp.805 - 811  

Lee, Young-Sam (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.) ,  Kim, Jeong-A (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.) ,  Kim, Koung Li (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.) ,  Jang, Hyung-Suk (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.) ,  Kim, Jeong-Min (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.) ,  Lee, Jae-Young (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.) ,  Shin, In-Soon (Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School) ,  Lee, Jung-Sun ,  Suh, Wonhee ,  Choi, Jin-Ho ,  Jeon, Eun-Seok ,  Byun, Jonghoe ,  Kim, Duk-Kyung

Abstract AI-Helper 아이콘AI-Helper

The effect of aldosterone on connective tissue growth factor (CTGF) was examined in rat embryonic ventricular myocytes. Upon aldosterone treatment, CTGF expression was significantly increased in a dose and time-dependent manner. To explore the molecular mechanism for this upregulation, we examined t...

주제어

참고문헌 (34)

  1. 1 Young M Funder JW Aldosterone and the heart Trends Endocrinol Metab 2000 11 224 226 10878752 

  2. 2 Robert V van Thiem N Cheav SL Mouas C Swynghedauw B Delcayre C Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension Hypertension 1994 24 30 36 8021005 

  3. 3 Robert V Silvestre JS Charlemagne D Sabri A Trouve P Wassef M Swynghedauw B Delcayre C Biological determinants of aldosterone-induced cardiac fibrosis in rats Hypertension 1995 26 971 978 7490157 

  4. 4 Brilla CG Zhou G Matsubara L Weber KT Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone J Mol Cell Cardiol 1994 26 809 820 7966349 

  5. 5 Fullerton MJ Funder JW Aldosterone and cardiac fibrosis: in vitro studies Cardiovasc Res 1994 28 1863 1867 7867040 

  6. 6 Zhou G Kandala JC Tyagi SC Katwa LC Weber KT Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts Mol Cell Biochem 1996 154 171 178 8717431 

  7. 7 Stockand JD Meszaros JG Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling Am J Physiol-Heart Circ Physiol 2003 284 H176 H184 12388314 

  8. 8 Weber KT Aldosterone in congestive heart failure N Engl J Med 2001 345 1689 1697 11759649 

  9. 9 Silvestre JS Robert V Heymes C Aupetit-Faisant B Mouas C Moalic JM Swynghedauw B Delcayre C Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation J Biol Chem 1998 273 4883 4891 9478930 

  10. 10 Pitt B Zannad F Remme WJ Cody R Castaigne A Perez A Palensky J Wittes J The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators N Engl J Med 1999 341 709 717 10471456 

  11. 11 Bradham DM Igarashi A Potter RL Grotendorst GR Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10 J Cell Biol 1991 114 1285 1294 1654338 

  12. 12 Kothapalli D Frazier KS Welply A Segarini PR Grotendorst GR Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway Cell Growth Differ 1997 8 61 68 8993835 

  13. 13 Nakanishi T Kimura Y Tamura T Ichikawa H Yamaai Y Sugimoto T Takigawa M Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA Biochem Biophys Res Commun 1997 234 206 210 9168990 

  14. 14 Hishikawa K Nakaki T Fujii T Transforming growth factor-beta (1) induces apoptosis via connective tissue growth factor in human aortic smooth muscle cells Eur J Pharmacol 1999 385 287 290 10607888 

  15. 15 Brigstock DR The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family Endocr Rev 1999 20 189 206 10204117 

  16. 16 Lasky JA Ortiz LA Tonthat B Hoyle GW Corti M Athas G Lungarella G Brody A Friedman M Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis Am J Physiol - Lung Cell Mol Physiol 1998 275 L365 L371 

  17. 17 Ito Y Aten J Bende RJ Oemar BS Rabelink TJ Weening JJ Goldschmeding R Expression of connective tissue growth factor in human renal fibrosis Kidney Int 1998 53 853 861 9551391 

  18. 18 Paradis V Dargere D Vidaud M De Gouville AC Huet S Martinez V Gauthier JM Ba N Sobesky R Ratziu V Bedossa P Expression of connective tissue growth factor in experimental rat and human liver fibrosis Hepatology 1999 30 968 976 10498649 

  19. 19 Igarashi A Nashiro K Kikuchi K Sato S Ihn H Fujimoto M Grotendorst GR Takehara K Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders J Invest Dermatol 1996 106 729 733 8618012 

  20. 20 Grotendorst GR Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts Cytokine Growth Factor Rev 1997 8 171 179 9462483 

  21. 21 Ohnishi H Oka T Kusachi S Nakanishi T Takeda K Nakahama M Doi M Murakami T Ninomiya Y Takigawa M Tsuji T Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats J Mol Cell Cardiol 1998 30 2411 2422 9925376 

  22. 22 Chen MM Lam A Abraham JA Schreiner GF Joly AH CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis J Mol Cell Cardiol 2000 32 1805 1819 11013125 

  23. 23 Blasi ER Rocha R Rudolph AE Blomme EA Polly ML McMahon EG Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats Kidney Int 2003 63 1791 1800 12675855 

  24. 24 Brilla CG Matsubara LS Weber KT Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism J Mol Cell Cardiol 1993 25 563 575 8377216 

  25. 25 Nicoletti A Heudes D Hinglais N Appay MD Philippe M Sassy-Prigent C Bariety J Michel JB Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone Hypertension 1995 26 101 111 7607712 

  26. 26 Davis RJ The mitogen-activated protein kinase signal transduction pathway J Biol Chem 1993 268 14553 14556 8325833 

  27. 27 Alessi DR Cuenda A Cohen P Dudley DT Saltiel AR PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo J Biol Chem 1995 270 27489 27494 7499206 

  28. 28 Cuenda A Rouse J Doza YN Meier R Cohen P Gallagher TF Young PR Lee JC SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 FEBS Lett 1995 364 229 233 7750577 

  29. 29 Barr RK Kendrick TS Bogoyevitch MA Identification of the critical features of a small peptide inhibitor of JNK activity J Biol Chem 2002 277 10987 10997 11790767 

  30. 30 Gumz ML Popp MP Wingo CS Cain BD Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line Am J Physiol - Renal Physiol 2003 285 F664 F673 12770840 

  31. 31 Cohen P Dissection of protein kinase cascades that mediate cellular response to cytokines and cellular stress Adv Pharmacol 1996 36 15 27 8783552 

  32. 32 English J Pearson G Wilsbacher J Swantek J Karandikar M Xu S Cobb MH New insights into the control of MAP kinase pathways Exp Cell Res 1999 253 255 270 10579927 

  33. 33 Matsuoka H Arai T Mori M Goya S Kida H Morishita H Fujiwara H Tachibana I Osaki T Hayahi S A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis Am J Physiol - Lung Cell Mol Physiol 2002 283 L103 L112 12060566 

  34. 34 Oshima Y Fujio Y Funamoto M Negoro S Izumi M Nakaoka Y Hirota H Yamauchi-Takihara K Kawase I Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway FEBS Lett 2002 524 123 126 12135753 

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로