Objective: The purpose of this study was to investigate the effect of xylitol chewing gum containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (RecaldentTM) and xylitol tablet containing fluoride (XyliFTM) on remineralization of artificial incipient caries lesions in situ model. Methods: Seventy-five 3 x 3 mm bovine incisors were demineralized and mounted into the acrylic mandibular removable appliance. Three experimental groups were considered in this study; no treated (saliva), RecaldentTM gum, and XyliFTM tablet. Five subjects wore the appliance without any treatment, with daily melted XyliFTM tablet, or chewed RecaldentTM gum for 7 minutes 4 times in a day during 2 weeks. There was one week of wash-out period between consecutive experiments to prevent carry-over effect. Surface microhardness, scanning electron microscope (SEM), AFM and confocal laser scanning microscope (CLSM) analysis were adapted to compare the remineralizing sequences. Results: VHNs in XyliFTM tablet and RecaldentTM gum groups after remineralization were significantly increased than those of saliva group (p<0.05). In SEM, there were found some evidences of remineralization with relatively homogeneous surface pattern and granules both XyliFTM and RecaldentTM groups. The XyliFTM and RecaldentTM groups decreased the fluorescent lesion depth as compared to the saliva group by CLSM. Conclusion: These results showed that XyliFTM tablet and RecaldentTM gum also have shown effectiveness on remineralization of artificial incipient caries lesions in situ model. At all analysis, XyliFTM tablet was better to remineralizing artificial caries lesions than RecaldentTM gum.
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