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Simvastatin Decreases IL-6 and IL-8 Production in Epithelial Cells 원문보기

Journal of dental research, v.85 no.6, 2006년, pp.520 - 523  

Sakoda, K. (Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan) ,  Yamamoto, M. (Department of Periodontology, Showa University Dental School, Tokyo, Japan) ,  Negishi, Y. (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Liao, J. K. (Vascular Medicine Unit, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA) ,  Node, K. (Department of Cardiovascular & Renal Medicine, Saga University Faculty of Medicine, Saga, Japan) ,  Izumi, Y. (Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan)

Abstract AI-Helper 아이콘AI-Helper

Many cardiovascular studies have suggested that 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitors (statins) have anti-inflammatory effects independent of cholesterol lowering. As a chronic inflammatory disease, periodontitis shares some mechanisms with atherosclerosis. Since oral epithelia...

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참고문헌 (16)

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  2. Blanco-Colio, Luis Miguel, Tuñón, José, Martín-Ventura, Jose Luis, Egido, Jesús. Anti-inflammatory and immunomodulatory effects of statins. Kidney international, vol.63, no.1, 12-23.

  3. D'Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D., Tonetti, M. S.. Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers. Journal of dental research, vol.83, no.2, 156-160.

  4. Etienne-Manneville, Sandrine, Hall, Alan. Rho GTPases in cell biology. Nature, vol.420, no.6916, 629-635.

  5. Georganas, Constantinos, Liu, Hongtao, Perlman, Harris, Hoffmann, Alexander, Thimmapaya, Bayar, Pope, Richard M.. Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun. The journal of immunology : official journal of the American Association of Immunologists, vol.165, no.12, 7199-7206.

  6. Jefferies, Caroline A., O'Neill, Luke A.J.. Rac1 Regulates Interleukin 1-induced Nuclear Factor κB Activation in an Inhibitory Protein κBα-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression. The Journal of biological chemistry, vol.275, no.5, 3114-3120.

  7. Jefferies, Caroline, Bowie, Andrew, Brady, Gareth, Cooke, Emma-Louise, Li, Xiaoxia, O'Neill, Luke A. J.. Transactivation by the p65 Subunit of NF-κB in Response to Interleukin-1 (IL-1) Involves MyD88, IL-1 Receptor-Associated Kinase 1, TRAF-6, and Rac1. Molecular and cellular biology, vol.21, no.14, 4544-4552.

  8. O'Driscoll, Gerard, Green, Danny, Taylor, Roger R.. Simvastatin, an HMG-Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month. Circulation, vol.95, no.5, 1126-1131.

  9. Pohl A, Pohl C, Krause S, Gangler P, Losche W (1995). Hyperlipidemia, atherosclerosis, and oral inflammatory diseases. Acta Angiologica 1:133-137. 

  10. Rauch, U., Osende, J.I., Chesebro, J.H., Fuster, V., Vorchheimer, D.A., Harris, K., Harris, P., Sandler, D.A., Fallon, J.T., Jayaraman, S., Badimon, J.J.. Statins and cardiovascular diseases: the multiple effects of lipid-lowering therapy by statins. Atherosclerosis, vol.153, no.1, 181-189.

  11. Stashenko, P., Fujiyoshi, P., Obernesser, M. S., Prostak, L., Haffajee, A. D., Socransky, S. S.. Levels of interleukin 1β in tissue from sites of active periodontal disease. Journal of clinical periodontology, vol.18, no.7, 548-554.

  12. Suchett-Kaye, George, Morrier, Jean-Jacques, Barsotti, Odile. Interactions Between Non-Immune Host Cells and the Immune System During Periodontal Disease: Role of the Gingival Keratinocyte. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, vol.9, no.3, 292-305.

  13. Tada, H., Sugawara, S., Nemoto, E., Imamura, T., Potempa, J., Travis, J., Shimauchi, H., Takada, H.. Proteolysis of ICAM-1 on Human Oral Epithelial Cells by Gingipains. Journal of dental research, vol.82, no.10, 796-801.

  14. Takemoto, Masao, Liao, James K.. Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors. Arteriosclerosis, thrombosis, and vascular biology, vol.21, no.11, 1712-1719.

  15. Takemoto, Masao, Node, Koichi, Nakagami, Hironori, Liao, Yulin, Grimm, Michael, Takemoto, Yaeko, Kitakaze, Masafumi, Liao, James K.. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. The Journal of clinical investigation, vol.108, no.10, 1429-1437.

  16. Yang, Haitao, Feng, Yan, Luan, Yiwen. Determination of Simvastatin in human plasma by liquid chromatography–mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol.785, no.2, 369-375.

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