Multinucleate cell angiohistiocytoma (MCAH) is a rare benign fibrohistiocytic vascular condition that usually occurs on the extremities of elderlies women as discrete, grouped, red-brown papules and coalescing plaques. MCAH is characterized histologically by dermal vascular proliferation, bizarre multinucleate cells, and a sparse lymphohistiocytic infiltrate. Herein, we report a 61-year-old man presented with an asymptomatic 1.6x3.3cm sized, erythematous verrucous plaque under the left lower eyelid for 5 months. Histopathologic examination revealed variable-sized, proliferative, dilated dermal vessels lined by plump endothelial cells and interspersed multinucleated cells among these vascular channels. Multinucleated cells were positive only for vimentin, but negative for S-100 protein and Factor VIII related antigen.
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