[논문]Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments

Iizuka, Y.; Endo, Y.; Misawa, Y.; Misaka, E.

doi:10.1007/bf01967623

Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments

Agents and actions, v.11 no.3, 1981년, pp.254 - 259

Iizuka, Y. , Endo, Y. , Misawa, Y. , Misaka, E.

Abstract ▼ AI-Helper

AbstractSimple laboratory methods for quantitating the topical anti-inflammatory activity of steroidal ointments are described. One is of croton oil ear edema in rats and the other is a new method using homologous passive cutaneous anaphylaxis (PCA) in rats. In order to avoid problems such as the animals' licking and/or rubbing the ointment at the applied sites, which might result in oral uptake, each rat was housed individually and fitted with a plastic collar in the corton oil experiment. The sites of ointment application in the PCA experiment were covered with adhesive plaster.Optimal experimental conditions were as follows. In the former method, ointments were applied to the inside surface of the ear 5 min after the irritant treatment and anti-edematous activity was determined after 6 h. In the latter, ointments were applied 3 h before the antigenic challenge to the dorsal area of animals which had been passively sensitized by anti-serum, and inhibition of the increased permeability was determined 45 min after the challenge.These methods were found to be reliable with respect to sensitivity and reproducibility of data. Ointments of halcinonide, betamethasone-17-valerate, hydrocortisone-17-butyrate, fluocinonide, flumethasone-21-pivalate and beclomethasone-17,21-dipropionate were evaluated by these methods.

참고문헌 (15)

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표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments

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