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Design, formulation and optimization of valsartan transdermal gel containing iso-eucalyptol as novel permeation enhancer: preclinical assessment of pharmacokinetics in Wistar albino rats

Expert opinion on drug delivery, v.11 no.8, 2014년, pp.1149 - 1162  

Ahad, Abdul (King Saud University, College of Pharmacy, Department of Pharmaceutics, Riyadh 11451, Saudi Arabia) ,  Aqil, Mohd. (Faculty of Pharmacy, Jamia Hamdard University, Department of Pharmaceutics, M. B. Road, New Delhi, 110062, India) ,  Kohli, Kanchan ,  Sultana, Yasmin (Faculty of Pharmacy, Jamia Hamdard University, Department of Pharmaceutics, M. B. Road, New Delhi, 110062, India) ,  Mujeeb, Mohd.

Abstract AI-Helper 아이콘AI-Helper

Objective: The aim of this study was to develop and optimize a transdermal gel formulation of valsartan using Box-Behnken design and to evaluate it for pharmacokinetic study.Methods: The independent variables were Carbopol 940 (X1), PEG 400 (X2) and ethanol (X3) while valsartan flux (Y1), Tlag (Y2) ...

주제어

참고문헌 (60)

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