Abstract

Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric oxide synthase (NOS) and generate substantial amounts of NO in time and dose-dependent manners. It was detectable first at 15 h after stimulation by corn silk, peaked at 24 h, and undetectable by 48 h. Induction of NOS is inhibited by pyrolidine dithiocarbamate (PDTC) and genistein, an inhibitor of nuclear factor kappa B (NF-kappaB) and tyrosine kinase, respectively, indicating that iNOS stimulated by corn silk is associated with tyrosine kinase and NF-kappaB signaling pathways. IkappaB-alpha degradation was detectible at 10 min, and the level was restored at 120 min after treatment of corn silk. Corn silk induced nuclear translocation of NF-kappaB by phosphorylation and degradation of IkappaB-alpha.

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1. Ku, Kang-Mo ; Kim, Soon-Kwon ; Kang, Young-Hwa 2009. "Antioxidant Activity and Functional Components of Corn Silk(Zea mays L.)" 韓國資源植物學會誌 = Korean journal of plant resources, 22(4): 323~329  원문보기 상세보기
2. Kim, Sun-Lim ; Kim, Mi-Jung ; Lee, Yu-Young ; Jung, Gun-Ho ; Son, Beom-Young ; Lee, Jin-Seok ; Kwon, Young-Up ; Park, Yong-Il 2014. "Isolation and Identification of Flavonoids from Corn Silk" Korean journal of crop science = 韓國作物學會誌, 59(4): 435~444  원문보기 상세보기