Protective Effects of Cinnamomum cassia Blume in the Fibrogenesis of Activated HSC-T6 Cells and Dimethylnitrosamine-Induced Acute Liver Injury in SD Rats원문보기
LIM, Chang-Shin
(College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University)
,
KIM, Eun-Young
(College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University)
,
LEE, Hyun-Sam
(College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University)
,
SOH, Yunjo
(Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
,
SOHN, Youngjoo
(College of Oriental Medicine, Sangji University)
,
KIM, Sun Yeou
(Graduate School of East-West Medicine, Kyung Hee University)
,
SOHN, Nak-Won
(Graduate School of East-West Medicine, Kyung Hee University)
,
JUNG, Hyuk-Sang
(College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University)
,
KIM, Yoon-Bum
(College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University)
Cinnamomum cassia Blume (CC) is one of the world’s oldest natural spices, and is commonly used in traditional oriental medicine. We investigated the protective effect of ethanol extract from Cinnamomum cassia Blume (CCE) on the activation of hepatic stellate cells (HSCs). In addition, we exami...
Cinnamomum cassia Blume (CC) is one of the world’s oldest natural spices, and is commonly used in traditional oriental medicine. We investigated the protective effect of ethanol extract from Cinnamomum cassia Blume (CCE) on the activation of hepatic stellate cells (HSCs). In addition, we examined the effects of CC powder in Sprague-Dawley rats with acute liver injury induced by dimethylnitrosamine (DMN). In vitro, HSC-T6 cells exhibit an activated phenotype, as reflected in their fibroblast-like morphology. CCE significantly reduced the expression of alpha-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), transforming growth factor beta (TGF-β1), and tissue inhibitor of metalloproteinase-1 (TIMP-1). In vivo, the results were significantly protected by CC powder in the serum total protein, albumin, total-bilirubin, direct-bilirubin, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP). We suggest that CC inhibits fibrogenesis, followed by HSC-T6 cell activation and increased restoration of liver function, ultimately resulting in acute liver injury.
Cinnamomum cassia Blume (CC) is one of the world’s oldest natural spices, and is commonly used in traditional oriental medicine. We investigated the protective effect of ethanol extract from Cinnamomum cassia Blume (CCE) on the activation of hepatic stellate cells (HSCs). In addition, we examined the effects of CC powder in Sprague-Dawley rats with acute liver injury induced by dimethylnitrosamine (DMN). In vitro, HSC-T6 cells exhibit an activated phenotype, as reflected in their fibroblast-like morphology. CCE significantly reduced the expression of alpha-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), transforming growth factor beta (TGF-β1), and tissue inhibitor of metalloproteinase-1 (TIMP-1). In vivo, the results were significantly protected by CC powder in the serum total protein, albumin, total-bilirubin, direct-bilirubin, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP). We suggest that CC inhibits fibrogenesis, followed by HSC-T6 cell activation and increased restoration of liver function, ultimately resulting in acute liver injury.
10.1007/978-94-011-4932-7_22 3) Wu J, Kuncio GS, and Zern MA, “Liver Growth Repair: from Basic Science to Clinical Practice,” Chapman and Hall, London, pp. 558-576 (1998).
14) Lou ZQ and Qin B, “Species Systemization and Quality Evaluation of Commonly Used Chinese Traditional Drugs” Vol. 1, Peking University Medical Press, pp. 203-251 (1995).
Lee, Hee-Seung, Jung, Kyung Hee, Park, In-Suh, Kwon, Sung Won, Lee, Don-Haeng, Hong, Soon-Sun.
Protective Effect of Morin on Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats.
Digestive diseases and sciences,
vol.54,
no.4,
782-788.
46) Edwards DR, Leco KJ, Leco PA, Lim MS, Phillips BW, Raja J, and Sharma R, “Regulation of TIMP Gene Expression: In Tissue Inhibitors of Metalloproteinases in Development and Disease,” Lausanne, Switzerland, pp. 13-24 (2000).
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