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Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity?

Archives of medical research, v.48 no.5, 2017년, pp.401 - 413  

Vargas-Castillo, Ariana (Address reprint requests to: Armando R. Tovar, Instituto Nacional de Ciencias Mé) ,  Fuentes-Romero, Rebeca (dicas y Nutrició) ,  Rodriguez-Lopez, Leonardo A. (n Salvador Zubirá) ,  Torres, Nimbe (n, Depto. Fisiologí) ,  Tovar, Armando R. (a de la Nutrició)

Abstract AI-Helper 아이콘AI-Helper

Obesity is characterized by an excess of white adipose tissue (WAT). Recent evidence has demonstrated that WAT can change its phenotype to a brown-like adipose tissue known as beige/brite adipose tissue. This transition is characterized by an increase in thermogenic capacity mediated by uncoupling p...

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참고문헌 (135)

  1. Lib. I. De Quadrupedibus Viviparis Gessner 1551 Gesneri medici Tigurine Historiae Animalium 

  2. Science (New York, NY) Smith 140 199 1963 10.1126/science.140.3563.199 Brown fat: thermogenic effector of arousal in hibernators 

  3. Science (New York, NY) Smalley 140 1333 1963 10.1126/science.140.3573.1333 Brown fat: thermogenic effect during arousal from hibernation in the bat 

  4. Eur J Biochem Nedergaard 95 139 1979 10.1111/j.1432-1033.1979.tb12948.x Norepinephrine-stimulated fatty-acid release and oxygen consumption in isolated hamster brown-fat cells. Influence of buffers, albumin, insulin and mitochondrial inhibitors 

  5. Physiol Rev Nicholls 64 1 1984 10.1152/physrev.1984.64.1.1 Thermogenic mechanisms in brown fat 

  6. Essays Biochem Cannon 20 110 1985 The biochemistry of an inefficient tissue: brown adipose tissue 

  7. Biochim Biophys Acta Klingenspor 1777 637 2008 10.1016/j.bbabio.2008.03.006 An ancient look at UCP1 

  8. J S C Med Assoc Hanna 62 362 1966 A survey of smoking among the students of Spartanburg County, S. C. 

  9. Nat Rev Mol Cell Biol Wang 17 691 2016 10.1038/nrm.2016.96 Control of brown and beige fat development 

  10. Nat Rev Mol Cell Biol Inagaki 17 480 2016 10.1038/nrm.2016.62 Transcriptional and epigenetic control of brown and beige adipose cell fate and function 

  11. N Engl J Med Cypess 360 1509 2009 10.1056/NEJMoa0810780 Identification and importance of brown adipose tissue in adult humans 

  12. N Engl J Med van Marken Lichtenbelt 360 1500 2009 10.1056/NEJMoa0808718 Cold-activated brown adipose tissue in healthy men 

  13. Nat Med Harms 19 1252 2013 10.1038/nm.3361 Brown and beige fat: development, function and therapeutic potential 

  14. J Anat Heaton 112 35 1972 The distribution of brown adipose tissue in the human 

  15. Nat Med Lidell 19 631 2013 10.1038/nm.3017 Evidence for two types of brown adipose tissue in humans 

  16. Int J Cardiol Aldiss 228 265 2017 10.1016/j.ijcard.2016.11.074 ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk 

  17. Front Physiol Busiello 6 36 2015 10.3389/fphys.2015.00036 Mitochondrial uncoupling proteins and energy metabolism 

  18. Br Med Bull Hull 22 92 1966 10.1093/oxfordjournals.bmb.a070447 The structure and function of brown adipose tissue 

  19. Biochim Biophys Acta Nedergaard 1504 82 2001 10.1016/S0005-2728(00)00247-4 UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency 

  20. Biomed Res Int Wankhade 2016 2365609 2016 10.1155/2016/2365609 Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue 

  21. Brain Beh Ramsden 2 468 2012 10.1002/brb3.55 Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction 

  22. Genes & development Wu 27 234 2013 10.1101/gad.211649.112 Adaptive thermogenesis in adipocytes: is beige the new brown? 

  23. Biochimica et biophysica acta Lee 1842 358 2014 10.1016/j.bbadis.2013.05.011 Adipose tissue plasticity from WAT to BAT and in between 

  24. Int J Obes (Lond). (2005) Kozak 32 Suppl 7 S32 2008 10.1038/ijo.2008.236 UCP1: its involvement and utility in obesity 

  25. Nature Lowell 404 652 2000 10.1038/35007527 Towards a molecular understanding of adaptive thermogenesis 

  26. Int J Obes Suppl Cereijo 5 Suppl 1 S40 2015 10.1038/ijosup.2015.10 Non-sympathetic control of brown adipose tissue 

  27. J Biol Chem Barbera 276 1486 2001 10.1074/jbc.M006246200 Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell 

  28. J Biol Chem Tai 271 29909 1996 10.1074/jbc.271.47.29909 Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation 

  29. Curr Med Chem Villarroya 11 795 2004 10.2174/0929867043455747 Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes 

  30. Cell Metab Cao 24 3057 2004 p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene 

  31. Mol Endocrinol Yubero 12 1023 1998 10.1210/mend.12.7.0137 Dominant negative regulation by c-Jun of transcription of the uncoupling protein-1 gene through a proximal cAMP-regulatory element: a mechanism for repressing basal and norepinephrine-induced expression of the gene before brown adipocyte differentiation 

  32. Biochim Biophys Acta Bonet 1831 969 2013 10.1016/j.bbalip.2012.12.002 Pharmacological and nutritional agents promoting browning of white adipose tissue 

  33. Biochem Biophys Res Commun Yubero 198 653 1994 10.1006/bbrc.1994.1095 CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter 

  34. Mol Cell Dempersmier 57 235 2015 10.1016/j.molcel.2014.12.005 Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat 

  35. Biochim Biophys Acta Mueller 1842 352 2014 10.1016/j.bbadis.2013.05.031 Understanding the variegation of fat: novel regulators of adipocyte differentiation and fat tissue biology 

  36. Cell Puigserver 92 829 1998 10.1016/S0092-8674(00)81410-5 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis 

  37. Nature Bostrom 481 463 2012 10.1038/nature10777 A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis 

  38. Nature Handschin 454 463 2008 10.1038/nature07206 The role of exercise and PGC1α in inflammation and chronic disease 

  39. Genes Dev Rosen 14 1293 2000 10.1101/gad.14.11.1293 Transcriptional regulation of adipogenesis 

  40. Nat Rev Cardiol Hassan 9 689 2012 10.1038/nrcardio.2012.148 Adipose tissue: friend or foe? 

  41. J Mol Endocrinol Salma 36 139 2006 10.1677/jme.1.01918 Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo 

  42. Nature Seale 454 961 2008 10.1038/nature07182 PRDM16 controls a brown fat/skeletal muscle switch 

  43. Dev Cell Park 26 393 2013 10.1016/j.devcel.2013.07.002 A multifunctional protein, EWS, is essential for early brown fat lineage determination 

  44. Nature Kajimura 460 1154 2009 10.1038/nature08262 Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex 

  45. J Biol Chem Hondares 286 43112 2011 10.1074/jbc.M111.252775 Peroxisome proliferator-activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC-1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16 

  46. Cell Metab Ohno 15 395 2012 10.1016/j.cmet.2012.01.019 PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein 

  47. FEBS letters Young 167 10 1984 10.1016/0014-5793(84)80822-4 Brown adipose tissue in the parametrial fat pad of the mouse 

  48. Am J Physiol Cell Physiol Himms-Hagen 279 C670 2000 10.1152/ajpcell.2000.279.3.C670 Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes 

  49. Physiol Rev Cannon 84 277 2004 10.1152/physrev.00015.2003 Brown adipose tissue: function and physiological significance 

  50. Science (New York, NY) Ishibashi 328 1113 2010 10.1126/science.1190816 Medicine. Beige can be slimming 

  51. J Biol Chem Petrovic 285 7153 2010 10.1074/jbc.M109.053942 

  52. Cell Metab Long 19 810 2014 10.1016/j.cmet.2014.03.025 A smooth muscle-like origin for beige adipocytes 

  53. Cell Metab Vishvanath 23 350 2016 10.1016/j.cmet.2015.10.018 Pdgfrbeta+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice 

  54. Proc Natl Acad Sci USA Schulz 108 143 2011 10.1073/pnas.1010929108 Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat 

  55. Proc Natl Acad Sci USA Wang 111 14466 2014 10.1073/pnas.1412685111 Ebf2 is a selective marker of brown and beige adipogenic precursor cells 

  56. Diabetes Metab Res Rev Fu 31 433 2015 10.1002/dmrr.2600 Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue 

  57. Nat Cell Biol Rosenwald 15 659 2013 10.1038/ncb2740 Bi-directional interconversion of brite and white adipocytes 

  58. Cell Metab Kajimura 22 546 2015 10.1016/j.cmet.2015.09.007 Brown and Beige Fat: Physiological Roles beyond Heat Generation 

  59. Cell Metab Shao 23 1167 2016 10.1016/j.cmet.2016.04.023 Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program 

  60. Cell Bartel 136 215 2009 10.1016/j.cell.2009.01.002 MicroRNAs: target recognition and regulatory functions 

  61. PLoS Biol Mori 10 e1001314 2012 10.1371/journal.pbio.1001314 Essential role for miR-196a in brown adipogenesis of white fat progenitor cells 

  62. Stem cells (Dayton, Ohio) Karbiener 32 1578 2014 10.1002/stem.1603 MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes 

  63. Diabetes Hu 64 2056 2015 10.2337/db14-1117 miR-30 promotes thermogenesis and the development of beige fat by targeting RIP140 

  64. Nat Commun Chen 4 1769 2013 10.1038/ncomms2742 miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit 

  65. PLoS Genet Liu 9 e1003626 2013 10.1371/journal.pgen.1003626 miR-133a regulates adipocyte browning in vivo 

  66. Nat Cell Biol Trajkovski 14 1330 2012 10.1038/ncb2612 MyomiR-133 regulates brown fat differentiation through Prdm16 

  67. Metabolism Sun 63 272 2014 10.1016/j.metabol.2013.10.004 MiR-27 orchestrates the transcriptional regulation of brown adipogenesis 

  68. Diabetes Kong 64 393 2015 10.2337/db14-0395 Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue 

  69. Cell Metab Fu 34 4130 2014 MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function 

  70. Cell Wu 150 366 2012 10.1016/j.cell.2012.05.016 Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human 

  71. PloS one Sharp 7 e49452 2012 10.1371/journal.pone.0049452 Human BAT possesses molecular signatures that resemble beige/brite cells 

  72. Am J Physiol Endocrinol Metab Walden 302 E19 2012 10.1152/ajpendo.00249.2011 Recruited vs. nonrecruited molecular signatures of brown, “brite”, and white adipose tissues 

  73. Adipocyte Lidell 3 63 2014 10.4161/adip.26896 Two types of brown adipose tissue in humans 

  74. J Clin Invest Seale 121 96 2011 10.1172/JCI44271 Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice 

  75. Cell Metab Jespersen 17 798 2013 10.1016/j.cmet.2013.04.011 A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans 

  76. Am J Physiol Endocrinol Metab de Jong 308 E1085 2015 10.1152/ajpendo.00023.2015 A stringent validation of mouse adipose tissue identity markers 

  77. Int J Obes (Lond) Wang 39 967 2015 10.1038/ijo.2015.23 Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) alpha1 

  78. Cell Metab Seale 6 38 2007 10.1016/j.cmet.2007.06.001 Transcriptional control of brown fat determination by PRDM16 

  79. J Cell Physiol Walden 218 444 2009 10.1002/jcp.21621 Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes 

  80. J Clin Invest Stanford 123 215 2013 10.1172/JCI62308 Brown adipose tissue regulates glucose homeostasis and insulin sensitivity 

  81. Cell Chevalier 163 1360 2015 10.1016/j.cell.2015.11.004 Gut Microbiota Orchestrates Energy Homeostasis during Cold 

  82. Nat Med Suarez-Zamorano 21 1497 2015 10.1038/nm.3994 Microbiota depletion promotes browning of white adipose tissue and reduces obesity 

  83. Cell Metab Sellayah 14 478 2011 10.1016/j.cmet.2011.08.010 Orexin is required for brown adipose tissue development, differentiation, and function 

  84. J Biol Chem Guerra 271 2076 1996 10.1074/jbc.271.4.2076 Triiodothyronine induces the transcription of the uncoupling protein gene and stabilizes its mRNA in fetal rat brown adipocyte primary cultures 

  85. Am J Physiol Cell Physiol Lee 302 C463 2012 10.1152/ajpcell.00010.2011 Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes 

  86. Nat Med Cannon 16 965 2010 10.1038/nm0910-965 Thyroid hormones: igniting brown fat via the brain 

  87. FASEB J Bagchi 27 3257 2013 10.1096/fj.12-221812 Vascular endothelial growth factor is important for brown adipose tissue development and maintenance 

  88. Diabetes Zhang 63 514 2014 10.2337/db13-1106 Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling 

  89. Cell Rao 157 1279 2014 10.1016/j.cell.2014.03.065 Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis 

  90. Cell Metab Roberts 19 96 2014 10.1016/j.cmet.2013.12.003 β-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors 

  91. J Clin Invest Bordicchia 122 1022 2012 10.1172/JCI59701 Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes 

  92. Genes Dev Fisher 26 271 2012 10.1101/gad.177857.111 FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis 

  93. Nature Watanabe 439 84 2006 10.1038/nature04330 Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation 

  94. Cell Metab Thomas 10 167 2009 10.1016/j.cmet.2009.08.001 TGR5-mediated bile acid sensing controls glucose homeostasis 

  95. Nature Schulz 495 379 2013 10.1038/nature11943 Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat 

  96. Nature Tseng 454 1000 2008 10.1038/nature07221 New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure 

  97. Proc Natl Acad Sci USA Qian 110 E798 2013 10.1073/pnas.1215236110 BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis 

  98. Cell Whittle 149 871 2012 10.1016/j.cell.2012.02.066 BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions 

  99. PloS One Madsen 5 e11391 2010 10.1371/journal.pone.0011391 UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity 

  100. Science (New York, NY) Vegiopoulos 328 1158 2010 10.1126/science.1186034 Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes 

  101. Cell Metab Cypess 21 33 2015 10.1016/j.cmet.2014.12.009 Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist 

  102. Obesity (Silver Spring) Verty 17 254 2009 10.1038/oby.2008.509 The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure 

  103. J Mol Cell Biol Ma 4 88 2012 10.1093/jmcb/mjs001 Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity 

  104. Br J Pharmacol Baskaran 173 2369 2016 10.1111/bph.13514 Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms 

  105. Endocrinology Mercader 147 5325 2006 10.1210/en.2006-0760 Remodeling of white adipose tissue after retinoic acid administration in mice 

  106. J Biol Chem Alvarez 270 5666 1995 10.1074/jbc.270.10.5666 A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene 

  107. J Physiol Matta 578 397 2007 10.1113/jphysiol.2006.121988 TRPV1 is a novel target for omega-3 polyunsaturated fatty acids 

  108. Sci Rep Kim 5 18013 2015 10.1038/srep18013 Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system 

  109. Nat Commun Quesada-Lopez 7 13479 2016 10.1038/ncomms13479 The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes 

  110. Food Chem Alberdi 141 1530 2013 10.1016/j.foodchem.2013.03.085 Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats 

  111. Cancer Res Tsoli 72 4372 2012 10.1158/0008-5472.CAN-11-3536 Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice 

  112. Nature Kir 513 100 2014 10.1038/nature13528 Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia 

  113. Cell Rep Patsouris 13 1538 2015 10.1016/j.celrep.2015.10.028 Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans 

  114. Science (New York, NY) Lazar 307 373 2005 10.1126/science.1104342 How obesity causes diabetes: not a tall tale 

  115. Curr Opin Endocrinol Diabetes Obes Cypess 17 143 2010 10.1097/MED.0b013e328337a81f Brown fat as a therapy for obesity and diabetes 

  116. J Cardiovasc Risk Hokanson 3 213 1996 10.1097/00043798-199604000-00014 Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies 

  117. Nat Med Bartelt 17 200 2011 10.1038/nm.2297 Brown adipose tissue activity controls triglyceride clearance 

  118. J Biol Chem Liaset 286 28382 2011 10.1074/jbc.M111.234732 Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome 

  119. Nat Med Fang 21 159 2015 10.1038/nm.3760 Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance 

  120. Biosci Biotechnol Biochem Liu 70 86 2006 10.1271/bbb.70.86 Reducing Effect of Feeding Powdered Scallop Shell on the Body Fat Mass of Rats 

  121. Biosci Biotechnol Biochem Liu 70 2733 2006 10.1271/bbb.60349 Feeding Scallop Shell Powder Induces the Expression of Uncoupling Protein 1 (UCP1) in White Adipose Tissue of Rats 

  122. Nutr Metab (Lond) Azhar 13 89 2016 10.1186/s12986-016-0150-6 Phytochemicals as novel agents for the induction of browning in white adipose tissue 

  123. Biochem Biophys Res Commun Maeda 332 392 2005 10.1016/j.bbrc.2005.05.002 Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues 

  124. Vasc Pharmacol Leiherer 58 3 2013 10.1016/j.vph.2012.09.002 Phytochemicals and their impact on adipose tissue inflammation and diabetes 

  125. Curr Med Chem Orallo 13 87 2006 10.2174/092986706775197962 Comparative studies of the antioxidant effects of cis- and trans-resveratrol 

  126. Cell Metab Timmers 14 612 2011 10.1016/j.cmet.2011.10.002 Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans 

  127. Eur J Nutr Andrade 53 1503 2014 10.1007/s00394-014-0655-6 Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet 

  128. J Nutr Biochem Oi-Kano 18 685 2007 10.1016/j.jnutbio.2006.11.009 Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats 

  129. Am J Clin Nutr Rodriguez 75 213 2002 10.1093/ajcn/75.2.213 Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle 

  130. Eur J Nutr Cho 50 81 2011 10.1007/s00394-010-0117-8 Dietary naringenin increases hepatic peroxisome proliferators-activated receptor alpha protein expression and decreases plasma triglyceride and adiposity in rats 

  131. Cell Metab Xue 25 8311 2005 Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots 

  132. Environ Microbiol Leser 11 2194 2009 10.1111/j.1462-2920.2009.01941.x Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host 

  133. Science (New York, NY) Ridaura 341 1241214 2013 10.1126/science.1241214 Gut microbiota from twins discordant for obesity modulate metabolism in mice 

  134. Nat Rev Drug Discov Tseng 9 465 2010 10.1038/nrd3138 Cellular bioenergetics as a target for obesity therapy 

  135. PloS one Mossenbock 9 e110428 2014 10.1371/journal.pone.0110428 Browning of white adipose tissue uncouples glucose uptake from insulin signaling 

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