$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma 원문보기

Journal of Korean medical science : JKMS, v.20 no.2 = no.102, 2005년, pp.236 - 241  

Hong, Su Hyung (Department of Dental Microbiology, Kyungpook National University School of Dentistry, Daegu, Korea.) ,  Kim, Ho Gak (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.) ,  Chung, Woon Bok (Department of Dental Microbiology, Kyungpook National University School of Dentistry, Daegu, Korea.) ,  Kim, Eun Young (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.) ,  Lee, Jong Young (Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.) ,  Yoon, Sang Mo (Department of Therapeutic Radiology and Oncology, Yeungnam University College of Medicine, Daegu, Korea.) ,  Kwon, Joong Goo (Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.) ,  Sohn, Yoon Kyung (Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.) ,  Kwak, Eun Kyung (Department of Pathology, Kyungpook National University School of Dentistry, Daegu, Korea.) ,  Kim, Jung Wan (Department of Dental Microbiology, Kyungpook National University School of Dentistry, Daegu, Korea.)

Abstract AI-Helper 아이콘AI-Helper

The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair such as hMLH1, MGMT, and GSTP1, and a gastric cancer-specifically methylated DNA fragment, MINT 25 in gastric c...

주제어

참고문헌 (32)

  1. 1 Bird AP CpG-rich islands and the function of DNA methylation Nature 1986 321 209 213 2423876 

  2. 2 Esteller M Corn PG Baylin SB Herman JG A gene hypermethylation profile of human cancer Cancer Res 2001 61 3225 3229 11309270 

  3. 3 To KF Leung WK Lee TL Yu J Tong JH Chan MW Ng EK Chung SC Sung JJ Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer Int J Cancer 2002 102 623 628 12448005 

  4. 4 Belinsky SA Nikula KJ Palmisano WA Michels R Saccomanno G Gabrielson E Baylin SB Herman JG Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proc Natl Acad Sci USA 1998 95 11891 11896 9751761 

  5. 5 Toyota M Ahuja N Suzuki H Itoh F Ohe-Toyota M Imai K Baylin SB Issa JP Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype Cancer Res 1999 59 5438 5442 10554013 

  6. 6 Oue N Oshimo Y Nakayama H Ito R Yoshida K Matsusaki K Yasui W DNA methylation of multiple genes in gastric carcinoma: Association with histological type and CpG island methylator phenotype Cancer Sci 2003 94 901 905 14556664 

  7. 7 Sambrook J Fritsch EF Maniatis T Sambrook J Fritsch EF Maniatis T Isolation of high-molecular-weight DNA from mammalian cells Molecular cloning: A laboratory manual 1989 2nd eds Cold spring harbor, New York Cold Spring Harbor Lab. Press 9.16 9.22 

  8. 8 Wang RY Gehrke CW Ehrlich M Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues Nucleic Acids Res 1980 8 4777 4790 7443525 

  9. 9 Olek A Oswald J Walter J A modified and improved method for bisulphite based cytosine methylation analysis Nucleic Acids Res 1996 24 5064 5066 9016686 

  10. 10 Esteller M Hamilton SR Burger PC Baylin SB Herman JG Inactivation of the DNA repair gene O 6 -methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res 1999 59 793 797 10029064 

  11. 11 Wheeler JM Beck NE Kim HC Tomlinson IP Mortensen NJ Bodmer WF Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1 Proc Natl Acad Sci USA 1999 96 10296 10301 10468602 

  12. 12 Esteller M Levine R Baylin SB Ellenson LH Herman JG MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas Oncogene 1998 17 2413 2417 9811473 

  13. 13 Esteller M Catasus L Matias-Guiu X Mutter GL Prat J Baylin SB Herman JG hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis Am J Pathol 1999 155 1767 1772 10550333 

  14. 14 Fleisher AS Esteller M Wang S Tamura G Suzuki H Yin J Zou TT Abraham JM Kong D Smolinski KN Shi YQ Rhyu MG Powell SM James SP Wilson KT Herman JG Meltzer SJ Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability Cancer Res 1999 59 1090 1095 10070967 

  15. 15 Oue N Shigeishi H Kuniyasu H Yokozaki H Kuraoka K Ito R Yasui W Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma Int J Cancer 2001 93 805 809 11519041 

  16. 16 Pickett CB Lu AY Glutathione S-transferases: gene structure, regulation, and biological function Annu Rev Biochem 1989 58 743 764 2673020 

  17. 17 Tsuchida S Sato K Glutathione transferases and cancer Crit Rev Biochem Mol Biol 1992 27 337 384 1521461 

  18. 18 Lee WH Morton RA Epstein JI Brooks JD Campbell PA Bova GS Hsieh WS Isaacs WB Nelson WG Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis Proc Natl Acad Sci USA 1994 91 11733 11737 7972132 

  19. 19 Toyota M Ahuja N Ohe-Toyota M Herman JG Baylin SB Issa JP CpG island methylator phenotype in colorectal cancer Proc Natl Acad Sci USA 1999 96 8681 8686 10411935 

  20. 20 Carvalho B Pinto M Cirnes L Oliveira C Machado JC Suriano G Hamelin R Carneiro F Seruca R Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas Eur J Cancer 2003 39 1222 1227 12763209 

  21. 21 Nakajima T Akiyama Y Shiraishi J Arai T Yanagisawa Y Ara M Fukuda Y Sawabe M Saitoh K Kamiyama R Hirokawa K Yuasa Y Age-related hypermethylation of the hMLH1 promoter in gastric cancers Int J Cancer 2001 94 208 211 11668499 

  22. 22 Baylin SB Herman JG Graff JR Vertino PM Issa JP Alterations in DNA methylation: a fundamental aspect of neoplasia Adv Cancer Res 1998 72 141 196 9338076 

  23. 23 Ahuja N Li Q Mohan AL Baylin SB Issa JP Aging and DNA methylation in colorectal mucosa and cancer Cancer Res 1998 58 5489 5494 9850084 

  24. 24 Pulling LC Divine KK Klinge DM Gilliland FD Kang T Schwartz AG Bocklage TJ Belinsky SA Promoter hypermethylation of the O 6 -methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression Cancer Res 2003 63 4842 4848 12941804 

  25. 25 Hasegawa M Nelson HH Peters E Ringstrom E Posner M Kelsey KT Patterns of gene promoter methylation in squamous cell cancer of the head and neck Oncogene 2002 21 4231 4236 12082610 

  26. 26 Bai H Gu L Zhou J Deng D p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N-nitro-N-nitrosoguanidine Mutat Res 2003 535 73 78 12547284 

  27. 27 Musulen E Moreno V Reyes G Sancho FJ Peinado MA Esteller M Herman JG Combalia N Rey M Capella G Standardized approach for microsatellite instability detection in gastric carcinomas Hum Pathol 2004 35 335 342 15017590 

  28. 28 Ottini L Palli D Falchetti M D'Amico C Amorosi A Saieva C Calzolari A Cimoli F Tatarelli C De Marchis L Masala G Mariani-Costantini R Cama A Microsatellite instability in gastric cancer is associated with tumor location and family history in a high-risk population from Tuscany Cancer Res 1997 57 4523 4529 9377564 

  29. 29 Wu MS Lee CW Shun CT Wang HP Lee WJ Sheu JC Lin JT Clinicopathological significance of altered loci of replication error and microsatellite instability-associated mutations in gastric cancer Cancer Res 1998 58 1494 1497 9537253 

  30. 30 Yamamoto H Perez-Piteira J Yoshida T Terada M Itoh F Imai K Perucho M Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features Gastroenterology 1999 116 1348 1357 10348818 

  31. 31 Kim H Kim YH Kim SE Kim NG Noh SH Kim H Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability J Pathol 2003 200 23 31 12692837 

  32. 32 Oue N Sentani K Yokozaki H Kitadai Y Ito R Yasui W Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa Pathobiology 2001 69 143 149 11872960 

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로