[논문]Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells

Pang, Bo; Shin, Dong Hoon; Park, Kyung Sun; Huh, Yun Jeong; Woo, Joohan; Zhang, Yin-Hua; Kang, Tong Mook; Lee, Ki-Young; Kim, Sung Joon

doi:10.1007/s00424-011-1039-x

Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells

Pflügers archiv : European journal of physiology, v.463 no.2, 2012년, pp.309 - 318

Pang, Bo , Shin, Dong Hoon , Park, Kyung Sun , Huh, Yun Jeong , Woo, Joohan , Zhang, Yin-Hua , Kang, Tong Mook , Lee, Ki-Young , Kim, Sung Joon

Abstract ▼ AI-Helper

Sustained increase in [Ca(2+)](c) (δ[Ca(2+)](c)) is a critical early signal from T-cell receptor (TCR/CD3). In general, Ca(2+)-release activated Ca(2+) channels (CRAC) are responsible for the Ca(2+) influx and δ[Ca(2+)](c) after TCR/CD3 stimulation. However, T cells also express Ca(2+)-permeable nonselective cation channels such as TRPM2 and TRPC. Gd(3+) is a relatively selective blocker for CRAC at micromolar concentrations. Here, Jurkat T cells were used to investigate the Gd(3+)-resistant Ca(2+) influx (δ[Ca(2+)](c,Gd)) induced by concanavalin A (ConA, 1?μg/ml), a widely used mitogenic agent for T cells, or by anti-CD3 Ab (αCD3). αCD3-induced δ[Ca(2+)](c) was partly (~60%) inhibited by 1?μM Gd(3+) while thapsigargin-induced δ[Ca(2+)] was almost completely abolished. ConA-induced δ[Ca(2+)] was mostly inhibited by 1?μM Gd(3+) during the early phase (2?min). Induction of δ[Ca(2+)](c,Gd) by αCD3 and ConA was inhibited by 2-aminoethoxydiphenyl borate (2-APB) and by N-(p-amylcinnamoyl) anthranilic acid, indicating that TRPM2 and TRPC are involved in this process. Treatment with Pyr-3, a TRPC3-specific inhibitor, potently suppressed δ[Ca(2+)](c,Gd) by αCD3 (IC(50), 0.16?μM). Patch clamp experiments demonstrated that the TRPM2 channels were activated by ConA, and the TRPC-like channels were activated by αCD3. Our present study suggests that TRPM2 and TRPC3 are activated by ConA and TCR/CD3, respectively, in Jurkat T cells and are responsible for the induction of δ[Ca(2+)](c,Gd).

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Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells

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Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells

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