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NTIS 바로가기Journal of separation science, v.31 no.6/7, 2008년, pp.921 - 925
Zhou, Wei (Department of Biosynthetic Drug, School of Pharmacy, Fudan University, Shanghai, China. Fax: +86-21-64225149) , Li, Jiyang (Department of Biosynthetic Drug, School of Pharmacy, Fudan University, Shanghai, China. Fax: +86-21-64225149) , Li, Xinwei (Department of Biosynthetic Drug, School of Pharmacy, Fudan University, Shanghai, China. Fax: +86-21-64225149) , Yan, Qin (Department of Biosynthetic Drug, School of Pharmacy, Fudan University, Shanghai, China. Fax: +86-21-64225149) , Zhou, Pei (Department of Biosynthetic Drug, School of Pharmacy, Fudan University, Shanghai, China. Fax: +86-21-64225149)
A simple and rapid gradient RP-HPLC method for simultaneous separation and determination of related ginsenosides during the process of biotransformation of ginsenoside Rb1 has been developed. As many as four process ginsenosides have been separated and identified on an Eclipse XDB C18 column (4.6 mm...
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Akao, Teruaki, Kida, Hiroaki, Kanaoka, Matao, Hattori, Masao, Kobashi, Kyoichi. Drug Metabolism: Intestinal Bacterial Hydrolysis is Required for the Appearance of Compound K in Rat Plasma after Oral Administration of Ginsenoside Rb1 from Panax ginseng. Journal of pharmacy and pharmacology, vol.50, no.10, 1155-1160.
Bae, Eun-Ah, Choo, Min-Kyung, Park, Eun-Kyung, Park, Sun-Young, Shin, Ho-Young, Kim, Dong-Hyun. Metabolism of Ginsenoside Rc by Human Intestinal Bacteria and Its Related Antiallergic Activity. Biological & pharmaceutical bulletin, vol.25, no.6, 743-747.
Lee, B H, Lee, S J, Hur, J H, Lee, S, Sung, J H, Huh, J D, Moon, C K, Hui, J H. In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria.. Planta medica, vol.64, no.6, 500-503.
Hasegawa, H, Uchiyama, M. Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite.. Planta medica, vol.64, no.8, 696-700.
Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J., Saiki, I.. An Intestinal Bacterial Metabolite of Ginseng Protopanaxadiol Saponins Has the Ability to Induce Apoptosis in Tumor Cells. Biochemical and biophysical research communications, vol.246, no.3, 725-730.
Lee, Hae-Ung, Bae, Eun-Ah, Han, Myung Joo, Kim, Nam-Jae, Kim, Dong-Hyun. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver international : official journal of the International Association for the Study of the Liver, vol.25, no.5, 1069-1073.
Park, Eun-Kyung, Shin, Yong-Wook, Lee, Hae-Ung, Kim, Sung-Soo, Lee, Young-Churl, Lee, Boo-Yong, Kim, Dong-Hyun. Inhibitory Effect of Ginsenoside Rb1 and Compound K on NO and Prostaglandin E2 Biosyntheses of RAW264.7 Cells Induced by Lipopolysaccharide. Biological & pharmaceutical bulletin, vol.28, no.4, 652-656.
Hasegawa, H, Sung, J H, Benno, Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins.. Planta medica, vol.63, no.5, 436-440.
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