[논문]Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay

Long, S.R.; Carey, R.A.; Crofoot, K.M.; Proteau, P.J.; Filtz, T.M.

doi:10.1016/j.phymed.2006.01.005

Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay

Phytomedicine : international journal of phytotherapy and phytopharmacology, v.13 no.9/10, 2006년, pp.643 - 650

Long, S.R. (Oregon State University College of Pharmacy, Corvallis, OR, USA) , Carey, R.A. (Oregon State University College of Pharmacy, Corvallis, OR, USA) , Crofoot, K.M. (Oregon State University College of Pharmacy, Corvallis, OR, USA) , Proteau, P.J. (Oregon State University College of Pharmacy, Corvallis, OR, USA) , Filtz, T.M. (Corresponding author. Tel.: +15417375802)

Abstract ▼ AI-Helper

AbstractExtracts of hawthorn (Crataegus oxycantha) have become popular herbal supplements for their well-recognized cardiotonic effects. Many commercial preparations have been used successfully in the treatment of congestive heart failure, although the active principles within these extracts have yet to be conclusively identified. Several hawthorn preparations were studied and found to have negative chronotropic effects in a cultured neonatal murine cardiomyocyte assay using unpaced cells. As compared to conventional cardiac drugs (i.e., epinephrine, milrinone, ouabain, or propranolol), hawthorn extract has a unique activity profile. Hawthorn extract appears to be anti-arrhythmic and capable of inducing rhythmicity in quiescent cardiomyocytes. Hawthorn extract does not cause β-adrenergic receptor blockade at concentrations which cause negative chronotropic effects. Commercial hawthorn preparations, extracts prepared from dried leaves and those made from dried berries have similar chronotropic activities. When crude extracts are separated using size-exclusion chromatography, several fractions retain multiple cardiac activities. Assays with chromatographic fractions reveal that multiple dissimilar cardioactive components may exist within the extract, making the identification of individual active constituents more challenging.

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참고문헌 (20)

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표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay

Abstract ▼ AI-Helper

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