There may be some exacerbating factors which aggravate skin lesions of pemphigus foliaceus, including exposure to sun and/or heat. However, the degree of aggravation induced by these factors varies in individuals. We examined possible aggravating factors of skin lesions in a 47-years-old woman with pemphigus foliaceus who had managed her disease with topical and/or sublesional use of corticosteroids for 20 years. The lesion- provoking or exacerbating factors recognized in the patient were sleeplessness/fatigue, emotional stress, menstruation, mechanical trauma, external heat and alcohol.
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