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Abstract ▼ AI-Helper

Since simian immunodeficiency virus (SIV) was found to be origin of the human immunodeficiency virus (HIV), a major task has been to characterize the diversity of SIV strains in the wild and to assess their potential ability for trans-infection into humans. To date, more than 20 species of SIV-infec...

Since simian immunodeficiency virus (SIV) was found to be origin of the human immunodeficiency virus (HIV), a major task has been to characterize the diversity of SIV strains in the wild and to assess their potential ability for trans-infection into humans. To date, more than 20 species of SIV-infected African non-human primates have been detected. All of them are not yet identified with full-length genome and many researchers bring their attention into the detection of SIV only. Six lineages are recognized based on phylogenetic relationship with full-length genomes. Phylogenetic analysis indicated that they have very divergent strains and abnormal feature by gene recombination. Some of them have ability to trans-infection into the humans and replicate in human peripheral blood mononuclear cells (PBMC) efficiently. Therefore, they can be a potential host in the nature. We have to investigate the whole of the wild African non-human primates to detect and identify SIV lineages. To reveal the exact orgin of the SIV and their phylogenetic relationship in African non-human primates, we have to consider their behavior and living area. We will gradually understand HIV nature with the study of all SIV lineages, and recover AIDS disease with primate research in human life.

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