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Promoter Methylation of E-cadherin in Hepatocellular Carcinomas and Dysplastic Nodules

Journal of Korean medical science : JKMS v.20 no.2 = no.102 , 2005년, pp.242 - 247  
Kwon, Ghee Young (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) ;  Yoo, Byung Chul ( Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) ;  Koh, Kwang Cheol ( Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) ;  Cho, Jae Won ( Department of General Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) ;  Park, Won Sang ( Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ) ;  Park, Cheol Keun ( Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.)
Abstract

In order to clarify the significance of E-cadherin methylation in multistep hepatocarcinogenesis, we examined the methylation status of the E-cadherin promoter region, using methylation-specific polymerase chain reaction in 64 hepatocellular carcinomas (HCCs) and 13 dysplastic nodules (DNs), and correlated these results with E-cadherin protein expression and clinicopathologic factors of HCCs. Promoter methylation was detected in 1 of 13 (7.7%) DNs, in 5 of 13 (38.5%) Edmondson and Steiner grade I HCCs, and in 27 of 51 (52.9%) grade II or III HCCs, and a significant correlation was observed between the methylation status and the stepwise progression of hepatocarcinogenesis (p=0.004). Reduced E-cadherin immunoreactivity was found in 18 of 64 (28%) HCCs, but in none of DNs. E-cadherin methylation status in HCCs was significantly correlated with microvascular invasion (p=0.02) and tumor recurrence (p=0.04), but not with reduced E-cadherin immunoreactivity. The Kaplan-Meier method showed that methylation status did not have a significant influence on the recurrence-free survival of HCC patients (p=0.15). Our results indicate that methylation of the E-cadherin promoter region is a frequent event in HCC, which may play an important role in the stepwise progression of hepatocarcinogenesis. And the promoter methylation of E-cadherin in HCC was found to be significantly correlated with microvascular invasion and recurrence.

주제어

#Carcinoma, Hepatocellular   #Dysplastic Nodule   #Cadherins   #DNA Methylation  

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