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Association with tryptophan hydroxylase 2 gene polymorphisms and autism spectrum disorders in Korean families

Neuroscience research : the official journal of the Japan Neuroscience Society, v.73 no.4, 2012년, pp.333 - 336  

Yang, S.Y. (Department of Pharmacology, School of Medicine, Eulji University, 77, Gyeryong-ro, 771 Beon-gil, Jung-gu, Daejeon 301-746, Republic of Korea) ,  Yoo, H.J. ,  Cho, I.H. ,  Park, M. ,  Kim, S.A.

Abstract AI-Helper 아이콘AI-Helper

It was performed a family-based association study of 6 single nucleotide polymorphisms (SNPs) from the TPH2 with autism spectrum disorder (ASD) in 151 Korean trios. We found a significant association at the rs2129575 with ASD susceptibility (corrected p=0.006). Furthermore, after conduct...

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참고문헌 (28)

  1. Bioinformatics Barrett 21 2 263 2005 10.1093/bioinformatics/bth457 Haploview: analysis and visualization of LD and haplotype maps 

  2. Paediatr. Drugs Buitelaar 2 1 67 2000 10.2165/00128072-200002010-00006 Autism: current theories regarding its pathogenesis and implications for rational pharmacotherapy 

  3. Nat. Rev. Genet. Cartegni 3 4 285 2002 10.1038/nrg775 Listening to silence and understanding nonsense: exonic mutations that affect splicing 

  4. Brain Res. Cho 1139 34 2007 10.1016/j.brainres.2007.01.002 Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios 

  5. Ann. Neurol. Chugani 42 4 666 1997 10.1002/ana.410420420 Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys 

  6. Curr. Opin. Pediatr. Cook 8 4 348 1996 10.1097/00008480-199608000-00008 The serotonin system in autism 

  7. J. Autism Dev. Disord. Cook 18 4 553 1988 10.1007/BF02211873 Serotonin and measured intelligence 

  8. Am. J. Med. Genet. B: Neuropsychiatr. Genet. Coon 135B 1 42 2005 10.1002/ajmg.b.30168 Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2) 

  9. Neuropsychopharmacology Croonenberghs 22 3 275 2000 10.1016/S0893-133X(99)00131-1 Peripheral markers of serotonergic and noradrenergic function in post-pubertal, Caucasian males with autistic disorder 

  10. Nat. Rev. Genet. Folstein 2 12 943 2001 10.1038/35103559 Genetics of autism: complex aetiology for a heterogeneous disorder 

  11. Int. J. Neuropsychopharmacol. Gutknecht 10 3 309 2007 10.1017/S1461145706007437 Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation 

  12. Neuropsychopharmacology Hollander 22 2 163 2000 10.1016/S0893-133X(99)00121-9 The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder 

  13. Eur. J. Hum. Genet. Horvath 9 4 301 2001 10.1038/sj.ejhg.5200625 The family based association test method: strategies for studying general genotype-phenotype associations 

  14. Mol. Psychiatry Lim 12 5 491 2007 10.1038/sj.mp.4001923 Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons 

  15. J. Autism Dev. Disord. Lord 30 3 205 2000 10.1023/A:1005592401947 The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism 

  16. Arch. Gen. Psychiatry McDougle 53 11 993 1996 10.1001/archpsyc.1996.01830110029004 Effects of tryptophan depletion in drug-free adults with autistic disorder 

  17. J. Autism Dev. Disord. McDougle 30 5 427 2000 10.1023/A:1005551523657 Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors 

  18. Int. J. Neuropsychopharmacol. Mossner 9 4 437 2006 10.1017/S1461145705005997 Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder 

  19. Psychiatry Res. Novotny 94 2 173 2000 10.1016/S0165-1781(00)00134-7 Increased growth hormone response to sumatriptan challenge in adult autistic disorders 

  20. Biol. Psychiatry Patel 55 4 428 2004 10.1016/j.biopsych.2003.09.002 Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland 

  21. Am. J. Med. Genet. B: Neuropsychiatr. Genet. Ramoz 141B 8 861 2006 10.1002/ajmg.b.30356 Family-based association study of TPH1 and TPH2 polymorphisms in autism 

  22. BMC Med. Genet. Sacco 8 11 2007 10.1186/1471-2350-8-11 Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1 

  23. Biol. Psychiatry Scheuch 62 11 1288 2007 10.1016/j.biopsych.2007.01.015 Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons 

  24. Neurosci. Lett. Shiroiwa 472 3 194 2010 10.1016/j.neulet.2010.02.003 Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population 

  25. Neuropsychobiology Warren 34 2 72 1996 10.1159/000119295 Elevated serotonin levels in autism: association with the major histocompatibility complex 

  26. Neurosci. Res. Yoo 63 3 172 2009 10.1016/j.neures.2008.11.007 Family- and population-based association studies of monoamine oxidase A and autism spectrum disorders in Korean 

  27. Prog. Neuropsychopharmacol. Biol. Psychiatry Yoon 33 3 403 2009 10.1016/j.pnpbp.2008.12.013 TPH2-703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression 

  28. J. Mol. Neurosci. Zhang 43 3 406 2011 10.1007/s12031-010-9458-2 Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population 

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