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Rhodamine B conjugates of triterpenoic acids are cytotoxic mitocans even at nanomolar concentrations

European journal of medicinal chemistry, v.127, 2017년, pp.1 - 9  

Sommerwerk, Sven (Corresponding author.) ,  Heller, Lucie ,  Kerzig, Christoph ,  Kramell, Annemarie E. ,  Csuk, René

Abstract AI-Helper 아이콘AI-Helper

Abstract Triterpenoic acids 1–6 exhibited very low or no cytotoxicity at all, but their corresponding 2,3-di-O-acetyl-piperazinyl amides 13–18 showed low EC50 values for several human tumor cell lines. Their cytotoxicity, however, was also high for the non-malignant mouse fibroblasts NI...

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