$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

A Comparison of Expressions of MMP-3, MMP-7, TIMP-1 and Apoptosis in Keratoacanthoma and Squamous Cell Carcinoma

Abstract

BACKGROUND: Keratoacanthoma (KA) is a unique neoplasm, usually accompanied by rapid growth and regression, and the histologic findings resemble those of squamous cell carcinoma (SCC). Histologic differentiation of KA and SCC is challenging, therefore a number of studies have been carried out to differentiate these two entities using immunohistochemical staining. However, the results were inconsistent. There is now a debate as to whether KA is a benign tumor or a less aggressive variant of SCC. OBJECTIVE: The purpose of this study was to examine the expression patterns of MMP-3, MMP-7, TIMP-1, the apoptotic index in KA and SCC, and the usefulness of immunohistochemical staining in differentiating these two entities. METHODS: Formalin-fixed, paraffin-embedded biopsy specimens obtained from 12 KA and 16 SCC patients were investigated for the expressions of MMP-3, MMP-7 and TIMP-1 using an immnohistochemical staining method and apoptotic index by TUNEL method. RESULTS: 1. The expression of MMP-3 in mass was slightly higher in the SCC group (3.4+/-1.03) than the KA group (2.7+/-1.50). The expression of MMP-3 on the stroma was significantly higher for the SCC group (2.6+/-0.96) than the KA group (1.5+/-1.24) (p<0.05). 2. The expression of MMP-7 was detected only in a single case within the SCC group. 3. The expression of TIMP-1 was detected in two cases within the KA group. 4. The apoptotic index (%) was significantly higher in the SCC group (57.3+/- 32.15) than the KA group (36.1+/-21.78) (p<0.05). CONCLUSION: The immunohistochemical staining method of MMP-3, MMP-7 and TIMP-1 is not sensitive enough to differentiate between the two diseases. However, it has been suggested that MMP-3 of the stroma is involved in invasion of SCC more than MMP-3 of the mass, that MMP-7 plays a role in the early stage of SCC, and that TIMP-1 inhibits the action of MMPs and invasion in KA. We suggest that KA can be regarded as a clinically benign end of the SCC disease spectrum. The apoptotic index was higher in the SCC group than the KA group, implying that SCC has greater invasive ability due to a newly-selected, mutated, neoplastic cellular clone that has more aggressive biological behavior.

참고문헌 (0)

  1. 이 논문의 참고문헌 없음

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • 원문 PDF 정보가 존재하지 않습니다.

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일