Allopurinol hypersensitivity syndrome typically occurs in persons with preexisting renal failure, weeks to months after allopurinol is begun, the patient develops a generalized rash that often evolves to exfoliative erythroderma. Associated with the dermatitis is fever, leukocytosis, hepatitis, typically worsening of renal function. Two patients developed erythematous skin rash one month and 15 days, respectively, after allopurinol therapy. They were treated with high dose prednisolone for three weeks, but one patient died to pneumonia and sepsis, and the other patient improved and followed up.
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