최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Indian journal of pharmaceutical sciences, v.77 no.2, 2015년, pp.127 - 134
Molina, Vivian (Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba) , Mas, R. (Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba) , Carbajal, D. (Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba)
Nonsteroidal antiinflammatory drugs include the traditional drugs and more selective COX-2 inhibitors. Traditional nonsteroidal antiinflammatory drug use is hampered by their gastrotoxicity, while COX-2-inhibitors increase the cardiovascular risk. The search of safer substances for managing inflamma...
1 Wierda RJ Geutskens SB Jukema JW Quax PH van den Elsen PJ Epigenetics in atherosclerosis and inflammation J Cell Mol Med 2010 30 1225 40 20132414
2 Alessandri AL Sousa LP Lucas CD Rossi AG Pinho V Teixeira MM Resolution of inflammation: mechanisms and opportunity for drug development Pharmacol Ther 2013 139 189 212 23583354
3 Khatami M Chronic Inflammation: Synergistic interactions of recruiting macrophages (TAMs) and eosinophils (Eos) with host mast cells (MCs) and tumorigenesis in CALTs. M-CSF, suitable biomarker for cancer diagnosis! Cancers (Basel) 2014 6 297 322 24473090
4 Khatami M “Yin and Yang” in inflammation: Duality in innate immune cell function and tumorigenesis Exp Opin Biol Ther 2008 8 1461 72
5 Alrifai M Marsh LM Dicke T Kılıç A Conrad ML Renz H Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model PLoS One 2014 9 e85839 24465740
6 Gandaglia G Briganti A Gontero P Mondaini N Novara G Salonia A The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH) BJU Int 2013 112 432 41 23650937
7 Fischetti F Tedesco F Cross-talk between the complement system and endothelial cells in physiologic conditions and vascular diseases Autoimmunity 2006 39 417 28 16923542
8 Culmsee C Landshamer S Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders Curr Alzheimer Res 2006 3 269 83 17017859
9 Eiró N Vizoso FJ Inflammation and cancer World J Gastrointest Surg 2012 27 62 72 22530080
10 Lamarque D Pathogenesis of gastroduodenal lesions induced by nonsteroidal antiinflammatory drugs Gastroenterol Clin Biol 2004 28 C18 26 15366671
11 Takeuchi K Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility World J Gastroenterol 2012 18 2147 60 22611307
12 Harirforoosh S Asghar W Jamali F Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications J Pharm Pharm Sci 2013 16 821 47 24393558
13 Narsinghani T Sharma R Lead Optimization on conventional NSAIDs: An approach to reduce gastrointestinal toxicity Chem Biol Drug Des 2014 84 1 23 24460671
14 Nandakishore R Ravikiran Y Kiran YR Rajapranathi M Selective cyclooxygenase inhibitors: Current Status Curr Drug Discov Technol 2014 11 127 32 24467591
15 Bresalier RS Sandler RS Quan H Bolognese JA Oxenius B Horgan K Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial N Engl J Med 2005 352 1092 102 15713943
16 Nussmeier NA Whelton AA Brown MT Langford RM Hoeft A Parlow JL Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery N Engl J Med 2005 352 1081 91 15713945
17 Solomon SD McMurray JJ Pfeffer MA Wittes J Fowler R Finn P Adenoma Prevention with Celecoxib (APC) Study Investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention N Engl J Med 2005 352 1071 80 15713944
18 Moore RA Derry S McQuay HJ Cyclo-oxygenase-2 selective inhibitors and nonsteroidal antiinflammatory drugs: balancing gastrointestinal and cardiovascular risk BMC Musculoskelet Disord 2007 3 73 7 17683540
19 Hooper L Brown TJ Elliott R Payne K Roberts C Symmons D The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by nonsteroidal antiinflammatory drugs: Systematic review Br Med J 2004 329 948 52 15475342
20 Ho CW Tse YK Wu B Mulder CJ Chan FK The use of prophylactic gastroprotective therapy in patients with nonsteroidal antiinflammatory drug- and aspirin-associated ulcer bleeding: A cross-sectional study Aliment Pharmacol Ther 2013 37 819 24 23432193
21 McCarberg B Gibofsky A Need to develop new nonsteroidal antiinflammatory drug formulations Clin Ther 2012 34 1954 63 22939163
22 Zhang W Moskowitz RW Nuki G Abramson S Altman RD Arden N OARSI Recommendations for the management of hip and knee osteoarthritis. Part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence Osteoarthritis Cartilage 2007 15 981 100 17719803
23 Lee YC Shmerling RH The benefit of non-pharmacologic therapy to treat symptomatic osteoarthritis Curr Rheumatol Rep 2008 10 5 10 18457605
24 McCarberg B Tenzer P The complexities in the pharmacologic management of osteoarthritis pain Curr Med Res Opin 2013 29 539 48 23489409
25 Kantor ED Lampe JW Kratz M White E Lifestyle factors and inflammation: Associations by body mass index PLoS One 2013 8 e67833 23844105
26 Naska A Trichopoulou A A. Back to the future: The Mediterranean diet paradigm Nutr Metab Cardiovasc Dis 2014 24 216 9 24462051
27 Leone S Ottani A Bertolini A Dual acting antiinflammatory drugs Curr Top Med Chem 2007 7 265 75 17305569
28 Zdunić G Godevac D Milenković M Savikin K Menković N Petrović S Antiinflammatory and gastroprotective properties of Hypericum richeri oil extracts Nat Prod Commun 2010 5 1215 8 20839622
29 Abu-Gharbieh E Shehab NG Khan SA Antiinflammatory and gastroprotective activities of the aqueous extract of Micromeria fruticosa (L.) Druce ssp Serpyllifolia in mice Pak J Pharm Sci 2013 26 799 803 23811461
30 Karoui A Allouche F Deghrigue M Agrebi A Bouraoui A Chabchoub F Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: Antiinflammatory agents with gastroprotective effect in rats Med Chem Res 2014 23 1591 8 24489456
31 Narsinghani T Sharma R Lead Optimization on conventional NSAIDs: An approach to reduce gastrointestinal toxicity Chem Biol Drug Des 2014 84 1 23 24460671
32 Mas R D-002: A product obtained from beeswax Drugs Future 2001 26 731 44
33 Carbajal D Molina V Valdés S Arruzazabala ML Mas R Anti-ulcer activity of higher primary alcohols of beeswax J Pharm Phamacol 1995 47 731 3
34 Carbajal D Molina V Valdés S Arruzazabala ML Rodeiro I Mas R Possible cytoprotective mechanism in rats of D-002 an antiulcerogenic product isolated from beeswax J Pharm Pharmacol 1996 48 858 60 8887738
35 Carbajal D Molina V Noa M Valdes S Arruzazabala ML Aguiar A Effects of D-002 on gastric mucus composition in ethanol-induced ulcer Pharmacol Res 2000 42 329 32 10987992
36 Molina V Valdés S Carbajal D Arruzazabala L Menéndez R Mas R Antioxidant effects of D-002 on gastric mucosa of rats with injury induced experimentally J Med Food 2001 4 79 84 12639416
37 Pérez Y Oyárzabal A Mas R Molina V Jiménez S Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action J Nat Med 2013 67 182 9 22576364
38 Valle M Noa M Mendoza S Oyarzábal A Molina V Mendoza N Effects of D-002 on aspirin-induced ulcers and neutrophil infiltration on the gastric mucosa Revista Cubana de Farmacia (Cuban J Pharm) 2012 46 249 58
39 Menéndez R Amor AM González RM Jiménez S Mas R Inhibition of rat microsomal lipid peroxidation by the oral administration of D-002 Braz J Med Biol Res 2000 33 85 90 10625879
40 Pérez Y González R Amor AM Jiménez S Menéndez R D-002 on antioxidant enzymes in liver and brain of rats Rev CENIC Cien Biol 2002 33 3 5
41 Menéndez R Mas R Amor AM Perez Y González RM Fernández JC Antioxidant effects of D-002 on the in vitro susceptibility in healthy volunteers Arch Med Res 2001 32 436 41 11578760
42 Menéndez R Mas R Illnait J Pérez J Amor AM Fernández JC Effects of D-002 on lipid peroxidation in older subjects J Med Food 2001 4 71 7 12639415
43 López E Illnait J Molina V Oyarzábal A Fernández L Pérez Y Effects of D-002 (beeswax alcohols) on lipid peroxidation in middle-aged and older subjects Lat Am J Pharm 2008 27 695 703
44 Rodriguez I Illnait J Fernandez L Oyarzábal A Fernández L Fernández JC Comparative antioxidant effects of beeswax alcohols and grape seed extract in healthy persons Lat Am J Pharm 2010 29 255 62
45 Carbajal D Molina V Noa M Ravelo Y Mas R Valle M Comparative effects of D-002 (beeswax alcohols), ranitidine and omeprazole on acetic acid-induced ulcer Int J Pharmacy Pharm Sci 2013 5 91 5
46 Carbajal D Molina V Arruzazabala ML Mas R D-002 (Abexol) sobre la ulcera duodenal inducida por cisteamina Rev CENIC Cien Biol 2005 36 167 9
47 Zamora Z Molina V Mas R Ravelo Y Perez Y Oyarzabal A Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats World J Gastroenterol 2014 20 2085 90 24587681
48 Rodriguez I Illnait J Fernandez L Mas R Fernandez L Fernández JC Effects of Abexol® (beeswax alcohols) on gastrointestinal symptoms of middle-aged and older subjects Rev CENIC Cien Biol 2009 40 147 54
49 Fernández JC Rodríguez I Illnait J Fernández L Mas R Pérez Y Effects of Abexol® (beeswax alcohols) in patients with gastric symptoms Revista CENIC Cien Biol 2012 43 9 16
50 Illnait J Terry H Mas R Fernandez L Carbajal D Effects of D-002, a product isolated from beeswax, on gastric symptoms of patients with osteoarthritis treated with piroxicam: A pilot study J Med Food 2005 8 63 8 15857212
51 Illnait J Rodriguez I Molina V Mendoza S Mas R Fernández L Effects of D-002 (beeswax Alcohols) on gastrointestinal symptoms and oxidative markers in middle-aged and older subjects Lat Am J Pharm 2013 32 166 74
52 Fernández L Terry H Quiñones AM Diaz B Hernández ML Illnait J Effects of Abexol in middle-aged and older subjects: an open follow-up Rev CENIC Cien Biol 2008 39 3 8
53 Carbajal D Molina V Valdés S Arruzazabala ML Mas R Magraner J Antiinflammatory activity of D-002: An active product isolated from beeswax Prostaglandins Leukot Essent Fatty Acids 1998 59 235 8 9849648
54 Di Gennaro A Haeggström JZ Targeting leukotriene B4 in inflammation Expert Opin Ther Targets 2014 18 79 93 24090264
55 Warren RP Burger RA Sidwell RW Clark LL Effect of triacontanol on numbers and functions of cells involved in inflammatory responses Proc Soc Exp Biol Med 1992 200 349 52 1615010
56 McBride PT Clark L Krueger GG Evaluation of triacontanol-containing compounds as antiinflammatory agents using guinea pig models J Invest Dermatol 1987 89 380 3 3668280
57 Perez Y Oyarzabal A Molina V Mas R Jiménez S Molina V Effect of D-002 on 5-lipooxygenase activity in vitro Rev Cubana Farm 2012 46 259 66
58 Pérez Y Oyarzábal A Ravelo Y Mas R Jiménez S Molina V Inhibition of cyclooxygenase and 5-lipooxygenase enzymes by D-002 (beeswax alcohols) Top Curr Nutraceutical Res 2014 12 13 8
59 Carbajal D Ravelo Y Molina V Mas R Arruzazabala ML Effect of D-002 on models of acute inflammation Int J Pharm Sci Rev Res 2013 21 62 7
60 Ravelo Y Molina V Carbajal D Arruzazabala ML Mas R Oyarzabal A Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene induced ear edema in mice Lat Am J Pharm 2010 29 1451 4
61 Ravelo Y Molina V Oyarzábal A Pérez Y Noa M Mas R Effects of D-002 on pleural exudates volume and lung injury in rats with carragenan induced pleurisy Int J Pharm Sci Rev Res 2014 [In Press]
62 Ravelo Y Molina V Pérez Y Oyarzábal A Jiménez S Mas R et al. Anti-oedema effects of D-002 and Lyprinol on the carrageenan-induced pleurisy in rats Int J Pharm Sci Rev Res 2013 23 24 8
63 Kolaczkowska E Kubes P Neutrophil recruitment and function in health and inflammation Nat Rev Immunol 2013 13 159 75 23435331
64 Ravelo Y Molina V Carbajal D Fernández L Fernández J Arruzazabala ML Evaluation of antiinflammatory and antinociceptive effects of D-002 (beeswax alcohols) J Nat Med 2010 65 330 5 21258868
65 Carbajal D Molina V Ravelo Y Mas R Effects of D-002, a mixture of beeswax alcohols, on the acetic acid induced writhing test in mice: A comparison with naproxen, aspirin and paracetamol Rev CENIC Cien Biol 2013 44 1 7
66 Molina V Ravelo Y Mas R Carbajal D Arruzazabala ML Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma Lat Am J Pharm 2011 30 1709 13
67 Mendoza S Noa M Valle M Mendoza N Mas R Effects of D-002 on formaldehyde-induced osteoarthritis in rats IOSR J Pharm 2013 3 9 12
68 Mendoza S Noa M Valle M Mendoza N Mas R Ameliorating effects of D-002, a mixture of beeswax alcohols, on monosodium iodoacetate-induced osteoarthritis in rats Int J Pharm Sci Rev Res 2013 19 10 5
69 Rodríguez I Mendoza S Illnait J Mas R Fernández Fernández L Effects of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms: A randomized placebo-controlled study IOSR J Pharm 2012 2 1 9
70 Puente R Illnait J Mas R Carbajal D Mendoza S Fernández JC Evaluation of the effect of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms Korean J Intern Med 2014 29 191 202 24648802
71 Rodeiro I Aleman C Mas R Noa M Briñis F Hernández C Toxicología aguda oral del D-002 en ratas Sprague Dawley Rev CENIC Cien Biol 1995 26 34 6
72 Rodeiro I Alemán C Noa M Menendez R Mas R Hernandez C Preclinical oral toxicology in rats of D-002 a natural drug with antiulcer effects Drug Chem Tox 1998 21 151 62
73 Rodeiro I Aleman C Noa M Rendon A Mas R Fernández SI Oral toxicological studies of D-002 in mice Rev CENIC Cien Biol 1999 30 73 6
74 Alemán CL Rodeiro I Noa M Menéndez R Gámez R Hernández C One-year dog toxicity study of D-002, a mixture of aliphatic alcohols J Appl Toxicol 2001 21 179 84 11404829
75 Rodeiro I Gámez R Acosta P Fernández I Mas R Alemán C Estudio genotoxico del D-002, un producto con actividad antiulcerosa Rev Esp Tox 1998 15 117 21
76 Gámez R Gutiérrez A Arencibia D Curveco D García H In vitro genotoxic potential of D-002 on the blood lymphocytes chromosomal aberration test Lat Am J Pharm 2010 29 459 62
77 Gámez R Fernández I Acosta PC Alemán C Rodeiro I Evaluacion mutagénica del D-002 en el ensayo de micronúcleos en médula ósea en ratas Sprague Dawley de ambos sexos Rev CENIC Cien Biol 1999 30 70 2
78 Rodríguez MD Gámez R Sánchez M García H Developmental toxicity of D-002 a mixture of aliphatic primary alcohols in rats and rabbits J Appl Toxicol 1998 18 313 6 9804430
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.