MoralesThese authors contributed equally to this work., Merten
(ETH Zurich, Institute for Chemical and Bioengineering)
,
Ataman, Meriç
(É)
,
Badr, Sara
(cole Polytechnique Federale de Lausanne, Institute of Chemical Science and Engineering)
,
Linster, Sven
(ETH Zurich, Institute for Chemical and Bioengineering)
,
Kourlimpinis, Ioannis
(ETH Zurich, Institute for Chemical and Bioengineering)
,
Papadokonstantakis, Stavros
(ETH Zurich, Institute for Chemical and Bioengineering)
,
Hatzimanikatis, Vassily
(Department of Energy and Environment, Chalmers University of Technology)
,
Hungerbühler, Konrad
(É)
Over the past few years, bio-succinic acid from renewable resources has gained increasing attention as a potential bio-derived platform chemical for the detergent/surfactant, ion chelator, food and pharmaceutical markets. Until now, much research was undertaken to lower the production costs of bio-s...
Over the past few years, bio-succinic acid from renewable resources has gained increasing attention as a potential bio-derived platform chemical for the detergent/surfactant, ion chelator, food and pharmaceutical markets. Until now, much research was undertaken to lower the production costs of bio-succinic acid, however a multicriteria sustainability evaluation of established and upcoming production processes from a technical perspective is still lacking in the scientific literature. In this study, we combine metabolic engineering with the most mature technologies for the production of bio-succinic acid from sugar beet and lignocellulosic residues. Downstream technologies such as reactive extraction, electrodialysis and ion exchange are investigated together with different upstream technologies such as neutral pH level-, acidic- and high sugar fermentation including metabolically engineered E. coli strains. Different biorefinery concepts are evaluated considering technical, economic, environmental and process hazard aspects in order to gain a broad sustainability perspective of the technologies. The results reveal that energy integration is a key factor for biorefinery concepts in order to be economically reasonable and to achieve lower environmental impacts compared to the conventional production from non-renewable resources. It was found that metabolically engineered E. coli with resistance at the acidic pH level in the fermentation together with reactive extraction in the purification presents the most environmentally competitive technology. However, E. coli strains with resistance at high sugar concentrations together with reactive extraction are revealed to present the most economically competitive technology for the production of bio-succinic acid. Moreover, both technologies are flagged for higher process hazards and require the right measures to enhance process safety and mitigate environmental loads and worker exposure.Graphic AbstractInnovative pathways for bio-succinic acid production from biomass are investigated regarding their environmental impact, economic feasibility and process hazard by including state of the art metabolic engineering in process modelling.
Over the past few years, bio-succinic acid from renewable resources has gained increasing attention as a potential bio-derived platform chemical for the detergent/surfactant, ion chelator, food and pharmaceutical markets. Until now, much research was undertaken to lower the production costs of bio-succinic acid, however a multicriteria sustainability evaluation of established and upcoming production processes from a technical perspective is still lacking in the scientific literature. In this study, we combine metabolic engineering with the most mature technologies for the production of bio-succinic acid from sugar beet and lignocellulosic residues. Downstream technologies such as reactive extraction, electrodialysis and ion exchange are investigated together with different upstream technologies such as neutral pH level-, acidic- and high sugar fermentation including metabolically engineered E. coli strains. Different biorefinery concepts are evaluated considering technical, economic, environmental and process hazard aspects in order to gain a broad sustainability perspective of the technologies. The results reveal that energy integration is a key factor for biorefinery concepts in order to be economically reasonable and to achieve lower environmental impacts compared to the conventional production from non-renewable resources. It was found that metabolically engineered E. coli with resistance at the acidic pH level in the fermentation together with reactive extraction in the purification presents the most environmentally competitive technology. However, E. coli strains with resistance at high sugar concentrations together with reactive extraction are revealed to present the most economically competitive technology for the production of bio-succinic acid. Moreover, both technologies are flagged for higher process hazards and require the right measures to enhance process safety and mitigate environmental loads and worker exposure.Graphic AbstractInnovative pathways for bio-succinic acid production from biomass are investigated regarding their environmental impact, economic feasibility and process hazard by including state of the art metabolic engineering in process modelling.
A. J. Ragauskas C. K. Williams B. H. Davison G. Britovsek J. Cairney C. A. Eckert W. J. Frederick, Jr. J. P. Hallett D. J. Leak C. L. Liotta J. R. Mielenz R. Murphy R. Templer T. Tschaplinski Science 2006 311 484 489
A. M. Baniel and A. M. Eyal , US Pat. , US5426220 A, 1995
B. Litsanov , M. Brocker , M. Oldiges and M. Bott , Bioprocessing of Renewable Resources to Commodity Bioproducts , John Wiley & Sons, Inc. , 2014 , pp. 435-472 10.1002/9781118845394.ch16
B. G. Hermann M. Patel Appl. Biochem. Biotechnol. 2007 136 361 388
M. Patel , L. Overbeek and R. Weusthuis , Medium and long-term opportunities and risk of the biotechnological production of bulk chemicals from renewable resources: the potential of white biotechnology: the BREW project , Utrecht University, Technology and Society (STS) , Utrecht , 2006
C. S. López-Garzón A. J. J. Straathof Biotechnol. Adv. 2014 32 873 904
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