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NTIS 바로가기Phytotherapy research : PTR, v.26 no.3, 2012년, pp.462 - 464
Choi, Hwa Jung (Department of Clinical Pathology, Daejeon Health Sciences College, 77‐) , Song, Jae Hyoung (3 Gayang2‐) , Kwon, Dur Han (Dong, Dong‐)
Our previous report showed that quercetin 3‐rhamnoside (Q3R) possessed antiviral activity against influenza A/WS/33 virus in vitro. The present study evaluated the effect of Q3R on influenza A/WS/33 virus infected mice. Mice orally treated with Q3R (6.25 mg/kg per dose) at 2 h before and once daily for 6 days after influenza virus infection showed significant decreases in weight loss, and decreased mortality. Lung virus titers of mice killed at 6 days after infection were about 2000 times lower than that of the placebo‐treated control mice and about two times lower than that for the oseltamivir‐treated mice. Furthermore, histological evaluation showed that administration of Q3R delayed the development and progression of pulmonary lesions. Therefore, Q3R could be an attractive lead for the development of antiviral agents against influenza virus. Copyright © 2011 John Wiley & Sons, Ltd.
Choi HJ , Kim JH , Lee CH et al. 2009a . Antiviral activity of quercetin 7‐rhamnoside against porcine epidemic diarrhea virus . Antiviral Res 81 : 77 – 81 .
Choi HJ , Song JH , Baek SH , Kwon DH . 2009b . Inhibitory effects of quercetin 3‐rhamnoside on influenza A virus replication . Eur J Pharm Sci 37 : 329 – 333 .
Colman PM . 1994 . Influenza virus neuraminidase: structure, antibodies, and inhibitors . Protein Sci 3 : 1687 – 1696 .
Droebner K , Ehrhardt C , Poetter A , Ludwig S , Planz O . 2007 . CYSTUS052, a polyphenol‐rich plant extract, exerts anti‐influenza virus activity in mice . Antiviral Res 76 : 1 – 10 .
Gubareva LV , Matrosovich MN , Brenner MK , Bethell RC , Webster RG . 1998 . Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus . J Infect Dis 178 : 1257 – 1262 .
Kaiser L , Wat C , Mills T , Mahoney P , Ward P , Hayden F . 2003 . Impact of oseltamivir treatment on influenza‐related lower respiratory tract complications and hospitalizations . Arch Int Med 163 : 1667 – 1672 .
Ölschlaäger V , Pleschka S , Fisher T et al. 2004 . Lung‐specific expression of active Raf kinase results in increased mortality of influenza A virus‐infected mice . Oncogene 23 : 6639 – 6646 .
Palamara AT , Nencioni L , Aquilano K et al. 2005 . Inhibition of influenza A virus replication by resveratrol . J Infect Dis 191 : 1719 – 1729 .
World Health Organization . 2004 . Influenza: Report by the Secretariat . World Health Assembly WHO : Geneva , A23 – A56 .
Yen HL , Monto AS , Webster RG , Govorkova EA . 2005 . Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice . J Infect Dis 192 : 665 – 672 .
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