Multicentric reticulohistiocytosis is a rare systemic disorder of unknown ethiology, characterized by development of cutaneous papulonodular lesions, and destructive arthritis. Most patients with this condition have been Caucasian. There have only been a few case reports in Korea. However there appears no racial difference in prevalence. We herein report a case of multicentric reticulohistiocytosis in a 47-year-old female, who presented with papulonodules on both hands and had symptoms of a rapidly progressive arthritis. During a trial with methotrexate, cyclosporin, prednisone and NSAID, the patient dropped out of follow-up treatment at the 2nd month, showing no improvement of the condition.
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