[논문]Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer

Song, Hong Suk; Kim, In Ho; Sohn, Soo Sang; Kwon, Kun Young; Lee, Won Sik

doi:10.3904/kjim.2005.20.1.1

Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer 원문보기

The Korean journal of internal medicine : KJIM, v.20 no.1, 2005년, pp.1 - 7

Song, Hong Suk (Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.) , Kim, In Ho (Department of General Surgery, Keimyung University School of Medicine, Daegu, Korea.) , Sohn, Soo Sang (Department of General Surgery, Keimyung University School of Medicine, Daegu, Korea.) , Kwon, Kun Young (Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.) , Lee, Won Sik (Department of Internal Medicine, Fatima Hospital, Daegu, Korea.)

Abstract ▼ AI-Helper

BackgroundThe aim of this study was to determine the prognostic significance of the expression of p53 and retinoblastoma (Rb) gene products in cases of curatively resected gastric adenocarcinoma, by immunohistochemical analysis.MethodsBetween January 1996 and December 2001, 736 curatively resected gastric cancer patients underwent immunohistochemical staining for p53 or Rb proteins (pRb), and we retrospectively analyzed the correlation of our results with the clinical outcomes of these cases.ResultsHigh levels of expression of p53 (>25% p53-positive cells) and Rb (>50% Rb-positive cells) proteins were detected in 40.1% and 43.7% of cases, respectively. Tubular type was found to frequently exhibit higher levels of p53 expression (high expression in 44.2%) than signet ring cell type (high expression in 26.0%) (p=0.042). The incidence of vascular invasion was lower in the high pRb expressors (43.2%) than in the pRb low expressors (56.8%), but this was not a statistically significant discrepancy (p=0.063). Preoperative CEA levels were found to be low in high pRb expressors: initial CEA level in the high pRb expressors was 2.31±3.30 ng/mL, and was 5.18±24.80 ng/mL in the low pRb expressors (p=0.033). Tumor depth and node metastasis were both independent of the levels of expression of p53 and Rb proteins. The seven-year overall survival rate and relapse-free survival rates of patients were 87.2% and 75.7%, respectively. Multivariate Cox regression analysis indicated that tumor stage, tumor size, patient age and pRb expression were the significant prognostic factors with regard to overall survival, and tumor stage and age were both significant factors with regard to relapse-free survival.ConclusionImmunohistochemical staining of retinoblastoma gene products was an independent prognostic factor for the prediction of overall survival in curatively resected gastric cancer patients.

주제어

참고문헌 (28)

1 Mercer WE Shields MT Lin D Appella E Ullrich SJ Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating cell nuclear antigen expression Proc Natl Acad Sci U S A 1991 88 1958 1962 1705714

상세보기
2 Fields S Jang SK Presence of a potent transcription activating sequence in he p53 protein Science 1990 249 1046 1049 2144363
3 Sachs L Lotem J Control of programmed cell death in normal and leukemic cells: new implications for therapy Blood 1993 82 15 21 8324219

상세보기
4 Wyllie AH Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview Cancer Metastasis Rev 1992 11 95 103 1394797

상세보기
5 Wiman KG The retinoblastoma gene: role in cell cycle control and cell differentiation FASEB J 1993 7 841 845 8393817

상세보기
6 Bookstein R Lee WH Molecular genetics of the retinoblastoma suppressor gene Crit Rev Oncog 1991 2 211 227 1888791

상세보기
7 Buchkovich K Duffy LA Harlow E The retinoblastoma protein is phosphorylated during specific phases of the cell cycle Cell 1989 58 1097 1105 2673543

상세보기
8 Weinberg RA The retinoblastoma protein and cell cycle control Cell 1995 81 323 330 7736585

상세보기
9 Ogawa M Maeda K Chung YS Onoda N Kato Y Nakata B Sowa M Correlation between expression of RB protein and prognosis of gastric cancer Gan To Kagaku Ryoho 1996 23 Suppl 2 148 150 8678558
10 Dong Y Walsh MD McGuckin MA Cummings MC Gabrielli BG Wright GR Hurst T Khoo SK Parsons PG Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer Int J Cancer 1997 74 407 415 9291430

상세보기
11 Maeda K Kang SM Onoda N Ogawa M Sawada T Nakata B Kato Y Chung YS Sowa M Expression of p53 and vascular endothelial growth factor associated with tumor angiogenesis and prognosis in gastric cancer Oncology 1998 55 594 599 9778629
12 Finlay CA Hinds PW Tan TH Eliyahu D Oren M Levine AJ Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life Mol Cell Biol 1988 8 531 539 2832726

상세보기
13 Uchino S Noguchi M Ochiai A Saito T Kobayashi M Hirohashi S p53 mutation in gastric cancer: a genetic model for carcinogenesisis common to gastric and colorectal cancer Int J Cancer 1993 54 759 764 8392033

상세보기
14 Maehara Y Tomoda M Hasuda S Kabashima A Tokunaga E Kakeji Y Sugimachi K Prognostic value of p53 protein expression for patients with gastric cancer: a multivariate analysis Br J Cancer 1999 79 1255 1261 10098768

상세보기
15 Gomyo Y Ikeda M Osaki M Tatebe S Tsujitani S Ikeguchi M Kaibara N Ito H Expression of p21(waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma Cancer 1997 79 2067 2072 9179052
16 Shun CT Wu MS Lin JT Chen SY Wang HP Lee WJ Wang TH Chuang SM Relationship of p53 and c-erbB-2 expression to histological features: Helicobacter pylori infection and prognosis in gastric cancer Hepatogastroenterology 1997 44 604 609 9164544
17 Ichiyoshi Y Oiwa H Tomisaki S Sakaguchi Y Ohno S Maehara Y Sugimachi K Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer Hepatogastroenterology 1997 44 546 553 9164535

상세보기
18 Lim BH Soong R Grieu F Robbins PD House AK Iacopetta BJ p53 accumulation and mutation are prognostic indicators of poor survival in human gastric carcinoma Int J Cancer 1996 69 200 204 8682588

상세보기
19 Friend SH Bernards R Rogelj S Weinberg RA Rapaport JM Albert DM Dryja TP A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma Nature 1986 323 643 646 2877398

상세보기
20 Kastan MB Onyekwere O Sidransky D Vogelstein B Craig RW Participation of p53 protein in the cellular response to DNA damage Cancer Res 1991 51 6304 6311 1933891

상세보기
21 Pedley J Ablett EM Pettit A Meyer J Donn IS Sturm RA Parsons PG Inhibition of retinoblastoma protein translation by UVB in human melanocytic cells and reduced cell cycle arrest following repeated irradiation Oncogene 1996 13 1335 1342 8808708

상세보기
22 Yokota J Yamamoto T Miyajima N Toyoshima K Nomura N Sakamoto H Yoshida T Terada M Sugimura T Genetic alterations of the c-erb2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue Oncogene 1988 2 283 287 3281095
23 Gabbert HE Muller W Schneiders A Meier S Hommel G The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma Cancer 1995 76 720 726 8625172
24 Santoro E Carboni M Catarci M Carlini M Carboni F Zupi G Vecchione A D'Agnano I Giannarelli D Santoro R Farofalo A DNA ploidy, proliferative index and EGF-R status in 130 cases of resected gastric cancer: a multivariate analysis Hepatogastroenterology 1997 44 826 837 9222700

상세보기
25 Song H Do Y Kim I Sohn S Lee W Prognostic significance of age in curatively resected gastric cancer Proc Am Soc Clin Oncol 2004 23 344
26 Guadagni S Reed PI Johnson BJ de Bernardinis G Catarci M Valenti M di Orio F Carboni M Early gastric cancer: follow-up after gastrectomy in 159 patients Br J Surg 1993 80 325 328 8472141

상세보기
27 Hurlimann J Saraga EP Expression of p53 protein in gastric carcinomas: association with histologic type and prognosis Am J Surg Pathol 1994 18 1247 1253 7977948

상세보기
28 Xu HJ Hu SX Cagle PT Moore GE Benedict WF Absence of retinoblastoma protein expression in primary non-small cell lung carcinoma Cancer Res 1991 51 2735 2739 1850661

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (28)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트