[논문]Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma

Cho, Dae Sung; Joo, Hee Jae; Oh, Dong Keun; Kang, Ji Hun; Kim, Young Soo; Lee, Kyi Beom; Kim, Se Joong

doi:10.3349/ymj.2005.46.1.133

Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma 원문보기

Yonsei medical journal, v.46 no.1, 2005년, pp.133 - 140

Cho, Dae Sung (Department of Urology, Ajou University School of Medicine, Suwon, Korea.) , Joo, Hee Jae (Department of Pathology, Ajou University School of Medicine, Suwon, Korea.) , Oh, Dong Keun (Department of Urology, Ajou University School of Medicine, Suwon, Korea.) , Kang, Ji Hun (Department of Urology, Ajou University School of Medicine, Suwon, Korea.) , Kim, Young Soo (Department of Urology, Ajou University School of Medicine, Suwon, Korea.) , Lee, Kyi Beom (Department of Pathology, Ajou University School of Medicine, Suwon, Korea.) , Kim, Se Joong (Department of Urology, Ajou University School of Medicine, Suwon, Korea.)

Abstract ▼ AI-Helper

The aim of this study was to investigate the relationship of cyclooxygenase (COX)-2 and p53 expression with prognosis in patients with conventional renal cell carcinoma (RCC). Formalin-fixed, paraffin-embedded tissue sections of conventional RCC from 92 patients, who had undergone radical nephrectomy, were examined for COX-2 and p53 expression by immunohistochemistry and compared with clinicopathological variables. The COX-2 expression significantly correlated only with tumor size (p=0.049), whereas the p53 expression profoundly correlated with the TNM stage (p=0.024), M stage (p=0.001), and metastasis (synchronous or metachronous; p=0.004). The COX-2 overexpression did not significantly associate with p53 positivity (p=0.821). The survival rate of patients correlated with the p53 expression (p<0.0001) but not with the COX-2 expression (p=0.7506). Multivariate analyses indicated that tumor size, M stage, and p53 expression were independent prognostic factors for cancer-specific survival. The COX-2 expression was not an independent factor. These results show that the increased expression of p53 was associated with metastasis and a worse prognosis in conventional RCC, which suggests that p53 might have played an important role in the progression of conventional RCC. The increased expression of COX-2 was associated only with tumor size, but may not be an important prognostic factor in conventional RCC. No association was observed between COX-2 overexpression and p53 positivity in conventional RCC.

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참고문헌 (29)

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Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma 원문보기

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