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Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern

Prostaglandins & other lipid mediators, v.121 pt.A, 2015년, pp.131 - 137  

Ostermann, A.I. ,  Herbers, J. ,  Willenberg, I. ,  Chen, R. ,  Hwang, S.H. ,  Greite, R. ,  Morisseau, C. ,  Gueler, F. ,  Hammock, B.D. ,  Schebb, N.H.

Abstract AI-Helper 아이콘AI-Helper

Epoxides from polyunsaturated fatty acids (PUFAs) are potent lipid mediators. In vivo stabilization of these epoxides by blockade of the soluble epoxide hydrolase (sEH) leads to anti-inflammatory, analgesic and normotensive effects. Therefore, sEH inhibitors (sEHi) are a promising new class of drugs...

주제어

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