[논문]High YBX1 expression indicates poor prognosis and promotes cell migration and invasion in nasopharyngeal carcinoma

Zhou, Lei-lei; Ni, Jie; Feng, Wan-ting; Yao, Rong; Yue, Shun; Zhu, Ya-ning; Tang, Hai-yan; Lv, Ling-yun; Feng, Ji-feng; Zhu, Wei-guo

doi:10.1016/j.yexcr.2017.10.009

High YBX1 expression indicates poor prognosis and promotes cell migration and invasion in nasopharyngeal carcinoma

Experimental cell research, v.361 no.1, 2017년, pp.126 - 134

Zhou, Lei-lei (Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University) , Ni, Jie (Nanjing Medical University Affliated Cancer Hospital, Department of Clinical Cancer Research Center, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research) , Feng, Wan-ting (Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University) , Yao, Rong (Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University) , Yue, Shun (Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University) , Zhu, Ya-ning (Department of Pathology, Huai'an First People's Hospital, Nanjing Medical University) , Tang, Hai-yan (Department of Pathology, Huai'an First People's Hospital, Nanjing Medical University) , Lv, Ling-yun (Department of Otolaryngology, Huai'an First People's Hospital, Nanjing Medical University) , Feng, Ji-feng (Nanjing Medical Universit) , Zhu, Wei-guo

Abstract ▼ AI-Helper

Abstract Y-box binding protein-1 (YBX1) is a multifunctional protein and often acts as an indicator of poor prognosis in cancers. Increasing evidence has shown that the levels of YBX1 protein were closely associated with multidrug resistance, relapse, metastasis and poor prognosis in cancers. However, its role in nasopharyngeal carcinoma (NPC) metastasis remains unknown. In our study, we discovered that the expression of YBX1 was increased in nasopharyngeal carcinoma tissues. YBX1 protein levels positively correlated with T stage and metastasis of NPC patients. Moreover, expression of YBX1 was negatively correlated with membrane E-cadherin levels and positively correlated with Vimentin expression. In vitro, the expression of YBX1 was closely related to the invasive and migratory ability of nasopharyngeal carcinoma cells. Knockdown of YBX1 inhibited migration and invasion in 5–8F cells, and over-expression of YBX1 promoted CNE1 cells migration and invasion. Transforming growth factor-β1 (TGF-β1) treatment led to epithelial-to-mesenchymal transition (EMT) in CNE1 cells accompanied by elevated YBX1 expression. On the contrary, knockdown of YBX1 partially inhibited the TGF-β1-induced CNE1 cell migration, together with changes of EMT-associated markers. Our study revealed that TGF-β1/YBX1 signaling might be one of novel mechanisms mediating EMT in NPC, providing a new target for the treatment of nasopharyngeal carcinoma. Highlights YBX1 overexpressed in cytoplasmic of nasopharyngeal carcinoma cells. YBX1 expression associated with the EMT process in nasopharyngeal carcinoma. TGF-β1 induced YBX1 expression in NPC cell lines. TGF-β1/YBX1 signaling mediated the EMT process in NPC cell lines.

주제어

참고문헌 (43)

Cancer Cell Lo 5 423 2004 10.1016/S1535-6108(04)00119-9 Focus on nasopharyngeal carcinoma

상세보기
Chin. J. Cancer Cao 30 114 2011 10.5732/cjc.010.10377 The prevalence and prevention of nasopharyngeal carcinoma in China

상세보기
Eur. Ann. Otorhinolaryngol. Head Neck Dis. Bensouda 128 79 2011 10.1016/j.anorl.2010.10.003 Treatment for metastatic nasopharyngeal carcinoma

상세보기
Chin. J. Cancer Han 29 145 2010 10.5732/cjc.009.10332 Prognostic factors of 305 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy
Biochim. Biophys. Acta Geiger 1796 293 2009 Metastasis mechanisms
Cancer Res. Gao 72 4883 2012 10.1158/0008-5472.CAN-12-1223 Microenvironmental regulation of epithelial-mesenchymal transitions in cancer

상세보기
Cancer Sci. Iwatsuki 101 293 2010 10.1111/j.1349-7006.2009.01419.x Epithelial-mesenchymal transition in cancer development and its clinical significance

상세보기
J. Mammary Gland Biol. Neoplasia Micalizzi 15 117 2010 10.1007/s10911-010-9178-9 Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression

상세보기
Oral Oncol. Smith 49 287 2013 10.1016/j.oraloncology.2012.10.009 Epithelial to mesenchymal transition in head and neck squamous cell carcinoma

상세보기
Biology Ksiazkiewicz 79 195 2012 Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells
Oncogene Pistore 2017 10.1038/onc.2017.159 DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells

상세보기
Int. J. Oncol. Li 51 158 2017 10.3892/ijo.2017.4007 miR181b5p mediates TGFbeta1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells

상세보기
Oncotarget Ying 8 18348 2017 10.18632/oncotarget.15442 MicroRNA-137 inhibits BMP7 to enhance the epithelial-mesenchymal transition of breast cancer cells

상세보기
Cell Death Dis. Zhang 8 e2838 2017 10.1038/cddis.2017.114 Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial-mesenchymal transition and metastasis

상세보기
Cold Spring Harbor Perspect. Biol. Morikawa 8 2016 10.1101/cshperspect.a021873 TGF-beta and the TGF-beta family: context-dependent roles in cell and tissue physiology

상세보기
J. Mol. Histol. Zhang 43 297 2012 10.1007/s10735-012-9392-4 Evaluation of the prognostic value of TGF-beta superfamily type I receptor and TGF-beta type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays

상세보기
Mol. Cancer Salvo 13 112 2014 10.1186/1476-4598-13-112 Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer

상세보기
Cell Res. Xu 19 156 2009 10.1038/cr.2009.5 TGF-beta-induced epithelial to mesenchymal transition

상세보기
Mol. Cancer Lyu 13 51 2014 10.1186/1476-4598-13-51 TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness

상세보기
Sci. Rep. Wu 7 42507 2017 10.1038/srep42507 High FMNL3 expression promotes nasopharyngeal carcinoma cell metastasis: role in TGF-beta1-induced epithelia-to-mesenchymal transition

상세보기
Cell Yang 117 927 2004 10.1016/j.cell.2004.06.006 Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

상세보기
Cancer Res. Shi 69 7180 2009 10.1158/0008-5472.CAN-08-4470 Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition

상세보기
Int. J. Dev. Biol. Peinado 48 365 2004 10.1387/ijdb.041794hp Transcriptional regulation of cadherins during development and carcinogenesis

상세보기
BioEssays: News Rev. Mol. Cell. Dev. Biol. Kohno 25 691 2003 10.1002/bies.10300 The pleiotropic functions of the Y-box-binding protein, YB-1

상세보기
Biochem. Biokhim. Eliseeva 76 1402 2011 10.1134/S0006297911130049 Y-box-binding protein 1 (YB-1) and its functions

상세보기
Mod. Pathol.: Off. J. US Can. Acad. Pathol. Inc. Tay 22 282 2009 10.1038/modpathol.2008.181 Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer

상세보기
RNA Liu 21 1159 2015 10.1261/rna.045559.114 Noncoding RNAs that associate with YB-1 alter proliferation in prostate cancer cells

상세보기
Biomark. Med. Zhao 8 581 2014 10.2217/bmm.14.4 Association between higher expression of YB-1 and poor prognosis in early-stage extranodal nasal-type natural killer/T-cell lymphoma

상세보기
Int. J. Cancer Lasham 139 1157 2016 10.1002/ijc.30137 A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line

상세보기
Oncotarget Zhao 7 82139 2016 10.18632/oncotarget.10080 YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma

상세보기
Cancer Res. To 70 2840 2010 10.1158/0008-5472.CAN-09-3155 Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance

상세보기
J. Surg. Oncol. Wu 105 724 2012 10.1002/jso.23030 Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer

상세보기
Cancer Cell Evdokimova 15 402 2009 10.1016/j.ccr.2009.03.017 Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition

상세보기
J. Biol. Chem. Higashi 278 43470 2003 10.1074/jbc.M302339200 Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3

상세보기
Cell Tissue Res. Xiong 355 365 2014 10.1007/s00441-013-1752-1 NT5E and FcGBP as key regulators of TGF-1-induced epithelial-mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer

상세보기
Oncotarget Gopal 6 13718 2015 10.18632/oncotarget.3764 YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment

상세보기
BMC Cancer Jung 14 328 2014 10.1186/1471-2407-14-328 YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells

상세보기
Clin. Lung Cancer Hyogotani 13 375 2012 10.1016/j.cllc.2011.11.006 Association of nuclear YB-1 localization with lung resistance-related protein and epidermal growth factor receptor expression in lung cancer

상세보기
Carcinogenesis Tian 36 41 2015 10.1093/carcin/bgu230 Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis and poor prognosis in human nasopharyngeal cancer

상세보기
Gynecol. Oncol. Nishio 132 703 2014 10.1016/j.ygyno.2014.01.045 Nuclear Y-box-binding protein-1 is a poor prognostic marker and related to epidermal growth factor receptor in uterine cervical cancer

상세보기
BMC Cancer Lim 17 201 2017 10.1186/s12885-017-3187-7 YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro

상세보기
Oncotarget Prabhu 6 29396 2015 10.18632/oncotarget.5120 Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-kappaB in colon cancer

상세보기
J. Exp. Clin. Cancer Res.: CR Zhang 35 109 2016 10.1186/s13046-016-0384-1 YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/beta-catenin signaling pathway

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

High YBX1 expression indicates poor prognosis and promotes cell migration and invasion in nasopharyngeal carcinoma

Abstract ▼ AI-Helper

주제어

참고문헌 (43)

이 논문을 인용한 문헌

관련 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트