[논문]Role of interferons in SLE

Bengtsson, Anders A.; Rö; nnblom, Lars

doi:10.1016/j.berh.2017.10.003

Role of interferons in SLE

Best practice & research. Clinical rheumatology, v.31 no.3, 2017년, pp.415 - 428

Bengtsson, Anders A. (Lund University, Skå) , Rönnblom, Lars (ne University Hospital, Department of Clinical Sciences Lund, Rheumatology, 22185 Lund, Sweden)

Abstract ▼ AI-Helper

Abstract Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that affects many different organ systems, with excessive production of type I interferons (IFNs) and autoantibodies against nucleic acids as hallmarks. Activation of the type I IFN system in SLE is due to continuous stimulation of plasmacytoid dendritic cells by endogenous nucleic acids, leading to sustained type I IFN production. This is reflected by an overexpression of type I IFN-regulated genes or an IFN signature. Type I IFNs have effects on both the innate and adaptive immune systems, which contribute to both loss of tolerance and the autoimmune disease process. In this review, we discuss the current understanding of IFNs in SLE, focusing on their regulation, the influence of genetic background, and environmental factors and therapies that are under development aiming to inhibit the type I IFN system in SLE.

주제어

참고문헌 (98)

Trends Immunol Ronnblom 22 8 427 2001 10.1016/S1471-4906(01)01955-X An etiopathogenic role for the type I IFN system in SLE

상세보기
Semin Immunol Ronnblom 23 2 113 2011 10.1016/j.smim.2011.01.009 The type I interferon system in the development of lupus

상세보기
Autoimmun Rev Smith 10 1 43 2010 10.1016/j.autrev.2010.08.016 Systemic lupus erythematosus: clinical presentations

상세보기
N. Engl J Med Tsokos 365 22 2110 2011 10.1056/NEJMra1100359 Systemic lupus erythematosus

상세보기
Transl Res J Lab Clin Med Crow 165 2 296 2015 Targeting of type I interferon in systemic autoimmune diseases
Autoimmun Rev Yaniv 14 1 75 2015 10.1016/j.autrev.2014.10.003 A volcanic explosion of autoantibodies in systemic lupus erythematosus: a diversity of 180 different antibodies found in SLE patients

상세보기
N. Engl J Med Arbuckle 349 16 1526 2003 10.1056/NEJMoa021933 Development of autoantibodies before the clinical onset of systemic lupus erythematosus

상세보기
Autoimmun Rev Agmon-Levin 11 8 593 2012 10.1016/j.autrev.2011.10.020 Systemic lupus erythematosus one disease or many?

상세보기
J Exp Med Bennett 197 6 711 2003 10.1084/jem.20021553 Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

상세보기
Curr Opin Rheumatol Crow 26 5 467 2014 10.1097/BOR.0000000000000087 Advances in understanding the role of type I interferons in systemic lupus erythematosus

상세보기
Curr Opin Rheumatol Ronnblom 25 2 248 2013 10.1097/BOR.0b013e32835c7e32 The interferon signature in autoimmune diseases

상세보기
Nature Bialas 546 7659 539 2017 10.1038/nature22821 Microglia-dependent synapse loss in type I interferon-mediated lupus

상세보기
Trends Microbiol Gurtler 21 8 413 2013 10.1016/j.tim.2013.04.004 Innate immune detection of microbial nucleic acids

상세보기
Nat Immunol Kawai 11 5 373 2010 10.1038/ni.1863 The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

상세보기
EMBO J Rigby 33 6 542 2014 10.1002/embj.201386117 RNA: DNA hybrids are a novel molecular pattern sensed by TLR9

상세보기
Biochimie Fitzgerald-Bocarsly 89 6-7 843 2007 10.1016/j.biochi.2007.04.018 The role of type I interferon production by dendritic cells in host defense

상세보기
Nat Rev Immunol Swiecki 15 8 471 2015 10.1038/nri3865 The multifaceted biology of plasmacytoid dendritic cells

상세보기
Science Liu 347 6227 aaa2630 2015 10.1126/science.aaa2630 Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

상세보기
Annu Rev Immunol Wu 32 461 2014 10.1146/annurev-immunol-032713-120156 Innate immune sensing and signaling of cytosolic nucleic acids

상세보기
J Immunol Bave 171 6 3296 2003 10.4049/jimmunol.171.6.3296 Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG

상세보기
Arthritis Rheum Lovgren 54 6 1917 2006 10.1002/art.21893 Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjogren's syndrome autoantigen-associated RNA

상세보기
Autoimmun Rev Pinegin 14 7 633 2015 10.1016/j.autrev.2015.03.002 Neutrophil extracellular traps and their role in the development of chronic inflammation and autoimmunity

상세보기
Proc Natl Acad Sci U S A Hakkim 107 21 9813 2010 10.1073/pnas.0909927107 Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

상세보기
Arthritis Res Ther Leffler 17 205 2015 10.1186/s13075-015-0726-y A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources

상세보기
Sci Transl Med Garcia-Romo 3 73 73ra20 2011 10.1126/scitranslmed.3001201 Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

상세보기
J Exp Med Caielli 213 5 697 2016 10.1084/jem.20151876 Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

상세보기
Nat Med Lood 22 2 146 2016 10.1038/nm.4027 Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

상세보기
Arthritis Rheumatol Mavragani 68 11 2686 2016 10.1002/art.39795 Expression of long interspersed nuclear element 1 retroelements and induction of type I interferon in patients with systemic autoimmune disease

상세보기
Annu Rev Immunol Schneider 32 513 2014 10.1146/annurev-immunol-032713-120231 Interferon-stimulated genes: a complex web of host defenses

상세보기
Trends Immunol Hoffmann 36 3 124 2015 10.1016/j.it.2015.01.004 Interferons and viruses: an evolutionary arms race of molecular interactions

상세보기
Nat Rev Immunol Platanias 5 5 375 2005 10.1038/nri1604 Mechanisms of type-I- and type-II-interferon-mediated signalling

상세보기
Lupus Barbhaiya 23 6 588 2014 10.1177/0961203314530488 Ultraviolet radiation and systemic lupus erythematosus

상세보기
Semin Immunopathol Kuhn 38 1 97 2016 10.1007/s00281-015-0550-0 Lupus erythematosus revisited

상세보기
Nat Immunol Wack 16 8 802 2015 10.1038/ni.3212 Guarding the frontiers: the biology of type III interferons

상세보기
J Invest Dermatol Zahn 131 1 133 2011 10.1038/jid.2010.244 Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFNlambda) in cutaneous lupus erythematosus

상세보기
J Biol Chem Kemp 290 19 12184 2015 10.1074/jbc.M115.649301 UV light potentiates STING (stimulator of interferon genes)-dependent innate immune signaling through deregulation of ULK1 (Unc51-like kinase 1)

상세보기
Expert Opin Drug Saf Rubin 14 3 361 2015 10.1517/14740338.2015.995089 Drug-induced lupus

상세보기
Nat Rev Mol Cell Biol Biggar 16 1 5 2015 10.1038/nrm3915 Non-histone protein methylation as a regulator of cellular signalling and function

상세보기
Arthritis Rheum Deapen 35 3 311 1992 10.1002/art.1780350310 A revised estimate of twin concordance in systemic lupus erythematosus

상세보기
Nat Genet Bentham 47 12 1457 2015 10.1038/ng.3434 Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

상세보기
J Autoimmun Cui 41 25 2013 10.1016/j.jaut.2013.01.008 Genetic susceptibility to SLE: recent progress from GWAS

상세보기
Curr Opin Rheumatol Deng 26 5 482 2014 10.1097/BOR.0000000000000086 Advances in lupus genetics and epigenetics

상세보기
Curr Opin Rheumatol Chen 29 5 423 2017 10.1097/BOR.0000000000000411 Genetic advances in systemic lupus erythematosus: an update

상세보기
Curr Opin Immunol Bronson 24 5 530 2012 10.1016/j.coi.2012.07.008 The genetics of type I interferon in systemic lupus erythematosus

상세보기
Arthritis Rheum Niewold 58 8 2481 2008 10.1002/art.23613 Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients

상세보기
Hum Mol Genet Berggren 24 12 3571 2015 10.1093/hmg/ddv095 IFN-alpha production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

상세보기
PLoS One Bolin 8 12 e84450 2013 10.1371/journal.pone.0084450 Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis

상세보기
Arthritis Rheum Crow 63 12 3661 2011 10.1002/art.30603 Lupus: how much “complexity” is really (just) genetic heterogeneity?

상세보기
Hum Mol Genet Sigurdsson 17 18 2868 2008 10.1093/hmg/ddn184 A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

상세보기
Ann Rheum Dis Svenungsson 69 5 834 2010 10.1136/ard.2009.115535 A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

상세보기
Ann Rheum Dis Olsson 2017 10.1136/annrheumdis-2017-211287 A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

상세보기
Nat Genet Zhao 49 3 433 2017 10.1038/ng.3782 A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

상세보기
Proc Natl Acad Sci U S A Jacob 109 2 E59 2012 10.1073/pnas.1113251108 Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

상세보기
Antioxidants Redox Signal Kelkka 21 16 2231 2014 10.1089/ars.2013.5828 Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature

상세보기
Curr Opin Immunol Elkon 24 6 665 2012 10.1016/j.coi.2012.08.004 Complement, interferon and lupus

상세보기
Nat Genet Lee-Kirsch 39 9 1065 2007 10.1038/ng2091 Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus

상세보기
Arthritis Rheum Lood 60 10 3081 2009 10.1002/art.24852 C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

상세보기
J Immunol Santer 185 8 4738 2010 10.4049/jimmunol.1001731 C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes

상세보기
J Interferon Cytokine Res Offic J Int Soc Interferon Cytokine Res Hertzog 31 1 5 2011 10.1089/jir.2010.0126 Systems biology of interferon responses

상세보기
Nat Rev Immunol Gonzalez-Navajas 12 2 125 2012 10.1038/nri3133 Immunomodulatory functions of type I interferons

상세보기
Trends Immunol Schreiber 36 3 139 2015 10.1016/j.it.2015.01.002 The molecular basis for functional plasticity in type I interferon signaling

상세보기
Nat Rev Immunol McNab 15 2 87 2015 10.1038/nri3787 Type I interferons in infectious disease

상세보기
Trends Mol Med Grammatikos 18 2 101 2012 10.1016/j.molmed.2011.10.005 Immunodeficiency and autoimmunity: lessons from systemic lupus erythematosus

상세보기
Arthritis Rheum Eloranta 65 4 853 2013 10.1002/art.37821 Disease mechanisms in rheumatology-tools and pathways: plasmacytoid dendritic cells and their role in autoimmune rheumatic diseases

상세보기
Clin Dev Immunol Alunno 2012 823085 2012 10.1155/2012/823085 Balance between regulatory T and Th17 cells in systemic lupus erythematosus: the old and the new

상세보기
Curr Opin Immunol Jackson 33 70 2015 10.1016/j.coi.2015.01.018 B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production

상세보기
Sci Rep Lopez 6 20651 2016 10.1038/srep20651 A pathogenic IFNalpha, BLyS and IL-17 axis in systemic lupus erythematosus patients

상세보기
Cytokine Vazquez 74 2 318 2015 10.1016/j.cyto.2015.02.007 B cells responses and cytokine production are regulated by their immune microenvironment

상세보기
Arthritis Rheum Thacker 64 9 2975 2012 10.1002/art.34504 Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis

상세보기
Curr Opin Rheumatol Knight 25 5 597 2013 10.1097/BOR.0b013e328363eba3 Cardiovascular disease in lupus: insights and updates

상세보기
J Interferon Cytokine Res Official J Int Soc Interferon Cytokine Res Savan 34 5 318 2014 10.1089/jir.2013.0117 Post-transcriptional regulation of interferons and their signaling pathways

상세보기
Immunol Rev Swiecki 234 1 142 2010 10.1111/j.0105-2896.2009.00881.x Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

상세보기
Arthritis Rheum Eloranta 60 8 2418 2009 10.1002/art.24686 Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

상세보기
Arthritis Rheum Berggren 64 10 3409 2012 10.1002/art.34599 B lymphocytes enhance interferon-alpha production by plasmacytoid dendritic cells

상세보기
Ann Rheum Dis Leonard 75 9 1728 2016 10.1136/annrheumdis-2015-208055 Activated T cells enhance interferon-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

상세보기
J Immunol Hagberg 186 9 5085 2011 10.4049/jimmunol.1003349 IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1beta and LFA-1

상세보기
Life Sci Privratsky 87 3-4 69 2010 10.1016/j.lfs.2010.06.001 PECAM-1: conflicts of interest in inflammation

상세보기
J Autoimmun Clement 56 23 2015 10.1016/j.jaut.2014.09.002 Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo

상세보기
Sci Transl Med Duffau 2 47 47ra63 2010 10.1126/scitranslmed.3001001 Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus

상세보기
Blood Lood 116 11 1951 2010 10.1182/blood-2010-03-274605 Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease

상세보기
Clin Transl Immunol Oon 5 5 e79 2016 10.1038/cti.2016.26 Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathway

상세보기
Arthritis Rheumatol Furumoto 69 1 148 2017 10.1002/art.39818 Tofacitinib ameliorates murine lupus and its associated vascular dysfunction

상세보기
Ann Rheum Dis Khamashta 75 11 1909 2016 10.1136/annrheumdis-2015-208562 Sifalimumab, an anti-interferon-alpha monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

상세보기
Ann Rheum Dis Kalunian 75 1 196 2016 10.1136/annrheumdis-2014-206090 A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-alpha) in patients with systemic lupus erythematosus (ROSE)

상세보기
Arthritis Rheumatol Furie 69 2 376 2017 10.1002/art.39962 Anifrolumab, an anti-interferon-alpha receptor monoclonal antibody, in moderate-to-severe systemic lupus erythematosus

상세보기
J Immunol Sun 190 6 2536 2013 10.4049/jimmunol.1202689 Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice

상세보기
Arthritis Rheum Martin 68 Suppl 10 2016 BIIB059, an anti-BDCA2 monoclonal antibody, demonstrates acceptable safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects in a phase 1 study with single ascending doses (SAD) in healthy volunteers
EMBO Mol Med Pellerin 7 4 464 2015 10.15252/emmm.201404719 Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

상세보기
Arthritis Rheum Ichikawa 64 2 493 2012 10.1002/art.33333 Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

상세보기
Nat Immunol Volkman 15 5 415 2014 10.1038/ni.2872 The enemy within: endogenous retroelements and autoimmune disease

상세보기
Arthritis Rheum Furie 63 12 3918 2011 10.1002/art.30613 A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

상세보기
Lancet Navarra 377 9767 721 2011 10.1016/S0140-6736(10)61354-2 Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

상세보기
Arthritis Res Ther Yao 12 Suppl 1 S6 2010 10.1186/ar2887 Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNalpha antibody, in systemic lupus erythematosus

상세보기
Lupus Bengtsson 9 9 664 2000 10.1191/096120300674499064 Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

상세보기
J Exp Med Rodero 214 5 1547 2017 10.1084/jem.20161451 Detection of interferon alpha protein reveals differential levels and cellular sources in disease

상세보기
Proc Natl Acad Sci U S A Baechler 100 5 2610 2003 10.1073/pnas.0337679100 Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

상세보기
Ann Rheum Dis Landolt-Marticorena 68 9 1440 2009 10.1136/ard.2008.093146 Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus

상세보기
J Mol Med Strauss 95 7 753 2017 10.1007/s00109-017-1515-7 Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Role of interferons in SLE

Abstract ▼ AI-Helper

주제어

참고문헌 (98)

이 논문을 인용한 문헌

관련 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트