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논문 상세정보

Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets

Abstract

Ultraviolet B (UVB) irradiation of skin induces an acute inflammation. Cyclooxygenase-2 (COX-2) protein plays key roles in acute inflammation in UVB-irradiated keratinocyte cell line HaCaT. Recently, curcumin has been regarded as a promising anti-inflammatory agent due to its ability to inhibit COX-2 expression. However, it remains largely unknown whether curcumin inhibits the UVB-induced COX-2 expression in HaCaT cells. This study was undertaken to clarify the effect of curcumin on the expression of COX-2 in UVB- irradiated HaCaT cells and further determined the molecular mechanisms associated with this process. In this study, we have found that the expression of COX-2 mRNA and protein were up-regulated in UVB-irradiated HaCaT cells in a dose- and time-dependent manner. Interestingly, treatment with curcumin strongly inhibited COX-2 mRNA and protein expressions in UVB-irradiated HaCaT cells. Notably, there was effective inhibition by curcumin on UVB-induced activations of p38 MAPK and JNK in HaCaT cells. The DNA binding activity of AP-1 transcription factor was also markedly decreased with curcumin treatment in UVB-irradiated HaCaT cells. These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells. We propose that curcumin may be applied as an effective and novel sunscreen drug for the protection of photoinflammation.

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이 논문을 인용한 문헌 (8)

  1. 2006. "" Food science and biotechnology, 15(3): 329~338 
  2. Kim, Tae-Hwan ; Jin, Cheng-Yun ; Park, Sang-Eun ; Kim, Won-Il ; Park, Dong-Il ; Kim, Gi-Young ; Kim, Nam-Deuk ; Hong, Sang-Hoon ; Choi, Yung-Hyun 2008. "Euphorbiae Humifusae Inhibits Egr-1, $NF{-\kappa}B$ and COX-2 Activity Stimulated by Phorbol 12-myristate-13-acetate" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 22(2): 415~421 
  3. 2008. "" Nutrition research and practice, 2(2): 55~61 
  4. 2010. "" Journal of medicinal food, 13(3): 495~502 
  5. 2011. "" Experimental & molecular medicine : EMM, 43(6): 323~333 
  6. Kim, Eun-Seop ; Yoo, Dong-Youl 2011. "Protective Effect of Processed Saengmaek-san(SM) on Cell Damage in UV-exposed HaCaT Cell" 大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, 24(2): 33~51 
  7. Lee, Seung-Ah ; Yoo, Dong-Youl 2011. "Protective Effect of Polygonum Multiflorum on Cell Damage in UVB-irradiated HaCaT Keratinocytes" 大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, 24(4): 31~49 
  8. 2013. "" BMB reports, 46(8): 410~415 

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