Propylthiouracil (PTU) as a drug for hyperthyroidism is known to be associated with drug-induced lupus erythematosus (LE) and antineutrophil cytoplasmic antibody (ANCA)-positive vascultis. A 29-year-old woman who had been receiving PTU for 12 months developed spiking fever, arthralgia and multiple purpuric skin lesions. Perinuclear ANCA (p-ANCA) with antimyeloperoxidase activity, antinuclear antibody and antihistone antibody were positive. Her condition improved after the withdrawal of PTU. The pertinent evaluation for this case established PTU-induced LE accompanied by ANCA-positive vasculitis. Although PTU-induced LE or ANCA-positive hypersensitivity vasculitis by PTU have been frequently reported in the literature, it is extremely rare that these two diseases have occurred simultaneously due to PTU, as in this case.
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